Digestive Health Inflammatory Bowel Disease Living With Medications That Can Harm the Esophagus By Amber J. Tresca facebook twitter linkedin Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. She was diagnosed with ulcerative colitis at age 16. Learn about our editorial process Amber J. Tresca Medically reviewed by Medically reviewed by John Carew, MD on November 25, 2019 twitter linkedin John Carew, MD, is board-certified in otolaryngology-head and neck surgery. He is an adjunct assistant professor at Mount Sinai Medical Center and NYU Medical Center. Learn about our Medical Review Board John Carew, MD Updated on November 26, 2019 Print The esophagus is an important part of the digestive tract — we use our throat every time we eat or drink. Several diseases and conditions can affect the esophagus and some medications can also cause certain problems. For people who already have a digestive disease or condition such as inflammatory bowel disease (IBD), taking proper care of the esophagus and preventing injury is going to be very important to an improved prognosis. Here are some of the ways that medications can affect the esophagus. Patrick Heagney / Getty Images Irritation in the Esophagus Some conditions can cause difficulty in swallowing pills, or in the pills not traveling down the esophagus in the manner in which they should. If a pill stays in the esophagus, it may dissolve or start its mechanism of action there, instead of further down the digestive tract where it is supposed to go. This includes conditions such as strictures (narrow points) in the esophagus, scleroderma, achalasia, and in some people who have had a stroke. In some cases, if the medication is not going smoothly down the esophagus, it can cause irritation or even more serious problems such as bleeding, or an ulcer or a perforation. There is also the possibility, under certain conditions, that the esophagus can narrow in parts, causing a stricture. The medications and supplements that are most often associated with causing ulcers when they become stuck in the throat are antibiotics, aspirin, iron, potassium chloride, quinidine (Quinidine Gluconate, Quinidine Sulfate), and vitamin C. Symptoms of irritation in the esophagus as a result of a medication or esophagus include: Dull shoulder or chest pain after taking a pill Feeling that medication is stuck or not moving down the throat Pain in the throat after swallowing If you are having problems swallowing medications, you should talk to your doctor. There are also some steps you can take to help yourself swallow pills: Drink a sip or two of water beforehand Drink an entire glass of water after taking medication Stand or sit upright when swallowing Wait 30 minutes or longer before lying down Gastroesophageal Reflux Disease (GERD) Between the esophagus and the stomach, there is a flap that keeps food from backing up from the stomach into the esophagus. When that flap isn't working properly, it could cause the contents of the stomach—which are very acidic—to back up into the esophagus. This can lead to heartburn or indigestion. Some medications can affect the esophageal flap and lead to the development of gastroesophageal reflux disease (GERD). Medicines that can cause symptoms of esophageal reflux include nitrates (for treating chest pain and angina), theophylline (used to treat respiratory disease), calcium channel blockers (used for treating high blood pressure, migraines and Raynaud's disease), anticholinergics (used to treat asthma, incontinence, gastrointestinal pain, muscle spasms, depression, and sleep disorders), and birth control pills. Some of the signs and symptoms of GERD can include: Heartburn or indigestion Feeling as if food is coming back up into the throat If you are having symptoms of GERD, you should speak to your doctor. There are also some tips you can use to lessen the symptoms of heartburn: Avoid coffee, alcohol, chocolate, fried food, and fatty foods Stop smoking Wait 30 minutes or longer before lying down Esophageal Diseases and Conditions If you have a disease or condition that affects the esophagus, talk to your doctor about the medications and supplements you take and how you take them. In some cases, it might be necessary to change or discontinue medications that can cause further harm to the esophagus. Was this page helpful? Thanks for your feedback! We're providing tips on how to take better care of your gut. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. González-fernández M, Ottenstein L, Atanelov L, Christian AB. Dysphagia after Stroke: an Overview. Curr Phys Med Rehabil Rep. 2013;1(3):187-196. doi:10.1007/s40141-013-0017-y Philpott HL, Nandurkar S, Lubel J, Gibson PR. Drug-induced gastrointestinal disorders. Frontline Gastroenterol. 2014;5(1):49-57. doi:10.1136/flgastro-2013-100316 Zhang Y, Tong Y, Wang W, Xu L. Chest pain from pill-induced esophagitis: A rare side effect of ascorbic acid. SAGE Open Med Case Rep. 2018;6:2050313X18775004. doi:10.1177/2050313X18775004 Additional Reading Dağ MS, Öztürk ZA, Akın I, Tutar E, et al. "Drug-induced esophageal ulcers: case series and the review of the literature." Turk J Gastroenterol. 2014 Apr;25(2):180-4. doi: 10.5152/tjg.2014.5415. Geagea A, Cellier C. "Scope of drug-induced, infectious and allergic esophageal injury." Curr Opin Gastroenterol. 2008 Jul;24(4):496-501. doi: 10.1097/MOG.0b013e328304de94.