Myrbetriq (Mirabegron) – Oral

What Is Myrbetriq?

Myrbetriq (mirabegron) is a prescription medication that treats overactive bladder (OAB) in adults. It belongs to a class of drugs known as beta-3 adrenergic receptor agonists.

Myrbetriq works by relaxing the smooth muscle surrounding your bladder, which allows you to hold more urine. By doing this, Myrbetriq relieves the symptoms of urinary frequency, urgency, and incontinence, which is the unintentional loss of control in releasing urine from the bladder. It can also be used to treat a pediatric bladder disorder called neurogenic detrusor overactivity (NDO).

Mirabegron comes in extended-release tablets (Myrbetriq) for oral use and extended-release granules for oral suspension (Myrbetriq Granules).

Drug Facts

Generic Name: Mirabegron

Brand Name(s): Myrbetriq, Myrbetriq Granules

Administration Route(s): Oral

Drug Availability: Prescription

Therapeutic Classification: Urinary frequency and incontinence agent

Available Generically: No

Controlled Substance: N/A

Active Ingredient: Mirabegron

Dosage Form(s): Extended-release tablet, extended-release granules for suspension

What Is Myrbetriq Used For?

Myrbetriq is often prescribed for adults to treat symptoms of OAB, including:

  • Urinary incontinence
  • Urinary urgency (a strong need to urinate right away)
  • Urinary frequency (urinating often)

It also treats NDO in children aged 3 years and older. Dosing schedules are approved for children weighing as little as 24.2 pounds. NDO is a type of bladder disorder related to neurological impairment in children.

Myrbetriq may be used alone or combined with another medication called solifenacin, which is available under the brand name Vesicare.

Mybretriq (Mirabegron) Drug Information

Verywell / Zoe Hansen

How to Take Myrbetriq

Myrbetriq is available as an oral tablet or liquid suspension. A healthcare provider will select which form and dose you should take based on your condition and body weight.

Your provider will prescribe the right dose for you. The prescribed dose is usually taken once a day. This medication is meant to be taken by mouth.

If you are prescribed the tablets, you can take your dose with or without food. Swallow the tablet whole and take it with water. Children who are prescribed the tablets should take their dose with food.

If you are taking the suspension (Myrbetriq Granules), you should take your dose within one hour of eating food. The pharmacist will dispense Myrbetriq Granules as a suspension and provide an oral dosing device for use. If you will not be using the suspension for two or more days, shake the bottle vigorously for one minute each day to ensure the granules are mixed well.


Store Myrbetriq and Myrbetriq Granules at a controlled room temperature, about 68–77 degrees Fahrenheit. For the tablets, keep the bottle closed and discard any unused medication that is out of date.

Use Myrbetriq Granules within 28 days after the pharmacist prepares the suspension. The expiration date will be on the bottle. After the expiration date, throw away any leftover medication.

Always carry your medication with you. If you are flying, keep the original prescription-labeled bottle or box in your carry-on bag. Don’t leave this medication in your car, especially if the temperature is very cold or hot.

How Long Does Myrbetriq Take to Work?

In clinical studies, Myrbetriq effectively treated symptoms of overactive bladder within four to eight weeks, depending on the dosage.

What Are the Side Effects of Myrbetriq?

This is not a complete list of side effects and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the Food and Drug Administration (FDA) at or 800-FDA-1088.

Like most medications, Myrbetriq can cause mild or severe side effects.

Common Side Effects

The most common side effects with Myrbetriq include:

Talk to your healthcare provider or pharmacist if any of these side effects don’t go away or become more severe.

Severe Side Effects

Call your healthcare provider right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Report Side Effects

Myrbetriq may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Myrbetriq Should I Take?

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The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For symptoms of an overactive bladder:
    • For oral dosage form (extended-release tablets alone):
      • Adults—At first, 25 milligrams (mg) once a day. Your doctor may increase the dose to 50 mg once a day after 4 to 8 weeks.
      • Children—Use and dose must be determined by your doctor.
    • For oral dosage form (extended-release tablets together with solifenacin succinate):
      • Adults—At first, 25 milligrams (mg) mirabegron and 5 mg solifenacin succinate once a day. Your doctor may increase the dose of mirabegron to 50 mg once a day after 4 to 8 weeks.
      • Children—Use and dose must be determined by your doctor.
  • For neurogenic detrusor overactivity:
    • For oral dosage form (extended-release tablets):
      • Children 3 years of age and older weighing 35 kilograms (kg) or more—At first, 25 milligrams (mg) once a day. Your doctor may increase the dose to 50 mg once a day after 4 to 8 weeks.
      • Children 3 years of age and older weighing less than 35 kg—Use the oral liquid for these patients.
      • Children younger than 3 years of age—Use and dose must be determined by your doctor.
    • For oral dosage form (extended-release suspension):
      • Children 3 years of age and older—Dose is based on body weight and must be determined by your doctor:
        • Weighing 35 kilograms (kg) or more—At first, 6 milliliters (mL) once a day. Your doctor may increase the dose to 10 mL once a day after 4 to 8 weeks.
        • Weighing 22 to less than 35 kg—At first, 4 mL once a day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 8 mL per day.
        • Weighing 11 to less than 22 kg—At first, 3 mL once a day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 6 mL per day.
      • Children younger than 3 years of age or weighing less than 11 kg—Use and dose must be determined by your doctor.


Your healthcare provider may adjust your dose based off of liver and kidney function.

Missed Dose

If a dose of Myrbetriq is missed or spit out, take it as soon as possible unless more than 12 hours have passed. If 12 hours have passed, skip the missed dose and take the next dose at the regularly scheduled time. Do not take extra to make up for the missed dose. Doing so can increase your risk for side effects.

Overdose: What Happens If I Take Too Much Myrbetriq?

Taking too much Myrbetriq can lead to heart palpitations (fluttering or pounding heart) or increased heart rate. Let your healthcare provider know if you think you've taken too much Myrbetriq.

What Happens If I Overdose on Myrbetriq?

If you think you or someone else may have overdosed on Myrbetriq, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Myrbetriq, call 911 immediately.


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It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may increase your blood pressure. You will need to have your blood pressure measured while you are using this medicine. If you notice any change in your blood pressure, call your doctor right away.

This medicine may increase your risk of having urinary retention (trouble passing urine or not fully emptying the bladder), especially when using another medicine (eg, solifenacin succinate). Check with your doctor if you have a decrease in urine volume, decrease in the frequency of urination, difficulty in passing urine (dribbling), or painful urination.

This medicine may cause a serious allergic reaction, called angioedema, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals, rouble breathing, or trouble swallowing after using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

What Are Reasons I Shouldn’t Take Myrbetriq?

There are a few reasons why your healthcare provider may not choose Myrbetriq as part of your treatment, including:


A person should not take Myrbetriq if they are allergic to the ingredients.


Myrbetriq may cause harm to the fetus. It is best to talk to your provider if you are pregnant or plan to become pregnant so that they can decide the best option for you.


It isn’t known if Myrbetriq passes into human milk, but it can potentially cause serious harm to a breastfed child. Talk with your provider if you are breastfeeding to discuss the best treatment plan.

Older Adults

A person aged 65 years or older often processes drugs more slowly. A lower dose or different schedule may be required.

Other Health Conditions

In specific individuals, the body may handle Myrbetriq differently. Inform your healthcare provider if you have:

What Other Medications May Interact With Myrbetriq?

