Multiple Sclerosis & Anxiety: What’s the Link?

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Many people with multiple sclerosis (MS) experience mental health symptoms, including anxiety. The uncertain nature of the condition—in which relapses and new symptoms seemingly can strike at any time—is thought to be a major reason why. But the immune system's attack on the brain and the resulting neuroinflammation and neurological changes also seem to play a role.

Read on to learn about how MS can lead to anxiety and how to cope.

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MS and Anxiety

It's common for people with MS to experience symptoms of anxiety or have anxiety disorders.

The exact prevalence of people with MS experiencing anxiety symptoms varies among studies, but it is believed to be between 34% and 43%. This is much higher than the estimated prevalence of about 18% in the U.S. population overall.

Despite the high occurrence, anxiety in people with MS remains understudied.

There is some evidence that anxiety may be related to neuroinflammation and deficits in frontal lobe functioning (including attention, problem-solving, and memory retrieval) that occur with MS. Research also suggests that it may be due to living with the unpredictability of MS rather than the physical disease process.

MS symptoms and progression can vary. Concern about the potential seriousness of symptoms and outcome of future episodes may contribute to severe and/or prolonged anxiety in people with MS. Research suggests that anxiety tends to be higher at the onset of the condition.

Increased anxiety in people with MS is also associated with:

Demyelination (damage to the protective covering surrounding nerve cells), damage to nerve fibers, and some of the medications used to treat MS (such as corticosteroids) may also contribute to emotional changes and anxiety in people with MS.

Left untreated, anxiety in people with MS can lead to:

  • Impaired social functioning and decreased social interaction
  • Impaired cognitive functioning
  • Lowered treatment compliance
  • Lower quality of life
  • Physical symptoms or worsening MS symptoms
  • Increased thoughts or actions of self-harm or suicide (particularly if depression is also present)

Help Is Available

If you or a loved one is having thoughts of suicide, call 911 or the National Suicide Prevention Lifeline at 988. For more mental health resources, see our National Helpline Database.

Symptoms of Anxiety

Anxiety can have both physiological and psychological symptoms.

Physiological symptoms may include:

  • Shortness of breath
  • Trembling
  • Increased heart rate or heart palpitations
  • Hot or cold sensations
  • Dry mouth
  • Fatigue
  • Nausea
  • Tense muscles
  • Restlessness
  • Sleep difficulties, especially trouble falling asleep
  • Frequent urination

Psychological symptoms include:

  • Frequently feeling worried, guilty, or out of control
  • Racing thoughts
  • Difficulty making decisions
  • Chronic feelings of unhappiness
  • Feeling inadequate, criticized, or easily embarrassed
  • Inflexibility and being less willing to make changes
  • Hostility or anger toward others
  • Repeating certain behaviors or thoughts
  • Over-anticipating things
  • Excessive concern with physical health
  • Thinking negatively about the future

Anxiety or MS Symptoms?

Anxiety symptoms can overlap with MS symptoms. Talk with your healthcare provider about all of your symptoms to get an overall picture of what you are experiencing.

Strategies for Coping With MS Anxiety

Anxiety with MS can be managed with professional treatment and coping strategies.


For some, medication may be beneficial. Options include:

  • Antidepressants: Including Celexa (citalopram), Lexapro (escitalopram), Effexor (venlafaxine), and Cymbalta (duloxetine hydrochloride)
  • Antianxiety medications (or benzodiazepines): Including Valium (diazepam), for short-term use


Working with a mental health professional can help a person with MS learn to manage their anxiety symptoms.

Some strategies include:

  • Cognitive behavioral therapy (CBT): Learning to identify problematic thoughts and behaviors and changing them into productive ones
  • Biofeedback: Learning to control body responses
  • Acceptance and commitment therapy (ACT): Identifying what is most valuable to the person and finding a way to pursue it
  • Support groups: Interacting with others who are also living with anxiety and MS


Practicing mindfulness techniques and exercises, whether led by a professional or on your own, may help with anxiety.

Examples include:

  • Guided imagery
  • Body scan exercise
  • Meditation
  • Mindfulness-based stress reduction (MBSR)

Other Measures

Physical exercise and being mobile to the best of your ability may help improve anxiety symptoms. Practicing yoga is a great way to combine physical activity with mindfulness.

Increased social support—including emotional, technical, and informational support—from people such as family members, friends, coworkers, healthcare professionals, and other people with MS has been shown to help mitigate the impact of anxiety and depression.

Don't Ignore Symptoms

Identifying anxiety early can make a big difference in treating and living with the condition. If you notice signs of anxiety, don't wait to talk to your healthcare provider.

How to Get Help

Finding the help that works best for you is important. You can start by talking to your healthcare provider. They can help you find resources and make a referral to a specialist or mental health professional if necessary.

The format with which you receive help is also important. In-person sessions are an option, but remote therapy is also a promising choice, especially if access is an issue.

