Understanding Lung Cancer Recurrence

Treatment and Prognosis When Lung Cancer Comes Back

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Lung cancer recurrence—even with tumors classified as early stage—is far too common, despite treatments that are currently available. A cancer recurrence is defined as cancer that returns (relapses) after treatment and following a period of time (remission) in which there is no evidence of cancer. On the other hand, cancers that are found within three months of the original diagnosis are usually considered a cancer progression.


A recurrence can be further defined by where it occurs:

  • Local – This is when cancer comes back in the lung, near the original tumor.
  • Regional – When cancer recurs in lymph nodes near the original tumor.
  • Distant – When lung cancer recurs in sites such as the bones, brain, adrenal glands or liver.

The chance that lung cancer will recur depends on many factors, including the type of lung cancer, the stage of lung cancer at which it is diagnosed, and the treatments for the original cancer.

Most lung cancers that recur do so in the first five years following diagnosis. That said, the risk of recurrence never returns to zero. One study that followed 5-year lung cancer survivors found that 87 percent made it another five years cancer-free.


Treatments for lung cancer, such as surgery and radiation therapy, are considered local treatments—that is, they treat cancer that is present near the site of the original tumor. Sometimes cells from the original tumor spread via the bloodstream or lymphatic channels to distant sites, but the cells are too small to be detected by radiological studies. Chemotherapy is designed to treat cancer cells that may have spread in this fashion. Sadly, even with chemotherapy, cells may survive and begin to grow at a later date.


Symptoms of a lung cancer recurrence will depend upon where cancer recurs. If it is a local recurrence, or in lymph nodes near the original tumor, symptoms may include a cough, coughing up blood, shortness of breath, wheezing, or pneumonia. Tumors that recur in the brain may cause dizziness, decreased or double vision, weakness on one side of the body, or loss of coordination. Tumors in the liver may result in abdominal pain, jaundice (a yellowish discoloration of the skin), itching or confusion. Recurrences in the bones most commonly present with deep pain in the chest, back, shoulders, or extremities. More generalized symptoms, such as fatigue and unintentional weight loss, may also signal a recurrence.


Treating a lung cancer recurrence will depend on the site where the cancer recurs. Once lung cancer recurs, there is little chance of the tumor being cured. That said, treatments are available that may both increase survival and improve quality of life. Possible treatments may include:

Surgery - Surgery is not commonly used to treat a lung cancer recurrence but may be used in some cases to treat a local recurrence or to treat isolated tumors in the brain or liver.

Radiation Therapy - The use of radiation therapy may be limited if previous radiation therapy has been given. A simplistic way to think about this is that there is a lifetime dose of radiation therapy that can be delivered to a certain area. Yet even if you have had prior radiation therapy, this is sometimes used to treat a recurrence by using a lesser dose.

Chemotherapy - Chemotherapy is usually the mainstay of treatment for lung cancer recurrence. That said, the chemotherapy that is chosen is usually different than the chemotherapy initially used to treat the tumor. Genetic mutations often occur in tumors that recur, making them resistant to chemotherapy drugs that were used previously.

Targeted Therapies - Targeted therapies are often helpful for people with advanced lung cancer who have an EGFR mutationALK-positive lung cancer or ROS1 positive lung cancer.

Immunotherapy - In 2015, 2 new immunotherapy medications were approved for the treatment of lung cancer. Though these medications do not work for everyone, for some people these treatments have resulted in long-term control of lung cancer which has recurred.

Metastasectomy - When only a few areas of lung cancer spread are present in the brain or the liver—something referred to as "oligometastases" — these areas may be removed via a procedure known as stereotactic body radiotherapy or SBRT. This procedure involves using a high dose of radiation to a small region (that where the metastasis is present) and has resulted in long-term control of metastatic lung cancer for some people.

Clinical Trials – Once a lung cancer recurs, it is usually by definition stage 4. According to the National Cancer Institute, people with stage 4 lung cancer should consider clinical trials as a treatment for their cancer. Learn more about clinical trials.


The prognosis of recurrent lung cancer will depend on many factors, including the site of recurrence, the type of lung cancer, your general health, and the treatments that are chosen to treat the recurrence. Even though a recurrence certainly lowers the expected life expectancy with lung cancer, some people live with good quality of life for many years following a recurrence.


Coping with a cancer recurrence is difficult, as all of the emotions that came with the original diagnosis of cancer resurface. Ask questions. Talk about options. Pull together your support network of loved ones and friends.

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