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Eating Mushrooms May Lower Risks of Anxiety and Depression

mushrooms on table

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Key Takeaways

  • A large study found that people who eat mushrooms have a lower chance of anxiety and depression.
  • But eating more mushrooms doesn't necessarily cure depression, according to the researchers.
  • Mushrooms are rich in potassium and ergothioneine, which may help prevent oxidative stress and regulate nerve signals.

Magic mushrooms have earned all the hype recently, but regular mushrooms like white button, shiitake, and portobello also have tremendous health benefits. People who eat mushrooms may have a lower chance of developing anxiety and depression, according to a large observational study.

The study, published in the Journal of Affective Disorders, used dietary and mental health data from more than 24,000 participants to draw the association between mushroom consumption and lower odds of depression.

A majority of the previous studies on mushrooms and depression have been clinical trials with fewer than 100 participants, according to the study's press release.

"Mushrooms are a potent source of antioxidants, such as ergothioneine and potassium, which could reduce oxidative stress and inflammation. These are known to be risk factors for depression," says Xiang Gao, MD, PhD, a professor and director of the Nutritional Epidemiology Lab at The Pennsylvania State University and a co-author of the study.

Gao tells Verywell that people who incorporate mushrooms into their diet have a 43% lower likelihood of having depression, but his research team didn't find that eating more mushrooms would lower chances of depression further.

"We need more studies to replicate our findings and understand the potential biological mechanisms," Gao says, adding that the self-reported data didn't specify the types of mushrooms either.

Despite the drawbacks, this study does support other evidence that mushrooms should be included as part of a healthy diet.

Health Benefits of Mushrooms

The researchers chose to study mushrooms because they contain rich minerals. Previous research also indicated that mushroom intake may lower cancer risks.

"Ergothioneine is an amino acid with potent antioxidant properties present in high levels in mushrooms," Djibril Ba, PhD, MPH, a research data management specialist at Penn State College of Medicine and a study co-author, tells Verywell.

"This important antioxidant can only be obtained through dietary sources," he says. "Having high levels of ergothioneine in the body may help to prevent oxidative stress, which could also reduce the symptoms of depression."

Since other studies have shown a connection between high-sodium and low-potassium diets and increased depression chances, the researchers focused on the effects of potassium for this new observational study.

"Potassium is an important mineral that helps to regulate fluid in the body and nerve signals," Ba says. "Mushrooms contain potassium, which may help to lower the risk of anxiety."

In addition to ergothioneine and potassium, mushrooms offer many other health benefits as well, including lowering lipid levels.

Elizabeth Watt, RD, LDN, a registered dietitian at the UNC Wellness Center, says that mushrooms are a low-calorie, low-fat food rich in protein, fiber, antioxidants, vitamins, and minerals.

"Mushrooms are pretty high in Vitamin D, especially if it's being grown in an area with a lot of UV light. And that's one of those nutrients that most of us are walking around deficient in," she adds.

Watt recommends mushrooms as a meat source alternative, as one cup of white button mushrooms contains 2.2 g of protein. For example, you can dice up mushrooms and mix them into meatballs, or opt for a portobello mushroom instead of a beef burger.

"You are not going to get all of the nutrition you need out of just mushrooms," she says. "But it's another way to enhance your overall diet."

Some mushrooms—known as "magic mushrooms"—naturally contain psilocybin, a hallucinogenic substance that may be as power as antidepressants. But scientists are still learning about the different impacts of edible and magic mushrooms on depression.

Limited Research on Mushrooms and Depression

While current research doesn't prove that eating mushrooms will cure depression, this new study suggests that mushrooms are a nutritious food packed with vitamins and minerals that support overall health.

"The study adds to the growing list of potential health benefits of mushroom consumption," Ba says.

With more research, scientists may be able to say exactly how mushrooms could reduce depression risk.

"For those who are not taking prescription medication for depression, consider consuming mushrooms regularly," Ba says "It might be helpful but clinical trials are needed to provide more definitive effects."

What This Means For You

Mushrooms should not replace treatment for depression. Talk to your healthcare provider about what is right for you.


If you or a loved one are experiencing depression, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-4357. Free, confidential services are available 24/7. SAMHSA can help connect you with support groups and treatment options.

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2 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Ba D, Gao X, Al-Shaar L et al. Mushroom intake and depression: A population-based study using data from the US National Health and Nutrition Examination Survey (NHANES), 2005–2016Journal of Affective Disorders. 2021;294:686-692. doi:10.1016/j.jad.2021.07.080.

  2. Mrug S, Orihuela C, Mrug M, Sanders P. Sodium and potassium excretion predict increased depression in urban adolescentsPhysiol Rep. 2019;7(16). doi:10.14814/phy2.14213