The Health Benefits of Magnesium Malate

This supplement may help with fatigue and muscle performance

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Magnesium has numerous health benefits. It's an anti-inflammatory, fights depression, and may increase your ability to exercise. Elemental magnesium is not easily taken up by the body, though, and is much easier to absorb in the form of a salt, bound to some other substance.

Magnesium malate, a combination of magnesium and malic acid (which is found in apples), is one such salt formulation. This particular formulation of magnesium may be helpful for conditions related to over-excitation of the neuromuscular system, including chronic fatigue syndrome and fibromyalgia. Both magnesium and malic acid are frequently recommended for these conditions, although early research suggesting a benefit has not been replicated.

Magnesium is important for the formation of cells, and the maintenance of muscles, bones, and nerves. While many people obtain their daily recommended amounts of magnesium through diet, a 2016 review found that the magnesium content of foods has been reduced in many countries with industrial agriculture. As such, people who experience a deficiency may have a hard time correcting it through diet alone.

You may have heard of malic acid being used solo as well. It is often taken by people looking to improve muscle performance, reduce fatigue after exercise, and improve mental focus.

Health Benefits

Magnesium, in various formations, regulates a lot of important functions and systems in your body, including:

  • Nerves, including neuroexcitability
  • Muscles
  • Blood sugar levels
  • Blood pressure
  • Production of protein, bone, and DNA

Many of these things are believed to be dysregulated in fibromyalgia and chronic fatigue syndrome.

While not many studies have been undertaken using the magnesium malate formulation specifically, evidence across different formulations of magnesium for several uses is promising.

Still, salt formulations made from various combinations of magnesium with other chemicals differ in their rates of intestinal absorption. Available formulations other than magnesium malate include:

  • Magnesium sulfate
  • Magnesium oxalate
  • Magnesium citrate

Animal studies suggest that magnesium malate may have better bioavailability than other formations. If sufficient magnesium is present, the effects of one salt combination may be able to be applied to another. However, the lower-end threshold dose of one formulation cannot be interchanged with another. This is important to keep in mind when interpreting this research.

Neuromuscular Excitability

Several conditions related to neuromuscular excitability may be helped by magnesium's effect on hypertension and neuronal excitation. These include:

  • Bruxism: According to a review, several case studies demonstrate the promise of oral magnesium for alleviating bruxism (jaw clenching or teeth gnashing), a condition common to people who use stimulant medication.
  • Restless legs syndrome (RLS): In addition, a study of 100 patients with type 2 diabetes found that oral magnesium supplementation improved symptoms of RLS, a condition characterized by an irresistible urge to move the legs.
  • Postpartum seizures: According to a 2011 review, of 1,687 women experiencing seizures after pregnancy, women who received an intravenous magnesium salt had a 52 percent lower risk of subsequent convulsions than those given diazepam.

Deficiency of magnesium during pregnancy can lead to preeclampsia and impede fetal development. An expecting mother's need for magnesium can increase to as high as 400 milligrams (mg) in order to be able to properly repair body tissues. Supplements are one way to meet this increased need and will not harm the fetus.

Fibromyalgia and Chronic Fatigue Syndrome

A 2010 review of treatments for fibromyalgia and chronic fatigue syndrome stated that magnesium malate is among the supplements with the most potential for future research for managing the symptoms of these conditions, which are characterized by low energy, among other symptoms.

Both magnesium and malic acid help produce energy for your cells in the form of adenosine triphosphate (ATP), which numerous studies have found to be deficient in patients with fibromyalgia and chronic fatigue syndrome.

A 2016 study published in the journal Pain Management suggests that low levels of magnesium and zinc in fibromyalgia patients may encourage a process called excitotoxicity, in which the neurotransmitter glutamate gets carried away and overstimulates those cells to death.

A 2015 feasibility study suggests supplementation of magnesium malate may boost energy and alleviate pain and tenderness in fibromyalgia patients.

However, a 2019 review of the literature concluded that the use of magnesium and malic acid made little or no difference in fibromyalgia pain or depression.

Possible Side Effects

Excess magnesium will be eliminated by the kidneys through urine. However, people who take high doses of magnesium malate may experience intestinal problems, such as persistent diarrhea, bloating, or cramping.

A 2011 review notes that the more magnesium you take, the smaller the percentage that is rapidly absorbed by the body. This can lead to the retention of fluid within the colon that can cause these side effects.


A 2016 review of forty prospective cohort studies with over 1 million participants found no significant relationship between increasing dietary magnesium by 100 mg per day and risk of total cardiovascular disease. However, according to another review, magnesium is commonly administered after cardiac surgery to prevent arrhythmias and may interact with other heart medications.


A 2018 review in Advanced Chronic Kidney Disease describes several clinical trials in which magnesium was shown to lower blood pressure. People who are at risk for hypotension should limit their magnesium intake, and those who take blood pressure medications should talk to their doctors before taking magnesium supplements.

Dosage and Preparation

Magnesium malate supplements are most often taken orally with a meal.

According to the National Institutes of Health (NIH), the recommended daily allowance (RDA) of magnesium, for the population in general, varies by age and gender.

RDA for Magnesium
Age Women Men
19 to 30 years 310 mg 400 mg
31 and older 320 mg 420 mg

Daily dosages of malic acid generally range from 1,200 mg to 2,800 mg.

People under stress, pregnant and breastfeeding women, people with diabetes, athletes, and growing adolescents may have higher magnesium requirements and should talk to their doctors to determine an optimal dose.

What to Look For

Make sure you read the label as you assess which brand of magnesium malate is right for you. There will be a Supplement Facts label listing the active ingredients per serving as well as any added ingredients such as fillers, binders, and flavorings.

There also may be a seal of approval from a third party quality testing organization such as ConsumerLab, U.S. Pharmacopeia, and NSF International. These seals of approval do not guarantee safety, efficacy, or evaluation by the U.S. Food and Drug Administration (FDA), but they do establish that the product contains the ingredients listed on the label, does not contain a harmful amount of contaminants, and was manufactured properly.

Foods high in magnesium tend to be dark green leafy vegetables, nuts, legumes, and unrefined grains. Regardless of your magnesium needs, all are important parts of a healthy diet.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

By Adrienne Dellwo
Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic.