List of Approved HIV Antiretroviral Drugs

More than 40 drugs are now available to treat HIV infection

Man hand taking medicine
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Antiretroviral drugs are organized into five classes based on the stage of the HIV life cycle they inhibit.

As of 2019, there are at least:

  • 28 individual agents (called drug molecules)
  • 13 fixed dosed combination (FDC) drugs made of two or more molecules

At least eight of the FDCs can be used as a single-pill, once-daily therapy, which makes it easier for people to take their medication consistently.

Antiretroviral therapy is typically prescribed using three different drug molecules, a strategy popularly known as HAART (highly active antiretroviral therapy). Since its introduction in 1996, HAART has evolved significantly and is now more effective and with fewer side effects.

In fact, the standard triple-drug therapy may soon be a thing of the past with two-drug therapies such as Juluca (dolutegravir + rilpivirine) now approved for use as a complete, all-in-one HIV therapy.

On August 30, 2018, the newest HIV drugs, Pifeltro (doravirine) and FDC antiretroviral Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate), were approved by the U.S. Food and Drug Administration for use in newly treated people.

DRUG CLASS: Entry Inhibitors
Brand Name  Generic Name Typical Adult Dosing Dietary Notes
Fuzeon  enfuvirtide, T-20  90mg injected 2x/day None
Selzentry, Celsentri  maraviroc -One 150mg tablet 2x/day
-One 300mg tablet 2x/day
-Two 300mg tablets 2x/day
None

Pharmacokinetic Enhancers

Also called HIV boosters, these drugs are typically used to "boost" the serum drug levels of other protease inhibitors (PIs).

DRUG CLASS: Pharmacokinetic Enhancers
 Brand Name Generic Name Typical Adult Dosing Dietary Notes
 Norvir ritonavir Dosage varies depending on what PIs it's taken with
(Technically a protease inhibitor)
Taken with or without food
 Tybost cobicistat 150mg 1x/day
(Technically a CYP3A inhibitor)
Taken with food
DRUG CLASS: Integrase Inhibitors
Brand Name  Generic Name Typical Adult Dosing Dietary Notes
Isentress raltegravir One 400mg tablet 2x/day Taken with or without food
Tivicay dolutegravir -Untreated patients:
One 50mg tablet 1x/day
-Patients with resistance to Isentress:
One 50mg tablet 2x/day
Taken with or without food
Vitekta elvitegravir -85mg or 150mg tablet 1x/day or 2x/day
-Taken with Norvir + another PI
Taken with food
DRUG CLASS: Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTIs/NtRTIs)
Brand Name  Generic Name Typical Adult Dosing Dietary Notes 
Emtriva emtricitabine -One 100mg tablet 1x/day
-One 150mg tablet 2x/day
Taken with or without food
Epivir lamivudine -One 300mg tablet 1x/day
-One 150mg tablet 2x/day
Taken with or without food
Retrovir AZT, zidovudine One 300mg tablet 2x/day Food may ease stomach discomfort
Videx EC didanosine, ddI -133 lb and over:
One 400mg capsule 1x/day
-Under 133 lbs:
One 200mg capsule 1x/day for
Taken on empty stomach
Viread tenofovir One 300mg tablet 1x/day Taken with or without food
Zerit stavudine -133 lb and over:
One 40mg capsule every 12 hours
-Under 133 lbs:
One 30mg capsule every 12 hours
Taken with or without food
Ziagen abacavir -Two 300mg tablets 1x/day
-One 300mg tablet 2x/day
Taken with or without food
DRUG CLASS: Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
 Brand Name Generic Name Typical Adult Dosage Dietary Notes
Edurant rilpivirine One 25mg tablet 1x/day Taken with a meal
Intelence etravirine One 200mg tablet 2x/day Taken with a meal
Rescriptor delavirdine Two 200mg tablets 3x/day Taken with or without food
Pifeltro doravirine One 100mg tablet 1x/day  Taken with or without food
Sustiva efavirenz One 600mg tablet 1x/day Recommend empty stomach
Viramune XR nevirapine -First 14 days:
One 200mg non-XR tablet 1x/day
-Maintenance dose:
One 100mg XR tablet 1x/day
Taken with or without food
DRUG CLASS: Protease Inhibitor
Brand Name  Generic Name Typical Adult Dosage Dietary Notes
Aptivus tipranavir Two 250mg capsules + 200mg Norvir 2x/day Best taken with a meal
Crixivan indinavir -Two 400mg capsules + 100mg or 200mg Norvir 2x/day
-Two 400mg capsules every 8 hours
-With Norvir: take with or without food
-Without Norvir take on empty stomach
Invirase saquinavir Two 500mg tablets + 200mg Norvir 2x/day Best taken with food or within 2 hours of eating
Kaletra 200mg lopinavir + 50mg Norvir -Two tablets 2x/day
-Untreated patients/Patients with < 3 mutations associated with lopinavir resistance:
Four tablets 1x/day
Taken with or without food
Lexiva, Telzir fosamprenavir -Two 700mg tablets 2x/day
-Two 700mg tablets + 100mg Norvir 1x/day
-Patients with previous PI failure:
One 700mg tablet + 100mg Norvir 2x/day
Taken with or without food
Prezista darunavir -800mg + 100mg Norvir 1x/day
-Patients with known levels of Prezista-associated resistance:
One 600mg tablet + 100mg Norvir 2x/day
Taken with food
Reyataz atazanavir -Two 200mg capsules 1x/day
-300mg + 100mg Norvir 1x/day
Taken with light meal
Viracept nelfinavir -Two 625mg tablets 2x/day
-Five 250mg tablets 2x/day
-Three 250mg tablets 3x/day
Take with a meal or light snack
DRUG CLASS: Fixed Dose Combination (FDC) Drugs
Brand Name Contents Typical Adult Dosage Dietary Notes
Combivir 300mg Retrovir
+ 150mg Epivir
One tablet 2x/day Food may ease stomach discomfort
Epzicom 600mg Ziagen
+ 300mg Epivir
One tablet 1x/day Taken with or without food
Evotaz 300mg Reyataz
+ 150mg Tybost
One tablet 1x/day Taken with food
Prezcobix 800mg Prezista
+ 150mg Tybost
One tablet 1x/day Taken with food
Truvada 300mg Viread
+ 200mg Emtriva
One tablet 1x/day Taken with or without food

