List of Approved HIV Antiretroviral Drugs

More than 40 drugs are now available to treat HIV infection

Antiretroviral drugs are organized into five classes based on the stage of the HIV life cycle they inhibit. As of 2019, there are at least 28 individual agents (called drug molecules) and at least 13 fixed dosed combination (FDC) drugs comprised of two or more molecules. At least eight of the FDCs, in fact, can be used as a single-pill, once-daily therapy, ensuring greater treatment adherence and ease of use.

Antiretroviral therapy is typically prescribed using three different drug molecules, a strategy that was popularly known as HAART (highly active antiretroviral therapy). Since its introduction in 1996, HAART has evolved significantly and today offers fewer side effects and greater treatment efficacy than ever before.

In fact, the standard triple-drug therapy may soon be a thing of the past with two-drug therapies such as Juluca (dolutegravir + rilpivirine) now approved for use as a complete, all-in-one HIV therapy.

On August 30, 2018, the newest HIV drugs, Pifeltro (doravirine) and FDC antiretroviral Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate), were approved for use in newly treated patients by the U.S. Food and Drug Administration.

Drug Class Brand Name Generic Name Typical Adult Dosing Dietary Notes
Entry Inhibitors Fuzeon enfuvirtide, T-20 90mg (1 mL) injected twice daily None
  Selzentry, Celsentri maraviroc One 150mg tablet twice daily, one 300mg tablet twice daily, or two 300mg tablets twice daily, depending on drug regimen None
Pharmacokinetic Enhancers (a.k.a. HIV Boosters) Norvir ritonavir Technically a protease inhibitor, Norvir is used almost exclusively to "boost" the serum drug levels of other protease inhibitors (PIs); prescribers should consult with full prescribing information when co-administered with PIs Taken with or without food
  Tybost cobicistat 150mg taken once daily; technically a CYP3A inhibitor, Tybost is used to "boost" the serum drug levels of a number of protease inhibitors (PIs) Taken with food
Integrase Inhibitors Isentress raltegravir One 400mg tablet taken twice daily Taken with or without food
  Tivicay dolutegravir One 50mg tablet daily for untreated patients; one 50mg tablet twice daily for treatment-experienced patients with resistance to Isentress Taken with or without food
  Vitekta elvitegravir 85mg or 150mg tablet taken either once or twice daily, along with Norvir and another protease inhibitor; refer to
dosing chart for specific dosages
Taken with food
Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTIs/NtRTIs) Emtriva emtricitabine One 100mg tablet taken once daily, or one 150mg tablet taken twice daily Taken with or without food
  Epivir lamivudine One 300mg tablet taken once daily, or one 150mg tablet taken twice daily Taken with or without food
  Retrovir AZT, zidovudine One 300mg tablet taken twice daily Food may ease stomach discomfort
  Videx EC didanosine, ddI One 400mg capsule taken once daily; or one 200mg capsule taken once daily for patients under 133 lbs (60kg) Taken on empty stomach
  Viread tenofovir One 300mg tablet taken once daily Taken with or without food
  Zerit stavudine One 40mg capsule taken 12 hourly for patients 133 lb (60kg) and over; or one 30mg capsule taken 12 hourly for patients less than 133 lbs (60kg) Taken with or without food
  Ziagen abacavir Two 300mg tablets taken once daily, or one 300mg tablet taken twice daily Taken with or without food
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Edurant rilpivirine One 25mg tablet taken once daily Taken with a meal
  Intelence etravirine One 200mg tablet taken twice daily Taken with a meal
  Rescriptor delavirdine Two 200mg tablets taken three times daily Taken with or without food
  Pifeltro doravirine One 100mg tablet taken once daily Taken with or without food
  Sustiva efavirenz One 600mg tablet taken once daily Recommend empty stomach
  Viramune XR nevirapine Induction dose of one 200mg Viramune tablet daily for 14 days, then one 100mg Viramune XR tablet daily Taken with or without food
