Sleep Disorders Treatment Mirapex to Treat Restless Legs Syndrome By Brandon Peters, MD Brandon Peters, MD Facebook Twitter Brandon Peters, MD, is a board-certified neurologist and sleep medicine specialist. Learn about our editorial process Updated on January 05, 2020 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Cristian Zanartu, MD Medically reviewed by Cristian Zanartu, MD Twitter Cristian Zanartu, MD, is a licensed board-certified internist who has worked for over five years in pain and palliative medicine. Learn about our Medical Expert Board Print Table of Contents View All Table of Contents Uses Mechanism Contraindications Side Effects Safety Precautions The pharmaceutical drug pramipexole, sold under the brand names of Mirapex and Mirapex ER, is a commonly prescribed medication used to treat restless legs syndrome. Terry Vine / Blend Images / Getty Images Uses Mirapex is a medication that acts to stimulate dopamine receptors. It is used to treat conditions like restless legs syndrome and Parkinson’s disease. There are two types of Mirapex available on the market. One is the standard formulation and the other is an extended release (ER) version. It takes the body a longer time to metabolize Mirapex ER, which means it can be taken less frequently, but the effects of each formulation are the same. How It Works It is not known precisely how Mirapex works, but it is thought to act within the nervous system at the site of a neurotransmitter called dopamine. Neurotransmitters are chemicals that serve as messengers between nerve cells called neurons. Mirapex is believed to stimulate dopamine receptors, which increases their activity. Who Should Not Use It In some cases, it may be advised that you should not use Mirapex. In individuals with a history of heart disease or kidney problems, you may wish to discuss with your healthcare provider whether Mirapex is safe for you. Caution should be used if you take other medications that depress the central nervous system, so make certain your healthcare provider is aware of all the medications that you take. If you drink alcohol, have sleep disorders or are elderly, you should likewise be cautious when using Mirapex. Side Effects As with any drug, there are potential side effects with the use of Mirapex. You are unlikely to experience most of these, and may not have any of them, but some side effects that commonly occur with the use of Mirapex include: Low blood pressure with standing Abnormal movements Nausea Dizziness or lightheadedness Sleepiness or insomnia Constipation Loss of sensation Hallucinations Swelling Confusion Accidental injury Loss of appetite Amnesia (memory loss) Vision changes Headache Difficulty swallowing Malaise or feeling unwell Weight loss Impotence Dry mouth Stiffness Difficulties walking Increased urinary frequency Flu-like symptoms Nasal congestion Pain in the extremities With the use of any drug, including Mirapex, there are also risks of serious side effects. These occur more rarely, but include: Sudden sleep episodes Fainting spells (syncope) Abnormal movements Compulsive behaviors Hallucinations Malignant melanoma (skin cancer) Rhabdomyolysis (muscle breakdown) Fibrosis (tissue scarring) Rebound phenomena or augmentation (change of symptoms) Safety Precautions As described above, certain people should use Mirapex with caution or not at all. Your kidney function should be checked when you start Mirapex with a blood test to measure creatinine. Once started, the medication should not be stopped abruptly. It is important to have routine skin examinations and your blood pressure should be carefully monitored, especially when the dose is being adjusted. The safety of using Mirapex during pregnancy or breastfeeding is unknown. If you experience any difficulties, you should be in close contact with your primary healthcare provider. 1 Source Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Eisenreich W, Sommer B, Hartter S, Jost WH. Pramipexole extended release: a novel treatment option in Parkinson's disease. Parkinsons Dis. 2010;2010:612619. doi:10.4061/2010/612619 Additional Reading Antonini A, Calandrella D. Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson's disease: implications for patients. Neuropsychiatr Dis Treat. 2011;7:297-302. doi:10.2147/NDT.S10097 Editorial Process Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit