Symptoms of Monkeypox

Common symptoms include rash, fever, fatigue, and swollen lymph nodes

Monkeypox is a type of zoonotic viral disease (a virus that spreads from animals to humans). It was first identified in 1958 in monkeys being used for research. But monkeys aren't the only carriers of monkeypox—other animals, including rodents, can transmit the virus.

Humans can get monkeypox if an infected animal bites them or they come in contact with an infected animal's fur or bodily fluids. They can also get it from close contact with an infected person. 

The monkeypox virus is from the same family of viruses that causes smallpox. Many monkeypox symptoms are similar to smallpox but milder. Monkeypox is rarely fatal. The most common symptoms of monkeypox are fever and chills, headache, lethargy, muscle and joint pain, fatigue, swollen lymph nodes, and rash. 

This article will cover the most common symptoms of monkeypox, less common ones, complications, and when to see a healthcare provider. 

Monkeypox rash on hands

Mustafa Kaya / Getty Images

Frequent Symptoms 

While there are classic symptoms of monkeypox, it is possible to not experience all the signs.

Researchers found that in the 2022 outbreak, many cases did not follow the general symptom patterns. This new presentation pattern includes fewer skin symptoms and the appearance of the skin symptoms before lymph node swelling, fever, or other symptoms.

Symptoms will start within three weeks of exposure. It is possible to test positive for the monkeypox virus and not have any symptoms.

Fever and Chills 

Fever and chills are part of an invasion period lasting from zero to five days. A study reported in 2022 found 62% of study participants experienced fever as an initial symptom. With fever, the body will start to feel cold as the temperature climbs, and you will experience shivers and chills.


Intense headache is another common symptom experienced during the invasion period for monkeypox. It might affect around 27% of people who contract the virus.


Lethargy refers to a state of fatigue accompanied by a lack of physical and mental motivation. It affects around 41% of people who contract the monkeypox virus.

Muscle Aches and Joint Pain

People who experience a fever with monkeypox might also experience muscle aches and joint pain. Back pain and muscle pain are considered common symptoms that are part of the invasion period.


Fatigue is a common symptom of most viruses and illnesses, and monkeypox is no different. Fatigue with a viral disease causes a significant lack of energy and exhaustion that sleep and rest cannot immediately resolve.

Fatigue is expected as the body is fighting the monkeypox virus but will improve as you start to feel better and other symptoms dissipate.

Respiratory Symptoms

Some people experience upper respiratory symptoms with monkeypox. Respiratory symptoms might include sore throat, nasal congestion, or cough.

Swollen Lymph Nodes

Lymphadenopathy (swollen lymph nodes) is one of the most significant symptoms of monkeypox, affecting more than half the people who contract the virus. Lymph node swelling in monkeypox can occur in the neck, armpits, and groin on one or both sides of the body.

Skin Rash

After a few days of early symptoms, a rash will develop. This rash can vary in appearance, the number of lesions, and distribution.

It typically appears as flat, red bumps, developing over time into papules (raised bumps), vesicles (small fluid-filled blisters), and pustules (a bump containing pus) before drying up, scabbing over, and falling off. The rash can be painful and itchy.

Monkeypox sores can appear on the mouth, genitals, or anus. Some people might experience blisters on their hands and the soles of their feet.

Symptoms in Children 

Children seem to experience the same symptoms as adults. Infants, children under age 8, children with eczema and other skin conditions, and those with immunocompromising conditions may be at increased risk for sever disease when they contract monkeypox.

Most children will experience fatigue, headaches, difficulty swallowing, cough, and other classic symptoms. They can also have facial lesions near their eyes and eyelid crusting. 

How Long Will Symptoms Last?

The symptoms of monkeypox start within three weeks after exposure to the virus. If you develop flu-like symptoms, you will likely experience a rash within a few days. According to the Centers for Disease Control and Prevention (CDC), the entire course of the illness is from two to four weeks.

Rare Symptoms 

Monkeypox is recognizable by the type of rash it causes and the symptoms that occur before the rash appears. But some signs of the condition considered less common might affect smaller numbers of people. Rarer symptoms include eye and gastrointestinal symptoms. 

Eye Symptoms 

Some people who contract monkeypox will experience ophthalmological (eye-related) symptoms.

Monkeypox eye symptoms might include blepharitis (eyelid infection), conjunctivitis, focal conjunctival lesions (tumors of the conjunctiva, which is the mucous membrane covering the front of the eye and inside of the eyelids), corneal ulcerations (open sores on the cornea, which is the clear covering on the front of your eye), light sensitivity, keratitis (inflammation of the cornea), and vision loss.

According to a 2022 Nature report, ophthalmic manifestations are much rarer compared to other symptoms of monkeypox.

According to this report, eye symptoms linked to monkeypox include:

  • Conjunctivitis (pink eye) and edema (swelling): Both symptoms will affect the eyelids of 20% of people with monkeypox. People with conjunctivitis had a higher frequency of other symptoms, including "nausea, chills/sweating, oral ulcers, sore throat, general malaise, lymphadenopathy [lymph node disease], and photophobia [eye pain in bright light]." This study also found that 47% of people with conjunctivitis from monkeypox reported being bedridden, compared to 16% who did not have conjunctivitis.
  • Corneal involvement that ranged from mild to severe
  • Corneal infections that lead to keratitis
  • Corneal scarring 
  • Permanent vision loss: One study found that unilateral or bilateral blindness and weak vision occurred in 10% of primary monkeypox cases (infection from an animal source) and 5% of secondary cases (person-to-person transmission).
  • Blepharitis in 30% of unvaccinated cases

Gastrointestinal Symptoms

Gastrointestinal symptoms like nausea, vomiting, and diarrhea are not classic symptoms of monkeypox. But gastrointestinal symptoms can occur in some people with viral illnesses.

People who experience these symptoms might also have severe dehydration, which could, along with other severe symptoms of monkeypox, lead to electrolyte abnormalities (variation in the level of charged minerals in the blood, such as sodium and potassium) and shock (diminished blood flow to the organs and tissues).

Complications/Subgroup Indications 

Monkeypox can lead to severe complications, some of which might require hospitalization or more extensive treatment methods. Those at greater risk for severe disease include young children (under 8 years), individuals who are pregnant or immunocompromised, and individuals with history of atopic dermatitis or eczema.

Complications of monkeypox can include:

  • Secondary skin infections
  • Severe scarring on the face, arms, and legs
  • Pneumonia (lung inflammation)
  • Vision changes or blindness
  • Proctitis (inflammation and sores inside the rectum) and urinary problems
  • Death (rare)

An observational study reported in August 2022 in the journal Clinical Microbiology and Infection found that 36% of study participants had monkeypox complications. The most commonly observed complications were anal region pain and cellulitis (a skin infection).

Complications that required hospitalization included cellulitis, paronychia (nail infection), severe digestive and anal involvement, noncardiac angina (chest pain in people without heart disease), dysphagia (swallowing difficulty), blepharitis, and keratitis.

When to See a Healthcare Provider

People who have been in close contact with a person or animal with monkeypox should monitor their health for at least three weeks after exposure. You should check your body temperature daily.

If you develop a fever (100.4 or above), swollen lymph nodes, rash, or other monkeypox symptoms, self-isolate and contact a healthcare provider immediately. 

Monkeypox is rare in the United States. It is transmitted by close contact. If you develop a new rash, have symptoms of monkeypox, and think you have been exposed to the virus, you should reach out to a healthcare provider. 


Monkeypox is a zoonotic viral disease, meaning it is transmitted from animals to humans. It also can be transmitted between humans. The monkeypox virus is related to the virus that causes smallpox. It can cause similar but mild symptoms. 

The most common symptoms of monkeypox are fever, headache, lethargy, muscle and joint pain, fatigue, swollen lymph nodes, and rash. Less common symptoms include severe eye symptoms and gastrointestinal symptoms.

Monkeypox can cause more serious problems considered complications, including nail and skin infections, noncardiac chest pain, problems with swelling, and inflammatory eye troubles. 

If you have been in close contact with a person or animal with monkeypox, you should monitor yourself for at least three weeks. If you develop symptoms, self-isolate and call a healthcare provider. 

A Word From Verywell 

For most people who contract monkeypox, the condition is mild and self-limiting. But it can be a serious disease, especially for immunocompromised children and adults (people who have a weakened immune system).

Most people recover fully from monkeypox, but some might experience severe complications. Therefore, it is crucial to seek medical help if you think you might have been exposed, especially for a child or anyone with an underlying health condition.

Frequently Asked Questions

  • What is the biggest misconception about monkeypox?

    A big misconception about monkeypox is that only men who have sex with other men (MSM) are at risk for monkeypox. This is not true—this virus does not discriminate. It is important to avoid this line of thought and reach out to a healthcare provider if you think you might be experiencing symptoms of monkeypox.

  • If I have had the smallpox vaccine, am I protected against monkeypox?

    Because the virus linked to monkeypox is closely related to the smallpox virus, having had the smallpox vaccine might offer some protection. But smallpox was eradicated in the United States in the 1980s, and many people under age 50 have never received the vaccine.

    In addition, anyone who is vaccinated got their vaccine many decades ago, and it is unknown how long they would be protected. The CDC recommends that if you have not had smallpox vaccine in the past three years and are exposed to monkeypox, you should get revaccinated.

  • How does monkeypox spread?

    You can become exposed to the virus that causes monkeypox if you encounter an infected animal or person. Animal-to-person exposure can occur through a bite or scratch or exposure to the infected animal's blood, lesions, or body fluids.

    Exposure from person to person is less common but can occur with skin-to-skin contact. This includes intimate contact like hugging, kissing, massage, or sexual relations, contact with respiratory secretions, fabrics, and surfaces touched by someone with the virus, and direct contact with monkeypox rash, scabs, or body fluids from a person with the virus. 

15 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Centers for Disease Control and Prevention. About monkeypox

  2. World Health Organization. Multi-country monkeypox outbreak: situation update.

  3. Centers for Disease Control and Prevention. Signs and symptoms.

  4. De Baetselier I, Van Dijck C, Kenyon C, et al. Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in BelgiumNat Med. 2022;10.1038/s41591-022-02004-w. doi:10.1038/s41591-022-02004-w

  5. World Health Organization. Monkeypox.

  6. Thornhill JP, Barkati S, Walmsley S, et al. Monkeypox virus infection in humans across 16 countries - April-June 2022N Engl J Med. 2022;387(8):679-691. doi:10.1056/NEJMoa2207323

  7. Centers for Disease Control and Prevention. Clinician FAQs.

  8. Centers for Disease Control and Prevention. Clinical recognition.

  9. Centers for Disease Control and Prevention. Clinical considerations for monkeypox in children and adolescents.

  10. Abdelaal A, Serhan HA, Mahmoud MA, Rodriguez-Morales AJ, Sah R. Ophthalmic manifestations of monkeypox virus. Eye (Lond). 2022 Jul 27. doi:10.1038/s41433-022-02195-z

  11. Mailhe M, Beaumont AL, Thy M, et al. Clinical characteristics of ambulatory and hospitalised patients with monkeypox virus infection: an observational cohort study. Clinical Microbiology and Infection. 2022:S1198-743X(22)00428-1. doi:10.1016/j.cmi.2022.08.012

  12. World Health Organization. Monkeypox.

  13. Centers for Disease Control and Prevention. Monitoring and risk assessment for persons exposed in the community.

  14. Centers for Disease Control and Prevention. Monkeypox and smallpox vaccine guidance.

  15. Centers for Disease Control and Prevention. How it spreads.

Additional Reading

By Lana Barhum
Lana Barhum has been a freelance medical writer since 2009. She shares advice on living well with chronic disease.