Protease Inhibitors (PIs) Aptivus tipranavir Two 250mg capsules taken with 200mg Norvir twice daily Best taken with a meal
  Crixivan indinavir Two 400mg capsules taken with either 100mg or 200mg Norvir twice daily (preferred), or two 400mg capsules taken every 8 hours With Norvir, take with or without food; without Norvir, take on empty stomach
  Invirase saquinavir Two 500mg tablets taken with 100mg Norvir twice daily Best taken with food or within 2 hours of eating
  Kaletra 200 mg lopinavir + 50mg Norvir (Note - lopinavir is only available as part of Kaletra) Two tablets twice daily; four tablets once daily is acceptable for untreated patients or patients with less than 3 mutations associated with lopinavir resistance Taken with or without food
  Lexiva, Telzir fosamprenavir Two 700mg tablets taken twice daily; or two 700mg tablets taken with 100mg 100mg Norvir once daily; or one 700mg tablet taken with 100mg Norvir twice daily for patients with previous PI failure Taken with or without food
  Prezista darunavir One 800mg tablet (or two 400mg tablets) taken with 100mg Norvir once daily; or one 600mg tablet taken with 100mg Norvir twice daily for patients with known levels of Prezista- associated resistance Taken with food
  Reyataz atazanavir Two 200mg capsules taken once daily, or one 300mg (or two 150mg) capsules taken with 100mg Norvir once daily Taken with light meal
  Viracept nelfinavir Two 625mg tablets taken twice daily, or five 250mg tablets taken twice daily, or three 250mg tablets taken three times daily Taken with a meal or light snack
Fixed Dose Combination (FDC) Drugs Combivir 300mg Retrovir + 150mg Epivir One tablet taken twice daily Food may ease stomach discomfort
  Epzicom 600mg Ziagen + 300mg Epivir One tablet taken once daily Taken with or without food
  Evotaz 300mg Reyataz + 150mg Tybost One tablet taken once daily Taken with food
  Prezcobix 800mg Prezista + 150mg Tybost One tablet taken once daily Taken with food
  Truvada 300mg Viread + 200mg Emtriva One tablet taken once daily Taken with or without food
All-in-One Fixed Dose Combination (FDC) Drugs Atripla 600mg Sustiva + 300mg Viread + 200mg Emtriva One tablet taken once daily; no other antiretroviral agent needed Best on empty stomach
  Biktarvy 50mg bictegravir + 200mg Viread + 25mg tenofovir alafenamide One tablet taken once daily; no other antiretroviral agent needed Taken with or without food
  Complera 25mg Edurant + 300mg Viread + 200mg Emtriva One tablet taken once daily; no other antiretroviral agent needed Best taken with food
  Delstrigo 100mg Pifeltro + 300mmg Epivir + 300 mg Viread One tablet taken once daily Taken with or without food
  Genvoya 150mg Vitekta + 150mg Tybost+ 10mg tenofovir alafenamide + 200mg Emtriva One tablet taken once daily; no other antiretroviral agent needed Taken with food
  Juluca 50mg Tivicay + 25mg Edurant One tablet taken once daily Taken with food
  Odefsey 25mg Edurant + 25mg tenofovir alafenamide + 200mg Emtriva One tablet taken once daily; no other antiretroviral agent needed Taken with food
  Stribild 150mg Vitekta + 150mg Tybost+ 300mg Viread + 200mg Emtriva One tablet taken once daily; no other antiretroviral agent needed Taken with food
  Triumeq 600mg Ziagen + 300mg Epivir + 50mg Tivicay One tablet once daily; no other antiretroviral agent needed Taken with or without food
  Trizivir 300mg Ziagen + 300mg Retrovir + 150mg Epivir One tablet taken twice daily; can be prescribed alone or in combination with other antiretroviral agents Best taken with food
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  1. U.S. Department of Health and Human Services. FDA-Approved HIV medications. Updated June 24, 2019.

  2. Arts EJ, Hazuda DJ. HIV-1 antiretroviral drug therapy. Cold Spring Harb Perspect Med. 2012;2(4):a007161. doi:10.1101/cshperspect.a007161

  3. U.S. Food and Drug Administration. FDA approves first two-drug regimen for certain patients with HIV. Updated November 21, 2017.

  4. U.S. Food and Drug Administration. Center for Drug Evaluation and Research approval package for Pifeltro and Delstrigo. Updated August 30, 2018.