When looking for a therapist or other professional to help with your anxiety, it can help to have some questions prepared ahead of time. For example:

  • What is your experience working with people who have MS and anxiety?
  • Which therapies and relaxation techniques do you use?
  • Are your services covered by my insurance?
  • Do you involve care partners and family members in the treatment?
  • What are your feelings on using medication for anxiety?

The National Multiple Sclerosis Society provides a search tool that can help you find different types of resources available to you.


It is common for people with MS to experience symptoms of anxiety or anxiety disorders. This may be due to neuroinflammation as a result of MS, or the psychological stress that comes with being diagnosed with a chronic condition. Left untreated, this anxiety can affect functioning and quality of life.

Treatments like medication, therapy, and mindfulness exercises can help with anxiety management. Physical activity, such as yoga, and increased social support can also provide benefits.

A Word From Verywell 

While looking after your physical health with MS, it's just as important to care for your mental health. If you are experiencing symptoms of anxiety, talk to your healthcare provider or a mental health professional about what you're feeling. Anxiety can be treated and managed alongside MS.

Frequently Asked Questions

  • Does anxiety make MS symptoms worse?

    If left untreated, anxiety can negatively affect many areas of your health, including MS symptoms.

  • How does MS cause anxiety?

    Neuroinflammation (an inflammatory response within the brain or spinal cord) plays a role in the presence of anxiety with MS. Anxiety can also be the result of being diagnosed with a life-changing condition like MS.

17 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Gay MC, Bungener C, Thomas S, et al. Anxiety, emotional processing and depression in people with multiple sclerosis. BMC Neurol. 2017;17(1):43. doi:10.1186/s12883-017-0803-8

  2. Rossi S, Studer V, Motta C, et al. Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis. Neurology. 2017;89(13):1338-1347. doi:10.1212/WNL.0000000000004411

  3. Multiple Sclerosis Association of America. Anxiety.

  4. Boeschoten RE, Braamse AMJ, Beekman ATF, Cuijpers P, van Oppen P, Dekker J, Uitdehaag. Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis. J Neurol Sci. 2017;372:331-341. doi:10.1016/j.jns.2016.11.067

  5. Anxiety and Depression Association of America. Did you know?.

  6. Pham T, Jetté N, Bulloch AGM, Burton JM, Wiebe S, Patten SB. The prevalence of anxiety and associated factors in persons with multiple sclerosis. Multiple Sclerosis and Related Disorders. 2018;19:35-39. doi:10.1016/j.msard.2017.11.003

  7. Guimarães J, Sá MJ. Cognitive dysfunction in multiple sclerosisFront Neur. 2012;3. doi:10.3389/fneur.2012.00074

  8. Butler E, Matcham F, Chalder T. A systematic review of anxiety amongst people with multiple sclerosis. Multiple Sclerosis and Related Disorders. 2016;10:145-168. doi:10.1016/j.msard.2016.10.003

  9. Podda J, Ponzio M, Messmer Uccelli M, et al. Predictors of clinically significant anxiety in people with multiple sclerosis: A one-year follow-up study. Multiple Sclerosis and Related Disorders. 2020;45:102417. doi:10.1016/j.msard.2020.102417

  10. Hanna M, Strober LB. Anxiety and depression in multiple sclerosis (MS): antecedents, consequences, and differential impact on well-being and quality of life. Multiple Sclerosis and Related Disorders. 2020;44:102261. doi:10.1016/j.msard.2020.102261

  11. Henry A, Tourbah A, Camus G, et al. Anxiety and depression in patients with multiple sclerosis: the mediating effects of perceived social support. Multiple Sclerosis and Related Disorders. 2019;27:46-51. doi:10.1016/j.msard.2018.09.039

  12. National Multiple Sclerosis Society. Emotional changes.

  13. Johns Hopkins Medicine. Multiple sclerosis and mental health: 3 common challenges.

  14. Vissicchio NA, Altaras C, Parker A, et al. Relationship between anxiety and cognition in multiple sclerosis. International Journal of MS Care. 2019;21(4):151-156. doi:10.7224/1537-2073.2018-027

  15. Kidd T, Carey N, Mold F, et al. A systematic review of the effectiveness of self-management interventions in people with multiple sclerosis at improving depression, anxiety and quality of life. PLoS ONE. 2017;12(10):e0185931. doi:10.1371/journal.pone.0185931

  16. Kolahkaj B, Zargar F. Effect of mindfulness-based stress reduction on anxiety, depression and stress in women with multiple sclerosis. Nurs Midwifery Stud. 2015;4(4):e29655. doi:10.17795/nmsjournal29655

  17. Hasanpour-Dehkordi A, Jivad N, Solati K. Effects of yoga on physiological indices, anxiety and social functioning in multiple sclerosis patients: a randomized trial. J Clin Diagn Res. 2016;10(6):VC01-VC05. doi:10.7860/JCDR/2016/18204.7916

By Heather Jones
Heather M. Jones is a freelance writer with a strong focus on health, parenting, disability, and feminism.