Myrbetriq can interfere with the metabolism of certain medications and dose adjustments may be required. Here are a few examples of those medications:

  • Digox (digoxin)
  • Coumadin (warfarin)
  • Tricyclic antidepressants, such as amitriptyline and doxepin
  • Beta-blockers, such as Inderal (propranolol) and Tenormin (atenolol)
  • Zoloft (sertraline)
  • Paxil (paroxetine)
  • Haldol (haloperidol)
  • Mellaril (thioridazine)

This list does not include all drugs that can interact with Myrbetriq. Before using Myrbetriq, tell your healthcare provider about all of the prescription medications, OTC medications, vitamins, supplements, or herbs you are taking. This will help you avoid potential interactions. If you have any questions about drug interactions, speak with a healthcare professional.

What Medications Are Similar?

There are a few other medications that are also used to treat OAB, including: 

  • Ditropan XL and Ditropan IR (oxybutynin)
  • Detrol (tolterodine)
  • Vesicare (solifenacin)

Ditropan XL and Ditropan IR

Oxybutynin is a urinary antispasmodic medication that works by relaxing bladder smooth muscle. It is often prescribed to treat OAB in adults, as well as NDO. Ditropan XL is available as an oral tablet. The most common side effects are urinary tract infection, trouble sleeping, dry mouth, and dizziness.


Tolterodine is another urinary antispasmodic that works by relaxing bladder smooth muscle to treat OAB. Detrol is available in tablet and capsule form. Common side effects include dry mouth, headache, dizziness, and constipation.


As another urinary antispasmodic, solifenacin works similarly to Ditropan IR (oxybutynin) and Detrol (tolterodine). It is often prescribed to treat OAB. The most common side effects include dry mouth, constipation, blurred vision, and urinary retention. This medication is sometimes used in combination with Myrbetriq.

This list is a list of examples of medications used to treat OAB. It is not necessarily a list of drugs recommended to take with Myrbetriq. Ask your healthcare provider if you have any questions.

Frequently Asked Questions

  • What is Myrbetriq used for?

    Myrbetriq works by allowing your bladder to hold more urine (relaxing the smooth muscle around your bladder). This helps Myrbetriq treat overactive bladders.

  • What are the side effects of Myrbetriq?

    The most common side effects are dry mouth, dizziness, and constipation. Myrbetriq also has the potential for serious side effects, such as an allergic reaction and atrial fibrillation (irregular, often rapid heartbeat). If you are experiencing any serious side effects, call your healthcare provider. Call 911 if you are experiencing a medical emergency or life-threatening symptoms.

  • How do I stop taking Myrbetriq?

    Do not stop taking Myrbetriq without first speaking with your provider. They will be able to help come up with a plan for the safest way to stop taking the medication.

How Can I Stay Healthy While Taking Myrbetriq?

When used correctly, Myrbetriq is a safe and effective medication that can help control OAB.

Myrbetriq is generally well tolerated, with most side effects being mild. In some cases, it can cause more serious side effects such as allergic reactions or high blood pressure, so it is important to monitor how you feel while taking this medication.

OAB can be a debilitating condition for some. However, you can work with your healthcare provider to find an appropriate treatment for you. Tell your healthcare provider of your other health conditions and any prescription medications, OTC medications, supplements, or herbs you are taking. Your provider can decide what drug and dose work best for you.

In addition to taking Myrbetriq, there are other ways you can cope with OAB. Most importantly, remember to be consistent in whatever therapy you are using to control your symptoms.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare professional. Consult your doctor before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

6 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. U.S. Library of Medicine. DailyMed. Myrbetriq.

  2. Food and Drug Administration. Myrbetriq label.

  3. Food and Drug Administration. FDA Approves New indication for DRug to Treat Neurogenic Detrusor Overactivity in Pediatric Patients.

  4. U.S. Library of Medicine. DailyMed. Ditropan XL - oxybutynin.

  5. U.S. Library of Medicine. DailyMed. Detrol - tolterodine.

  6. U.S. Library of Medicine. DailyMed. Vesicare.

By Kaylea Swearingen, PharmD
Kaylea Swearingen is a registered pharmacist and health and wellness writer.