MS vs. Sacroiliitis: What Are the Differences?

Table of Contents
View All
Table of Contents

Although both multiple sclerosis (MS) and sacroiliitis can cause lower back or hip pain, they are otherwise unrelated conditions that differ significantly in biology, diagnosis, and treatment.

MS is an autoimmune disease of the brain and spinal cord. Pain in MS is related to either nerve damage or muscle/soft tissue damage that occurs as people with MS try to manage certain MS symptoms like spasticity (muscle stiffness and tightness), numbness, or imbalance.

Sacroiliitis is inflammation of one or both of the sacroiliac (SI) joints. These large joints are located on each side of the body and connect the lower spine to the hip bone. Various health conditions or issues may cause sacroiliitis, including arthritis, pregnancy, trauma, and infection.

This article will provide a general overview of MS and sacroiliitis and highlight key differences between the two conditions.

Person experiencing pain in low back

Nes / Getty Images


Pain in the lower back or hip is a hallmark symptom of sacroiliitis. In MS, lower back/hip pain is not a direct result of the disease but rather a secondary effect of people with MS trying to adapt to their symptoms.

Multiple Sclerosis

MS symptoms arise from interrupted nerve signaling between the brain and spinal cord and the rest of the body.

Pain is a common symptom of MS, and there are two types, which are:

  • Neuropathic pain occurs from nerve damage within the brain and spinal cord. An example of neuropathic pain in MS is a tingling or burning sensation in the feet and legs.
  • Musculoskeletal pain is muscle/soft tissue damage that develops as a person compensates for their MS symptoms. For example, a person may place more weight on one side of their body to compensate for a weak foot or stiff leg. This abnormal stress could lead to hip or lower back pain.

Other common symptoms of MS include:


The main symptom of sacroiliitis is a sharp or aching pain felt in the lower back, hip, and/or buttock. The severity of sacroiliitis pain depends on the degree of inflammation or injury to the joint.

Besides pain, other symptoms of sacroiliitis may include:

  • Radiation or movement of the pain to the leg, groin, or lower abdomen
  • Stiffness in the lower back/hip/buttock upon awakening or after sitting for a long time
  • Pain and stiffness that are relieved with physical activity
  • Whole-body (systemic) symptoms like fever or weight loss
Pain in Sacroiliitis
  • Stems from inflammation of the sacroiliac (SI) joint

  • May be accompanied by stiffness or whole-body symptoms like fever or weight loss

Pain in MS
  • Stems directly from nerve damage or indirectly from muscle/soft tissue damage

  • Usually accompanied by other MS symptoms, such as fatigue, spasticity (muscle stiffness), or weakness


MS is an autoimmune condition, and sacroiliitis may be caused by or associated with certain autoimmune conditions. Apart from this general similarity, MS and sacroiliitis are vastly distinct conditions.

Multiple Sclerosis

MS occurs when the immune system malfunctions and attacks nerve fibers and their protective myelin covering in the brain and spinal cord.

Experts do not know why the immune system launches such misguided attacks in MS. It's likely that a combination of factors, both genetic and environmental, are involved.

Some environmental factors potentially linked to MS development include:


The purpose of your SI joints is to facilitate absorption and transmission of any impact from your spine to the lower part of your body.

Inflammation of the sacroiliac joint may be caused by a variety of health conditions or factors.

Some of these conditions and factors are:

  • Ankylosing spondylitis (AS): This is a chronic autoimmune arthritis in which your immune system attacks your spine and sacroiliac joints.
  • Osteoarthritis: This is a noninflammatory type of arthritis that can cause degeneration (wear and tear) of the SI joint.
  • Trauma: Any injury (e.g., car accident or heavy lifting) that affects the lower back, hip, or buttocks may inflame the SI joint.
  • Pregnancy: Increased production of the pregnancy hormone relaxin makes the SI joint less stable and prone to injury. Also, the added weight of pregnancy can cause wear on the SI joint.
  • Infection: Rarely, bacteria can seed and infect the SI joint. This may be associated with pelvic trauma, intravenous (I)V drug use, or a urinary tract infection (UTI).