All-in-One FDC Drugs

As the name suggests, these drugs don't need to be taken with another antiretroviral agent.

DRUG CLASS: All-in-One Fixed Dose Combination (FDC) Drugs
 Brand Name Contents Typical Adult Dosage Dietary Notes
Atripla 600mg Sustiva
+ 300mg Viread
+ 200mg Emtriva
One tablet 1x/day Best on empty stomach
Biktarvy 50mg bictegravir
+ 200mg Viread
+ 25mg tenofovir alafenamide
One tablet 1x/day Taken with or without food
Complera 25mg Edurant
+ 300mg Viread
+ 200mg Emtriva
One tablet 1x/day Best taken with food
Delstrigo 100mg Pifeltro
+ 300mmg Epivir
+ 300 mg Viread
One tablet 1x/day Taken with or without food
Genvoya 150mg Vitekta
+ 150mg Tybost
+ 10mg tenofovir alafenamide
+ 200mg Emtriva
One tablet 1x/day Taken with food
Juluca 50mg Tivicay
+ 25mg Edurant
One tablet 1x/day Taken with food
Odefsey 25mg Edurant
+ 25mg tenofovir alafenamide
+ 200mg Emtriva
One tablet 1x/day Taken with food
Stribild 150mg Vitekta
+ 150mg Tybost
+ 300mg Viread
+ 200mg Emtriva
One tablet 1x/day Taken with food
Triumeq 600mg Ziagen
+ 300mg Epivir
+ 50mg Tivicay
One tablet 1x/day Taken with or without food
Trizivir 300mg Ziagen
+ 300mg Retrovir
+ 150mg Epivir
-One tablet 2x/day
-Prescribed alone or + other antiretroviral agents
Best taken with food
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Article Sources
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  1. U.S. Department of Health and Human Services. FDA-Approved HIV medications. Updated June 24, 2019.

  2. Arts EJ, Hazuda DJ. HIV-1 antiretroviral drug therapy. Cold Spring Harb Perspect Med. 2012;2(4):a007161. doi:10.1101/cshperspect.a007161

  3. U.S. Food and Drug Administration. FDA approves first two-drug regimen for certain patients with HIV. Updated November 21, 2017.

  4. U.S. Food and Drug Administration. Center for Drug Evaluation and Research approval package for Pifeltro and Delstrigo. Updated August 30, 2018.