Librax Frequently Asked Questions

Benefits, Risks, Dosages, and Side Effects

Woman holding capsule

Tom Merton / OJO Images / Getty Images

Librax is a fixed-dose combination drug comprised of two different medications, chlordiazepoxide and clidinium. Chlordiazepoxide belongs to a class of drugs called benzodiazepines that are typically prescribed for anxiety and tension. Clidiniuman is an anticholinergic that prevents spasms in the muscles of the gut and bladder while reducing the excess production of stomach acid.

Librax may be prescribed for irritable bowel syndrome (IBS), diverticulosis, peptic ulcers, or an inflammation of the digestive tract (enterocolitis).

Dosage

Librax is available in capsule, tablet, and liquid formulations. Each dose contains 5 milligrams (mg) of chlordiazepoxide and 2.5 mg of clidinium 2.5 mg The daily dosage can vary by the condition being treated

Librax Dosing Recommendations
Conditon Recommended Dosage
Adult IBS 1 or 2 capsules 3 or 4 times daily before meals and at bedtime
Adult Enterocolitis 1 or 2 capsules 3 or 4 times daily before meals and at bedtime
Geriatric IBS 1 capsule twice daily with doses increased gradually as needed and tolerated
Geriatric Enterocolitis 1 capsule twice daily with doses increased gradually as needed and tolerated

For best results, Librax should be taken 30 minutes to one hour before eating a meal and right before bedtime. If you miss a dose, take it as soon as you remember. If the next dose is soon, just take that dose and forget the missed one. Don't double up doses in an effort to "catch up."

Possible Side Effects

Librax is known to cause considerable side effects, although some people are affected more than others. Common side effects include drowsiness, dizziness, constipation, nausea, blurred vision, and dry mouth. Many of these resolve over time as your body adjusts to the medication.

Librax may impotence in some men and menstrual irregularities in some women. Librax may also increase or decrease the sex drive (libido). Let your doctor know if such symptoms develop, especially if they are intolerable or you are planning a family.

Serious side effects of Librax can occur in some people, including mental changes (such as confusion or hallucinations) and difficulty in urination. Call your doctor immediately if you experience any such symptoms.

Librax can be psychologically and physically habit-forming. Let your doctor know if you have a history of alcohol or drug abuse. Under the supervision of a physician, Librax can be used safely over the long term as long as the recommended dose is never exceeded.

Librax should not be stopped suddenly but gradually tapered off under the supervision of a doctor. Stopping too quickly can cause withdrawal symptoms, including vomiting, confusion, anxiety, tremors, and spasms.

Interactions

Librax is known to interact with numerous medications, either increasing or decreasing the concentration of a drug in the blood stream. This can either lead to a worsening of side effects or reduce the efficacy of a drug. Key interactions include:

  • Antacids
  • Anti-arrhythmia drugs like Pronestyl (procainamide)
  • Anticoagulants like Coumadin (warfarin)
  • Antidepressants
  • Antihistamines
  • Lanoxin (digoxin)
  • Nizoral (ketoconazole)
  • Monoamine oxidase (MAO) inhibitors
  • Prednisone
  • Reglan (metoclopramide)
  • Sedatives like Ambien (zolpidem) and Halcion (triazolam)
  • Tagamet (cimetidine)
  • Thiazide diuretics like Dyazide (triamterene)

Some interactions can be mitigated by separating the doses by one to four hours. Others may require a dose reduction or drug substitution. Speak with your doctor to understand which drugs are problematic and how to avoid interactions.

Librax should be not be taken alcohol as their combined use can increase the sedative effect. This includes alcohol found in over-the-counter cough suppressants or cold remedies like Nyquil.

Contraindications

Librax is contraindicated for use in people with certain diseases and medical conditions. This means that the drug should not be used under any circumstance. These include:

  • Asthma or chronic lung disease
  • Any psychiatric illness, including depression
  • Enlarged prostate
  • Heart disease
  • Hiatal hernia
  • High blood pressure
  • Intestinal blockage
  • Irregular heartbeat
  • Kidney disease
  • Liver disease
  • Myasthenia gravis
  • Narrow-angle glaucoma
  • Thyroid disease
  • Toxic megacolon
  • Ulcerative colitis
  • Urinary retention or bladder neck obstruction

The U.S. Food and Drug Administration (FDA) has classified Librax as a Category D drug, meaning that studies have shown potential harm to the fetus. Librax should only be used during pregnancy if the benefits outweigh the risks.

Women in their child-bearing years should use contraception if prescribed Librax. The risk of fetal harm is greatest during the first trimester when fetal cells are still specializing.

It is unknown if the metabolites of Librax can be passed through breastmilk. With that said, Librax can suppress the production of breast milk in nursing mothers.

Was this page helpful?