The estimated prevalence of sacroiliitis is around 0.3%–0.7% of the U.S. population. MS is seen in around 0.36% of the U.S. population.


There is no single test that can diagnose MS or sacroiliitis. Instead, healthcare providers pool data from a person's medical history, physical exam, and various tests to make the diagnosis.

Multiple Sclerosis

A neurologist, which is a doctor that specializes in diseases of the nervous system, diagnoses MS by reviewing a person's symptoms and performing neurological exam. Results from one or more of the following tests is also considered:


Sacroiliitis typically is diagnosed by a primary care provider, rheumatologist, physiatrist, or orthopedic surgeon using some combination of the following diagnostic tools and tests:

  • A musculoskeletal exam, in which your provider will inspect your spine, hip, and sacroiliac joints by pressing on and moving them
  • Imaging tests, like an X-ray or magnetic resonance imaging (MRI) of the pelvis/SI joint
  • Sacroiliac joint injection, in which your provider injects an anesthetic (numbing medicine) into the joint to see if the pain is relieved
  • Various blood tests, like HLA-B27 (a protein found in a large percentage of people with AS)


No cure yet has been found for MS. Sacroiliitis, on the other hand, may be reversed, depending on the underlying cause.

Multiple Sclerosis

The treatment of MS usually involves taking a disease-modifying treatment (DMT). DMTs are intended to help reduce MS relapses (flare-ups of symptoms) and slow disease progression.

Since DMTs are "big-picture" drugs, daily MS symptoms like pain, constipation, or spasticity are managed with a combination of lifestyle habits, medications, and rehabilitation therapies.

Specifically, lower back or hip pain in MS is usually treated with physical therapy, and an over-the-counter (OTC) pain medication like Tylenol (acetaminophen) or a nonsteroidal anti-inflammatory drug (NSAID) like Motrin or Advil (ibuprofen). A muscle relaxant like Kemstro (baclofen) may be prescribed if the pain stems from spasticity.


The treatment of sacroiliitis entails two main goals:

  • Reducing pain
  • Managing the underlying cause/condition

Pain is controlled through a combination of physical therapy and medications, including topical drugs like lidocaine (a numbing agent) and oral drugs like ibuprofen. A corticosteroid injection into the inflamed joint is also sometimes incorporated into the treatment plan.

Radiofrequency ablation (a minimally invasive procedure in which radio waves are used to heat and disrupt nerve function) may be tried if the other treatments don't work.

Joint fusion surgery (when the two bones of the SI joint are connected using a metal device) is generally considered a last resort treatment option for sacroiliitis.

Other treatments may be warranted depending on why a person develops sacroiliitis. For example, an anti-tumor necrosis factor (TNF) may be recommended if sacroiliitis is due to ankylosing spondylitis. Anti-TNF drugs, like Enbrel (etanercept), work to suppress or quiet inflammation in the body.


Healthy lifestyle behaviors may be helpful in protecting against or treating MS or sacroiliitis.

Multiple Sclerosis

The following lifestyle habits may help decrease MS disease activity or prevent MS onset in certain individuals:

  • Maintaining a healthy weight
  • Avoiding smoking
  • Participating in regular physical activity
  • Ensuring a sufficient vitamin D level through sun exposure or supplementation


Depending on the underlying cause, certain lifestyle behaviors can help prevent sacroiliitis onset or worsening.

For example, if you are pregnant, avoiding positions that place extra stress on the SI joint (e.g., crossing your legs) can help prevent sacroiliitis.

Likewise, if you have AS, engaging in exercise therapy can help reduce pain and protect against long-term SI joint damage.


Multiple sclerosis (MS) and sacroiliitis can both cause lower back or hip pain, although through unrelated means. Pain in MS stems directly from nerve damage or indirectly from muscle/soft tissue damage. The pain of sacroiliitis stems from inflammation of the sacroiliac joint.

Apart from the goal of easing pain, the diagnosis and treatment of MS and sacroiliitis are also distinct.

