Xyrem (Sodium Oxybate) for Fibromyalgia

Sodium oxybate is the active ingredient in the narcolepsy drug Xyrem, which has been studied for fibromyalgia (FMS) and is sometimes used off-label for FMS and chronic fatigue syndrome (ME/CFS).

This drug carries a risk of addiction and abuse, so it's classified as a Schedule III controlled substance. That means it's only available to people meeting strict eligibility requirements, and healthcare providers are required to monitor its use very closely.

Sodium oxybate is a form of gamma-hydroxybutyrate (GHB), which is also known as the "date rape drug."

Happy woman in bed
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What It Does

Sodium oxybate is a central nervous system depressant that's thought to help you attain the deeper stage 3 and stage 4 levels of sleep. It's currently approved in the U.S. for reducing daytime sleepiness and cataplexy (sudden loss of muscle strength) in people with narcolepsy.

Deep sleep is believed to be impaired in FMS and ME/CFS, resulting in unrefreshing sleep.

For Fibromyalgia and Chronic Fatigue Syndrome

The FDA in 2010 rejected sodium oxybate as a treatment not because it doesn't work, but because the agency was concerned about the societal consequences of making a potentially dangerous drug available to millions of people.

Clinical trials on FMS have consistently shown that the drug can significantly improve sleep quality and reduce pain. A 2013 study (Spaeth) concluded that it had a good long-term safety profile as well.

A 2010 study (Spitzer) suggested it may be effective in ME/CFS as well, but this was the first study of this drug for ME/CFS.


Sodium oxybate is taken in liquid form, mixed with water. A typical starting dose for patients with narcolepsy is 4.5 grams a night, divided into 2 equal nightly doses. People frequently work up to 6-9 grams nightly, still in 2 equal doses.

Generally, patients are advised to prepare both doses and put them on the nightstand, then take the first one while sitting in bed. You might need an alarm clock to wake you up for the second one. This drug works quickly, so you should stay in bed once you've taken it.

Side Effects

Stop using sodium oxybate and get immediate medical help if you have symptoms of an allergic reaction, such as:

  • Difficulty breathing
  • Hives
  • Swelling of the face, lips, tongue or throat

Stop using sodium oxybate and call your healthcare provider right away if you have serious side effects, which include:

  • Hallucinations
  • Severe confusion
  • Shallow breathing
  • Sleepwalking
  • Waking up confused during the night

Other side effects may be less serious, including:

  • Agitation
  • Paranoia
  • Bowel or bladder control problems
  • Depression
  • Nausea or vomiting
  • Loss of appetite
  • Runny nose or nasal congestion and sore throat
  • Numbness or tingling
  • Tremors
  • Blurred vision

It's possible for you to have side effects not listed here. Be sure to discuss side effects with your healthcare provider.

Getting Sodium Oxybate

Healthcare providers can prescribe sodium oxybate off-label if they choose. However, because of the risks, it's not easy to get sodium oxybate.

For you to get it, your healthcare provider has to enroll you in a special program. The prescription then goes to the only pharmacy in the U.S. that's allowed to fill it, and the pharmacy ships the medication to you.

If you want to try sodium oxybate, talk to your healthcare provider. Keep in mind, though, that some healthcare providers may be uncomfortable prescribing it.

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