Arthritis Treatment Pain Relief Rayos (Prednisone) and Medrol (Methylprednisolone) How to choose between arthritis medications By Kelly Burch Kelly Burch Facebook LinkedIn Twitter Kelly Burch is a freelance journalist who has covered health topics for more than 10 years. Her writing has appeared in The Washington Post, The Chicago Tribune, and more. Learn about our editorial process Updated on April 12, 2021 Medically reviewed by Violetta Shamilova, PharmD Medically reviewed by Violetta Shamilova, PharmD Violetta Shamilova, PharmD, is a board-licensed pharmacist. She is an assistant professor at the Touro College School of Health Sciences, and has worked at CVS pharmacy for five years. She completed the certified APhA Delivering Medication Therapy Management Services course. Learn about our Medical Expert Board Print Table of Contents View All Table of Contents Similarities Differences Safety Warnings In the United States, 23% of all adults, or more than 54 million people, have arthritis—a disease that causes inflammation in the joints. Many of them turn to medications to help relieve pain and inflammation and improve their quality of life. Corticosteroids—often referred to as “steroids”—can reduce inflammation and therefore the pain and stiffness associated with arthritis. Rayos (prednisone) and Medrol (methylprednisolone) are two types of steroids that are commonly prescribed to treat arthritis pain and inflammation. They can also both be used to treat allergies and asthma. Rayos and Medrol are tablets that must be taken according to the specific instructions and timing outlined by your healthcare provider. Morsa Images / Getty Images How Prednisone and Methylprednisolone Are Similar Prednisone and methylprednisolone are both corticosteroids. This class of medication is used to treat arthritis and other conditions including allergies and asthma. Corticosteroids are meant to mimic the actions of cortisol, a steroid that is naturally produced by the body in response to stress. When they are used in people with arthritis, corticosteroids: Reduce inflammationSuppress the immune system This is helpful because arthritis is thought to be caused in part by an over-activation of the immune system. Corticosteroids can be taken by: MouthInjectedApplied to the skin Rayos and Medrol are both tablets that are taken by mouth at least once per day. It’s important to follow those instructions exactly. In most cases, your healthcare provider will tell you to taper your dose, gradually reducing it until you are no longer on the medications. How Prednisone and Methylprednisolone Are Different Prednisone and methylprednisolone act on the body in very similar ways. The biggest difference between the medications are in regards to dosage and how they are administered. Rayos is a delayed-release prednisone tablet that is available in 1, 2, or 5 milligram doses.Medrol is a tablet of methylprednisolone available as 2, 4, 8, 16 or 32-milligram doses. Methylprednisolone is a stronger medication than prednisone, so in general, smaller doses are used. When you’re considering whether to take Rayos or Medrol, it’s important to consider that Rayos is a delayed-release tablet. For many people, that means that Rayos can be taken once-daily, while Medrol may require more than one dose per day. Rayos is formulated to take effect during the night. That’s when cells called cytokines, which can contribute to inflammation, become most active. Because of this approach, some people experience a better reduction of inflammation taking Rayos than they do while taking Medrol. Others may prefer Rayos because they only need to take one pill a day, rather than multiple. Is It Safe to Take Prednisone and Methylprednisolone? Prednisone and methylprednisolone were both approved for use by the Food and Drug Administration (FDA) in the 1950s, and have been used since. They are both considered safe drugs, especially when they’re used in the short term. However, there are risks involved with taking corticosteroids, including Rayos and Medrol, especially when they’re used for a long period of time. Talk to your healthcare provider about the benefits and risks of using either medication long-term to manage your arthritis. Combining Steroid Medications In most cases, a person should only take one type of steroid medication, so it’s unlikely that you would take prednisone and methylprednisolone at the same time. Always talk with your healthcare provider about all medications that you’re taking, including over-the-counter (OTC) medicines and supplements. Even these substances can interact with corticosteroids. In most cases, a person should only take one type of steroid medication, so it’s unlikely that you would take prednisone and methylprednisolone at the same time. Always talk with your healthcare provider about all medications that you’re taking, including over-the-counter (OTC) medicines and supplements. Even these substances can interact with corticosteroids. People who are taking prednisone and methylprednisolone for arthritis should talk to their healthcare provider about the interactions between these corticosteroids and nonsteroidal anti-inflammatory pain medications, known as NSAIDs. NSAIDs include prescription medications like: IndocinIbuprofen If you’re taking both corticosteroids and NSAIDs, you could increase your risk for gastrointestinal bleeding, a side effect of NSAIDs. Corticosteroid Warnings Rayos and Medrol share many of the same side effects. In the short-term, side effects include: Stomach upsetIrritability or mood swingsFacial hair growth, especially for womenHigh blood pressureIncreased risk for infection Occasionally, people on prednisone and methylprednisolone can experience serious side effects. You should contact your healthcare provider immediately if you experience any of the following: Skin rashesSwellingVision changesVomiting, nausea or tarry stools, which can indicate internal bleeding If you use corticosteroids for a long-time, they can affect your body’s natural production of steroids. Because of that, you’ll have to taper off the synthetic steroids slowly to avoid complications. A Word From Verywell Dealing with the pain from arthritis can be very challenging. If you have arthritis, you’ll need to work with your healthcare provider to develop a pain-management regimen that provides you relief, without exposing you to long-term side effects. Rayos and Medrol provide similar relief for arthritis symptoms since both mimic the naturally-occurring steroid cortisol. Your healthcare provider can help you determine whether one or the other might provide better relief in your specific case. If you’re considering a steroid medication like Rayos and Medrol, be sure to talk to your practitioner about side effects and work on a plan to only use the medications for a short period of time. 7 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Centers for Disease Control and Prevention. Arthritis. MedlinePlus. Prednisone. University of Washington Medicine: Orthopedic and Sports Medicine. Corticosteroids for arthritis. University of Washington Medicine: Orthopedic and Sports Medicine. Corticosteroids for arthritis. DailyMed. Rayos. MedlinePlus. Methylprednisolone. Food and Drug Administration. Highlights of prescribing information: Rayos. By Kelly Burch Kelly Burch is has written about health topics for more than a decade. Her writing has appeared in The Washington Post, The Chicago Tribune, and more. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit