Motegrity (Prucalopride) -Oral

What Is Motegrity?

Motegrity (prucalopride) is a medicine that treats chronic idiopathic constipation in adults.

As a prokinetic agent, prucalopride (the active ingredient in Motegrity) works on the serotonin receptors (5-HT4) in the body to stimulate the bowels' movement.

Motegrity is available via prescription as a round tablet in 1-milligram (mg) and 2-milligram doses.

Drug Facts

Generic Name: Prucalopride

Brand Name: Motegrity

Drug Availability: Prescription

Administration Route: Oral

Therapeutic Classification: Prokinetic

Available Generically: No

Controlled Substance: No

Active Ingredient: Prucalopride

Dosage Form: Tablet

What Is Motegrity Used For?

The Food and Drug Administration (FDA) approved prucalopride for treating chronic idiopathic constipation (CIC) in adults.

Prucalopride helps stimulate bowel movements to improve constipation symptoms. It is often not the first treatment choice for this condition, but it is usually prescribed after therapies like osmotic laxatives do not work.

How to Take Motegrity

Use this medicine exactly as directed by your healthcare provider. Follow all the directions on your medication label, and do not take more than prescribed. You can take Motegrity without regard to food.

Talk to your healthcare provider or pharmacist if you do not understand how to take your medications.

Storage

Store Motegrity tablets in the original container at a controlled room temperature of 59 F to 77 F. Keep away from moisture and heat. Keep out of the reach of children and pets. When traveling, transport prucalopride in your carry-on or your checked baggage with its original label.

Off-Label Uses

Healthcare providers may prescribe prucalopride for off-label uses, meaning for conditions not specifically indicated by the FDA.

Prucalopride may be used off-label to treat:

If you are prescribed Motegiry for an off-label condition, always follow your healthcare provider's guidance on how to take it. Misusing this medication without the advice of a healthcare provider can result in severe or life-threatening side effects.

How Long Does Motegrity Take to Work?

After oral administration, Motegrity enters the bloodstream within two to three hours and starts working. 

What Are the Side Effects of Motegrity?

This is not a complete list of side effects, and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your healthcare provider or pharmacist. You may report side effects to the FDA at fda.gov/medwatch or 1-800-FDA-1088.

Common Side Effects

Common side effects of Motegrity can include:

Severe Side Effects

Call your healthcare provider immediately if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency.

Motegrity can result in suicidal thoughts or actions and new or worsening depression. Stop taking it immediately and contact your healthcare provider if you notice suicidal ideation and behaviors or severe mood changes.

Report Side Effects

Motegrity may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your healthcare provider may send a report to theFDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Motegrity Should I Take?

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The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For chronic idiopathic constipation:
      • Adults—2 milligrams (mg) once a day.
      • Children—Use and dose must be determined by your doctor.

Modifications

Certain factors may affect how you take Motegrity. Before starting treatment, talk to your healthcare provider if any of the following apply to you.

Pregnancy

The risk of taking Motegrity during pregnancy is unknown. Your healthcare provider may enroll you in a registry that monitors outcomes in individuals exposed to Motegrity during pregnancy.


Lactation

Prucalopride is present in breast milk. The effects on a breastfed infant or milk production are unknown. Talk with your healthcare provider about feeding your baby while taking Motegrity. If you are breastfeeding while on prucalopride, it is recommended to watch for diarrhea in the breastfed infant.


Use in Older Adults

No overall differences in safety and effectiveness were observed between older (65 and up) and younger people. Older people may need an adjusted dose based on kidney function.


Renal Impairment 

Motegrity leaves the body through the kidneys. A lower dose is recommended in people with severe kidney impairment because the risk of adverse reactions may be greater in this population.


Liver Impairment

People with liver issues do not need to adjust their dosage.

Missed Dose

If you miss a dose of this medication, take it as soon as you remember. However, you can skip the missed dose if it is almost time for your next dose. Resume medication at your next scheduled time. Do not take extra to make up for the missed dose. Talk to your healthcare provider or pharmacist if you are unsure of what to do

Overdose: What Happens If I Take Too Much Motegrity?

Motegrity overdose can happen if you take too much of it. Overdose symptoms include headache, nausea, and diarrhea.

What Happens If I Take Too Much Motegrity?

If you think you or someone else may have overdosed on Motegrity, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Motegrity, call 911 immediately.

Precautions

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It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.

What Are the Reasons I Shouldn’t Take Motegrity?

Avoid taking Motegrity if you are allergic to it or if you have:

What Other Medications Interact With Motegrity?

There are no significant interactions known for Motegrity. Tell your healthcare provider about all your medications, including prescription and over-the-counter (OTC) medicines, vitamins, and herbal supplements.

What Medications Are Similar?

Medications similar to Motegrity include:

Zelnorm (tegaserod)

Tegaserod is approved only in adult women under 65 with constipation-dominant irritable bowel syndrome (IBS-C). It works similarly to Motegrity by binding serotonin type-4 (5-HT4) receptors to stimulate gut motility.

Tegaserod is taken twice daily, which can be more burdensome than Motegrity. Avoid tegaserod if you have ever had a heart attack, stroke, angina, intestinal ischemia, liver or kidney disease, and those with a history of bowel obstruction, active gallbladder disease, or suspected dysfunction with your sphincter of Oddi.


Linzess (linaclotide)

Linaclotide treats IBS-C and chronic idiopathic constipation in adults. It increases intestinal fluid secretion and movement by targeting guanylate cyclase-C (GC-C) receptors. Those with any intestinal blockage should not take this medication.


Amitiza (lubiprostone)

Lubiprostone is a prescription laxative medication in the class of drugs known as prostaglandins. It is approved to treat adults with long-term constipation and IBS-C in women.

Lubiprostone increases the amount of fluid in the bowels by boosting chloride production in the intestine. This helps soften the stool, allowing it to pass more easily. It is uncertain if this medication is safe during pregnancy or breastfeeding. Avoid Amitiza if you have a bowel obstruction or severe diarrhea.

Frequently Asked Questions

  • What Is Motegrity Used For?

    Motegrity is a prescription-only medicine used in adults to treat chronic idiopathic constipation. It is not known if this medication is safe and effective in children.

  • How should I store Motegrity?

    Store this medication at room temperature. Keep in the original container to protect from moisture. Keep Motegrity and all medicines out of the reach of children.

  • What are the side effects of Motegrity?

    Motegrity may cause severe side effects, including unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop right away and tell your healthcare provider immediately if:

    • Your depression gets worse
    • You begin to have thoughts of hurting yourself
    • You have tried to hurt yourself
    • You develop new depression

    The most common side effects include: 

    • Headache
    • Nausea or vomiting
    • Dizziness
    • Gas or bloating
    • Stomach pain
    • Diarrhea
    • Fatigue

    These are not all the possible side effects of Motegrity. Call your healthcare provider or pharmacist for medical advice about side effects.

How Can I Stay Healthy While Taking Motegrity?

Motegrity treats chronic idiopathic constipation in adults. Idiopathic means the cause of constipation is unknown. While this uncertainty can be frustrating, many people find relief with medications like Motegrity. Outside of medicine, it is vital to maintain a healthy gut by eating a high-fiber diet and exercising regularly. 


Stop using prucalopride and contact your healthcare provider at once if you experience:

  • Unusual changes in mood or behavior
  • Ongoing or worsening depression
  • Thoughts about suicide or hurting yourself or
  • Sad or hopeless feelings


Remember to take Motegrity once a day as directed by your healthcare provider. If you keep forgetting to take it, consider setting alarms or reminders. Ask your healthcare provider or pharmacist any questions about the medication.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

10 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  5. Sloots CE, Rykx A, Cools M, Kerstens R, De Pauw M. Efficacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation. Dig Dis Sci. 2010;55(10):2912-2921. doi:10.1007/s10620-010-1229-y

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  7. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Prucalopride.

  8. Food and Drug Administration. Zelnorm label.

  9. Food and Drug Administration. Linzess label.

  10. Food and Drug Administration. Amitiza label.