Treating Chronic Constipation With Linzess

Known generically as linaclotide, this is effective for IBS-C and CIC

Constipation can be easy to joke about, but of course not being able to comfortably pass a bowel movement is no laughing matter. And while there are lots of potential causes of constipation (eating too little fiber, taking certain medications, lack of fluids), in most cases the condition is temporary and is easy to deal with by changing the diet, getting more exercise, or taking over-the-counter laxatives or stool softeners.

But for some folks, constipation can be a bigger problem—one that requires more aggressive treatment. That's where the prescription medication Linzess (linaclotide) comes in. (In Europe, linaclotide is sold under the brand name Costella.) It's used to treat people with a subtype of irritable bowel syndrome (IBS) who have constipation along with stomach pain, cramps, and bloating. It's often referred to as constipation-predominant irritable bowel syndrome (IBS-C).

Linzess also is used to treat chronic idiopathic constipation (CIC), which the National Institutes of Health defines as "difficult or infrequent passage of stools that lasts for three months or longer and is not caused by a disease or medication." If you're dealing with either IBS-C or CIC and your healthcare provider prescribes Linzess for you, here's what you need to know about how the drug helps relieve constipation and more.

Woman in bathrobe taking medication in bathroom
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How Linzess Works

Linzess is characterized as a "peptide agonist of guanylate cyclase-C receptors." This means the medication stimulates specific receptor cells within the digestive tract to increase the flow of fluid into the intestines.

This action is thought to speed up the rate at which the colon contracts and to reduce the amount of pain a person feels within the abdomen and digestive tract, what's known as "visceral hypersensitivity." Because Linzess is believed to work "locally," within the small and large intestine, there's a little risk that it will cause unwanted side effects, such as mild to moderate diarrhea.

The Effectiveness

Research shows Linzess works really well. For example, in clinical studies, compared to people taking a placebo, those taking Linzess were more likely to experience:

  • An increase in the number of bowel movements
  • Improved stool consistency
  • Less straining
  • Less abdominal pain and discomfort
  • Decrease in bloating

What's more, the drug works quickly once a person starts taking and is effective for as long as she's on it.

How to Take Linzess

Linzess comes as a capsule. It's easy to take: Swallow the capsule whole (don't crush it up, for example, because this will affect the rate at which your body absorbs it) and, unless your healthcare provider tells you otherwise, take it at the same time every day, on an empty stomach, no less than a half-hour before your first meal of the day. So for instance, if you normally have breakfast around 8 a.m., take your Linzess capsule before 7:30. 

One more precaution: Even though Linzess is a safe and effective medication for most people, it may not be a good idea for women who are pregnant or nursing a baby to take it. Make sure your healthcare provider knows if you're expecting or breastfeeding if he says he wants to prescribe Linzess for you. Otherwise, know that once you start taking the drug, you may start feeling better within a week or so.

5 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  2. Yu SW, Rao SS. Advances in the management of constipation-predominant irritable bowel syndrome: the role of linaclotide. Therap Adv Gastroenterol. 2014;7(5):193-205. doi:10.1177/1756283X14537882

  3. U.S. National Library for Medicine, MedlinePlus. Linaclotide.

  4. Corsetti M, Tack J. Linaclotide: A new drug for the treatment of chronic constipation and irritable bowel syndrome with constipation. United European Gastroenterol J. 2013;1(1):7-20. doi:10.1177/2050640612474446

  5. Lee N, Wald A. Linaclotide: evidence for its potential use in irritable bowel syndrome and chronic constipation. Core Evid. 2012;7:39-47. doi:10.2147/CE.S25240

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