10 Things You Should Know About Lyrica (Pregabalin)

Safe Use to Decrease Unwanted Side Effects

Lyrica (pregabalin) is an FDA-approved drug that is used to treat fibromyalgia and certain other conditions. You may have seen advertisements for Lyrica and want to know more about its benefits and precautions. It is always important to follow directions to decrease the risk of undesirable side effects. Here are 10 things you should know about Lyrica.

Red and white capsules, such as Lyrica.
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Lyrica Reduces Pain and Improves Function

Lyrica is not a cure for fibromyalgia, but it may help control your symptoms. It can take several weeks before you feel the benefits.

Exactly how Lyrica works is unknown. Fibromyalgia symptoms have been linked to changes in the brain which influence how people perceive pain. Fibromyalgia patients experience a heightened sensitivity to stimuli that are not normally painful to others. Some data suggests Lyrica binds to a protein in nerve cells that is responsible for the heightened sensitivity.

Lyrica Was the First FDA-Approved Medicine for Fibromyalgia

Lyrica was approved for the treatment of fibromyalgia in adults 18 years and older in 2007. The drug, marketed by Pfizer, was previously approved for the management of diabetic peripheral neuropathy, post-herpetic neuralgia, and as an additional therapy for adults with partial onset seizures. Until the approval of Lyrica capsules, no medicine was specifically approved to treat fibromyalgia. Symptoms of fibromyalgia had been treated with:

  • Pain medications
  • NSAIDs
  • Sleep medications
  • Muscle relaxers
  • Antidepressants

Since the approval of Lyrica, the FDA has also approved Cymbalta (duloxetine hydrochloride) and Savella (milnacipran HCI) for treatment of fibromyalgia. Those medications act as antidepressants while Lyrica does not.

It Is Important to Discuss Potential Benefits vs. Risks With Your Doctor

People who are prescribed Lyrica must fully understand dosage, directions, side effects, and potentially serious adverse events associated with the drug. While it may be a very beneficial drug for some people with fibromyalgia, precautions for safe use must be followed.

Lyrica May Cause Common Side Effects

According to Pfizer, common side effects reported in patients taking Lyrica include:

  • Dizziness
  • Blurred vision
  • Weight gain
  • Sleepiness/drowsiness
  • Difficulty with concentration/attention
  • Swelling of hands and feet
  • Dry mouth
  • Edema
  • Constipation
  • Increased appetite

Because of the possibility of dizziness or drowsiness, the drug may impair your ability to drive or operate complex machinery.

Lyrica May Cause Rare but Potentially Serious Side Effects

Some people have reported allergic reactions to Lyrica, including swelling of the face, mouth, lips, gums, tongue, and neck. Others experienced trouble breathing, rash, hives, and blisters. If any of these symptoms occur, you should stop taking Lyrica immediately and seek medical care.

A small number of people, about 1 in 500, may have suicidal thoughts or actions with Lyrica, as is common for antiepileptic drugs.

Don't stop taking the medication, but contact your doctor if you have such thoughts or if you have anxiety, depression, irritability, agitation, or other unusual behavior that is new or worsening.

Swelling of the hands and feet are another serious symptom, especially if you have heart problems. Consult your doctor immediately.

Lyrica May Interact With Other Medications

If prescribed Lyrica, you must inform your doctor about all medications that you take, prescription and non-prescription, as well as any supplements. Especially important to note are ACE inhibitors, narcotics, and Avandia (rosiglitazone) or Actos (pioglitazone) for diabetes.

People Who Have Prior Drug or Alcohol Problems May Be More Likely to Misuse Lyrica

As with any prior significant medical problem, people who have abused or been addicted to drugs or alcohol in the past should inform their doctor. Because of the increased possibility of misuse of Lyrica in those individuals, closer monitoring may be necessary or another treatment may be preferable.

People Taking Lyrica Should Not Stop the Drug Without Consulting Their Doctor

Lyrica should be taken at the prescribed dosage. If a dose of Lyrica is missed and it's almost time for the next dose, skip the missed dose. Two doses of Lyrica should not be taken together. Patients should continue taking the drug even after experiencing pain relief. Also, plan for refills so that the prescription does not run out.

Special Considerations Are Needed for Pregnancy

As it stands, women who are pregnant or plan to become pregnant should notify their doctor before starting the drug. No adequate, well-controlled studies have been conducted in pregnant humans, and use is only appropriate when the potential benefit to the mother outweighs possible risk to the fetus.

Men who are planning for fatherhood should also talk with their doctor before taking Lyrica. Studies showed that the drug made male animals less fertile. Also, birth defects occurred in the offspring of male animals who were treated with pregabalin.

Lyrica for Sciatica Has Controversial Research Findings

Study results published in 2017 concluded that patients with sciatica improved to the same level whether given Lyrica (pregabalin) or placebo. While the drug has been prescribed for various nerve-related conditions, including sciatica, some researchers do not recommend its use for sciatica based on the results. But, not all researchers agree—some think it may be useful for chronic sciatica. For certain, if you are currently taking Lyrica (pregabalin), do not stop without consulting your doctor first.

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  1. U.S. Food & Drug Administration. Approval Package for Lyrica. Approved December 30, 2004.

  2. Wolfe F, Ross K, Anderson J, Russell IJ. Aspects of fibromyalgia in the general population: sex, pain threshold, and fibromyalgia symptoms. J Rheumatol. 1995;22(1):151-6.

  3. U.S. Food & Drug Administration. Lyrica [labeling]. Revised May 2018.

  4. U.S. Food & Drug Administration. Living with Fibromyalgia, Drugs Approved to Manage Pain. Revised January 31, 2014

  5. Winterfeld U, Merlob P, Baud D, et al. Pregnancy outcome following maternal exposure to pregabalin may call for concern. Neurology. 2016;86(24):2251-7. doi:10.1212/WNL.0000000000002767

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