A Word From Verywell

Whether you are experiencing pain from sacroiliitis or MS, it's important to get it checked out by your healthcare provider. Each condition requires a careful assessment and thoughtful discussion about therapy options. As you navigate the challenges of MS or sacroiliitis, practice self-compassion and reach out to loved ones for support.

Frequently Asked Questions

  • Do autoimmune conditions cause sacroiliitis?

    Certain autoimmune conditions, like ankylosing spondylitis, may cause sacroiliitis. That said, non-autoimmune conditions, like osteoarthritis, can also cause sacroiliitis.

  • What diseases mimic sacroiliitis?

    Some conditions may mimic or resemble sacroiliitis, including Paget's disease (a condition with bone overgrowth), sarcoidosis (an inflammatory condition that produces lumps of cells in tissues), diffuse idiopathic skeletal hyperostosis (hardening of ligaments where they attach to the spine), lymphoma (cancer of the lymphatic system), and bone cancer.

  • Does MS cause joint inflammation?

    MS does not cause joint inflammation. People with MS may experience joint pain as a result of compensating for their MS symptoms (e.g., muscle weakness, walking/balance problems, or numbness).

  • Are MRI scans used to diagnose sacroiliitis?

    An X-ray of the pelvis is usually sufficient for diagnosing sacroiliitis. An MRI scan may be ordered if sacroiliitis does not show up on an X-ray but is still strongly suspected.

12 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. National MS Society. Pain and itching.

  2. Cavenaghi VB, Dobrianskyj FM, Sciascia do Olival G, et al. Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional studySao Paulo Med J. 2017;135(3):222-225. doi:10.1590/1516-3180.2016.0200270117

  3. Slobodin G, Hussein H, Rosner I, Eshed I. Sacroiliitis – early diagnosis is key. J Inflamm Res. 2018;11:339–344. doi:10.2147/JIR.S149494

  4. Zarghami A, Li Y, Claflin SB, van der Mei I, Taylor BV. Expert Rev Neurother. Role of environmental factors in multiple sclerosis. 2021;21(12):1389-1408. doi:10.1080/14737175.2021.1978843

  5. Baronio M, Sadia H, Paolacci S, et al. Etiopathogenesis of sacroiliitis: implications for assessment and management. Korean J Pain. 2020;33(4):294–304. doi:10.3344/kjp.2020.33.4.294

  6. Hermet M, Minichiello E, Flipo RM, et al. Infectious sacroiliitis: a retrospective, multicentre study of 39 adults. BMC Infect Dis. 2012;12:305. doi:10.1186/1471-2334-12-305

  7. Exarchou S, Redlung-Johnell I, Karlsson M. The prevalence of moderate to severe radiographic sacroiliitis and the correlation with health status in elderly Swedish men--the MrOS study. BMC Musculoskelet Disord 2013;14:352. doi:10.1186/1471-2474-14-352

  8. Wallin MT, Culpepper WJ, Campbell JD, et al. The prevalence of MS in the United States: A population-based estimate using health claims dataNeurology. 2019;92(10):e1029-e1040. doi:10.1212/WNL.0000000000007035

  9. McGinley MP, Goldschmidt CH, Rae-Grant AD. Diagnosis and treatment of multiple sclerosis: A reviewJAMA. 2021;325(8):765-779. doi:10.1001/jama.2020.26858

  10. Callhoff J, Sieper J, Weiß A, et al. Efficacy of TNFα blockers in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a meta-analysisAnn Rheum Dis. 2015;74(6):1241-8. doi:10.1136/annrheumdis-2014-205322

  11. Regnaux JP, Davergne T, Palazzo C, et al. Exercise programmes for ankylosing spondylitis. Cochrane Database Syst Rev. 2019;10(10):CD011321. doi:10.1002/14651858.CD011321.pub2

  12. Antonelli MJ, Magrey M. Sacroiliitis mimics: a case report and review of the literature. BMC Musculoskelet Disord. 2017; 18: 170. doi:10.1186/s12891-017-1525-1

By Colleen Doherty, MD
 Colleen Doherty, MD, is a board-certified internist living with multiple sclerosis.