Migraine Prevention (Prophylaxis)

Prescription Treatments to Keep Migraines Away

Taking medicine
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Migraine headaches can hit at any time, and treating them may not always be convenient, so it may be helpful to learn more about migraine prevention. If you suffer from regular migraines, your health care provider may recommend preventative treatments rather than simple abortive therapies. Four FDA-approved prescription medications are used for migraine prevention, but other options that may work as well.

FDA-Approved Medications

The Food and Drug Administration has approved four medications for migraine prevention, or prophylaxis. They are propranolol (Inderal), timolol (Blocadren), topiramate (Topamax) and divalproex sodium (Depakote). These are considered the “first-line” treatments in migraine prophylaxis. There are times when you may not be able to tolerate them because of side effects or because one of the first-line treatments is ineffective. When this occurs, your healthcare provider may prescribe another medication that may be helpful. This is typically called using a medication “off-label.” This is quite common and may be the best solution for you.


Beta-blockers are medications usually used in treating high blood pressure (hypertension), but there are a number of other uses for them as well. Propranolol and timolol are both beta-blockers. Others that may be tried in migraine treatments include atenolol (Tenormin), long-acting metoprolol (Toprol XL) or nadolol (Corgard). Common side effects include fatigue, nausea, dizziness, insomnia, and depression. Contraindications to their use include hypoglycemia associated with diabetes, hypotension, asthma or some heart conditions.


Amitriptyline is an antidepressant known as a tricyclic antidepressant (TCA). While not FDA-approved for migraine prevention, there have been multiple studies showing that amitriptyline can be an effective prophylactic medication. It seems to be especially effective when you have migraines that take on various forms or have features common in tension headaches. Amitriptyline may also be effective when migraine sufferers have insomnia or depression that accompanies the headaches. Common side effects include drowsiness, weight gain, and dry mouth.

The Selective Serotonin Reuptake Inhibitors (SSRIs), such as fluoxetine (Prozac), are occasionally used in migraine prevention, but research does not support their widespread use.


Anticonvulsants are medications originally intended to treat epileptic seizures. They have other uses as well, including preventing migraine headaches. Divalproex (Depakote) is FDA-approved, and numerous studies support its use. Gastrointestinal side effects are common but decrease as time passes. Pregnant patients and those with liver disease or a history of pancreatitis should not use it at all.

Topiramate (Topamax) is another anticonvulsant that seems to be a good choice for migraine prevention. Common side effects include fatigue and nausea, although lower dosages didn’t cause as many problems.

Other Choices

There are a number of other medications that are used to prevent migraines, none of which have been FDA-approved at this point. Lisinopril (Zestril), an ACE-inhibitor used for treating hypertension, has shown some promise in preventing migraines. Candesartan (Atacand) is an angiotensin receptor blocker (ARB) that, according to one study, may be effective in migraine prophylaxis.

Calcium channel blockers are blood pressure medications that have historically been used for migraine prevention. There is little to no scientific evidence to support their use, although there is some weak evidence suggesting verapamil (Calan) may be helpful.

Chronic nonsteroidal anti-inflammatory drug (NSAID) use can be dangerous because of the gastrointestinal problems they can cause, but there are some cases where NSAIDs may be useful in preventing migraines, especially naproxen (Naprosyn). Taking NSAIDs before and during early menstruation may be helpful in preventing menstrual migraines.

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Migraine. National Headache Foundation. Retrieved: December 9, 2008. http://www.headaches.org/education/Headache_Topic_Sheets/Migraine

Modi S, Lowder DM. Medications for migraine prophylaxis. Am Fam Physician. 2006 Nov 15;74(10):1685. Retrieved: December 9, 2008. http://www.aafp.org/afp/20060101/72.html

Tronvik E, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA, 2003;289:65-9.

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