Can Lupus Cause Hives?

Lupus and hives sometimes go together, but only in about 10% of lupus cases. Lupus is a chronic autoimmune disease with a long list of symptoms that affect the skin. 

Hives (urticaria) are a rash that can be intensely itchy. The type involved in lupus typically lasts for more than 24 hours.

This article looks at the causes of lupus hives, how to identify and treat them, and what other lupus symptoms affect the skin.

A person with lupus sits on the floor in front of a bed

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Lupus and Hives

Lupus is an umbrella term for several related diseases. Frequent hives (chronic urticaria) are generally associated with the most common type, systemic lupus erythematosus (SLE).

SLE involves a misfiring immune system that attacks healthy parts of your body. Also, the inflammatory process is out of control, so it just keeps creating inflammation.

Hives are typically associated with allergies or infectious illnesses. That’s because they’re caused by a chemical in your body called histamine. Your immune system releases histamine when it senses a threat, such as dangerous bacteria, a bug bite, or something you’re allergic to.

The connections between lupus and hives aren’t fully understood. However, they’re both known to involve the immune system and inflammation. 

Some research suggests that chronic urticaria may be associated with increased likelihood of developing SLE. A newer line of research is looking into whether they’re both autoallergies (allergies to the self).

What Do Hives Look Like?

Hives can appear as bumps, raised patches of skin, or both. Each hive can vary from the size of a pinhead to a few inches across, and you can have just one or clusters of them.

On light skin, hives generally appear pink or red. On the darker skin of Black or brown people, they may be the same color as your skin, slightly lighter, or slightly darker. A characteristic that distinguishes hives from some other rashes is that it blanches (turns white when you press on the skin).

Chronic urticaria involves episodes of hives that last for at least six weeks. These episodes sometimes last for months or even years.

Breathing Problems? Call 911

When the swelling that accompanies hives affects the mouth or throat, it can lead to problems breathing. Always treat this as a medical emergency and get immediate treatment.

Lupus Hives Treatment

Some standard SLE treatments may help with hives, but they may not be the best treatments for chronic urticaria. 

H1 Blockers

The first-line treatment is an antihistamine (allergy medication) called H1 blockers. They interfere with how your body uses histamine. You may be prescribed up to four times the usual dose to manage your hives if necessary. (Don’t increase the dosage unless your healthcare provider recommends it.) Some H1 blockers are:

Additional Medication

For about half of people with lupus-related hives, these drugs alone aren’t enough to bring relief. Your healthcare provider may suggest other medications such as: 

Risk Factor or Early Symptom?

Hives may be the earliest sign of juvenile SLE. One study suggests that children who get hives have an increased risk of lupus.

Other Lupus Skin Problems

Lupus symptoms include several skin-related issues, varying from person to person. SLE skin symptoms include:

  • Malar rash (butterfly-shaped rash across the nose and cheeks)
  • Photosensitivity (exposure to sunlight and some artificial lighting can lead to rashes)
  • Livedo reticularis (lacy-patterned, blue, violet, or dark discoloration just under the skin)
  • Alopecia (hair loss)
  • Oral and nasal sores: (canker-sore-like ulcers)
  • Raynaud’s syndrome: (cold temperatures cause tightening in the fingers and toes)
  • Purpura (purple or red discoloration under the skin from leaking blood vessels)
  • Cutaneous vasculitis (discolored patches that resemble hives but they don’t blanch)

If you have any skin problems, talk to your healthcare provider about how to treat and manage them.

When to See a Healthcare Provider

Any time you develop hives without a known reason, you should seek medical care. They could signify a serious allergic reaction or an undiagnosed underlying illness.

If you’re not diagnosed with lupus but have skin symptoms or other problems that may be linked to the disease, make an appointment with your healthcare provider. They may run tests or refer you to a specialist for diagnosis and treatment.

If you are diagnosed with lupus, let your healthcare provider know about:

  • New symptoms
  • Worsening symptoms (flares)
  • Possible drug side effects

Also, let them know if a new medication doesn’t appear to be working.


Lupus can cause hives, likely because of the two conditions’ common autoimmune and inflammatory aspects. Hives are raised, discolored areas of the skin. Some lupus treatments, such as Plaquenil and steroids, may help eliminate hives. However, antihistamines are typically the preferred treatment for hives. Always see a healthcare provider for hives, especially if you don’t know the cause.

A Word From Verywell

Hives can be severe and disruptive to your life. Adding them on top of your other lupus symptoms can be a lot to deal with. However, remember that hives can be treated. See your healthcare provider so they can rule out more urgent causes and get you on the path to treatment.

Frequently Asked Questions

  • Why does lupus cause hives in some people?

    It’s not fully understood why lupus sometimes causes hives. It’s believed to be due to the common underlying mechanisms: autoimmunity and inflammation. Some research suggests autoallergy (allergy to parts of yourself) may also be involved.

  • How long do hives last?

    Outside of an autoimmune disease, individual hives may last a few minutes, a few hours, or about a day. New hives may develop and fade over a few days or weeks in a prolonged episode. Individual hives from lupus tend to last for more than 24 hours, and episodes can stretch for months.

  • What are autoimmune hives?

    Autoimmune hives are caused by the immune system attacking healthy skin cells, which leads to inflammation and other symptoms. Experts don’t yet know why autoimmune disorders develop.

13 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Johns Hopkins Lupus Center. Lupus-specific skin disease and skin problems.

  2. Johns Hopkins Lupus Center. How lupus affects the immune system.

  3. American Academy of Dermatology Association. Hives: causes.

  4. Yong SB, Su KW, Chen HH, Huang JY, Wu HJ, Wei JC. Impact of chronic urticaria on systemic lupus erythematosus: a nationwide population-based study in Taiwan. J Dermatol. 2019;46(1):26-32. doi:10.1111/1346-8138.14683

  5. Maurer M, Altrichter S, Schmetzer O, Scheffel J, Church MK, Metz M. Immunoglobulin e-mediated autoimmunity. Front Immunol. 2018;9:689. doi:10.3389/fimmu.2018.00689

  6. Fraser K, Robertson L. Chronic urticaria and autoimmunity. Skin Therapy Lett. 2013;18(7):5-9.

  7. American Academy of Dermatology Association. Hives: overview.

  8. American Academy of Dermatology Association. Hives: signs and symptoms.

  9. Souza Botelho M, Bolfi F, Leite RGOF, et al. Systematic review and meta-analysis of the safety of chloroquine and hydroxychloroquine from randomized controlled trials on malarial and non-malarial conditions. Syst Rev. 2021;10(1):294. doi:10.1186/s13643-021-01835-x

  10. Lin CH, Hung PH, Hu HY, Chung CJ, Chen TH, Hung KY. Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: a nationwide population-based case-control study. Pediatr Allergy Immunol. 2018;29(7):732-739. doi:10.1111/pai.12962

  11. Sajjan VV, Lunge S, Swamy MB, Pandit AM. Livedo reticularis: a review of the literature. Indian Dermatol Online J. 2015;6(5):315-321. doi:10.4103/2229-5178.164493

  12. Kallas R, Goldman D, Petri MA. Cutaneous vasculitis in SLE. Lupus Sci Med. 2020;7(1):e000411. doi:10.1136/lupus-2020-000411

  13. American Osteopathic College of Dermatology. Urticaria.

By Adrienne Dellwo
Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic.