Natural Treatments for Endometriosis

11 Alternative Therapies to Alleviate Pain and Cramping

Endometriosis is a chronic, often painful condition in which the tissue that normally lines the uterus (called the endometrium) starts growing outside the uterus. The overgrowth most commonly affects the fallopian tubes, ovaries, and pelvic lining but can also spread beyond the pelvic area.

Endometriosis is commonly treated with hormone therapy, surgery, pain medications, and lifestyle changes, but because it can be so difficult to treat, many women will turn to natural therapies to support the medical treatments prescribed by their doctors.

endometriosis signs and symptoms
Illustration by Emily Roberts, Verywell

Treatment Goals

Alternative therapies work both to alleviate the symptoms of endometriosis as well as address the underlying causative factors. As a general rule, there is little scientific evidence to support the use of any alternative therapy in treating endometriosis. With that said, the potential harms tend to be low, so they generally won't make things worse.

Symptoms of endometriosis include:

  • Painful periods, including pelvic pain and cramping
  • Lower abdominal or low back pain
  • Sharp, deep pain during ovulation, sexual intercourse, bowel movements, or urination
  • Shooting pains (sciatica) during menstruation
  • Heavy menstrual periods
  • Bleeding in between periods
  • Indigestion, diarrhea, constipation, or nausea
  • Infertility

To avoid complications, advise your doctor if you intend to use natural therapies of any sort. In this way, your condition can be monitored and steps taken should unforeseen side effects or interactions occur.


Estrogen is a female hormone that regulates the normal growth of the endometrium. Research shows that the dysregulation of estrogen may contribute to the development of endometriosis.

A group of plant-based chemicals called isoflavones may help reduce the symptoms of endometriosis by inhibiting aromatase, an enzyme that converts male hormones (androgens) to estrogens. Good food sources of isoflavones include celery, parsley, soybeans, chickpeas, fava beans, pistachios, and peanuts.

Similarly, an organic compound called indoles found in broccoli, cauliflower, cabbage, kale, Brussels sprouts, and bok choy have mild anti-estrogen effects that may be beneficial to women with endometriosis.

Low-Fat Diet

Some studies suggest that long-term exposure to environmental chemicals called dioxins and polychlorinated biphenyls (PCBs) may increase the risk and severity of endometriosis.

One way to reduce the intake of these toxins is to cut back on saturated fats, especially high-fat dairy and red meat. Dioxin and PCBs both accumulate in animal-based fats, which can readily be passed to humans in foods.

Several studies have also shown that red meat is an independent risk factor for endometriosis, while an increase in consumption of fresh fruit and vegetables is associated with a decreased risk.

Progesterone Cream

Alternative practitioners will often recommend progesterone cream to treat the symptoms of endometriosis.

It is believed that progesterone cream inhibits the proliferation of endometrial cells and the development of blood vessels (angiogenesis) that feed the uterine growth. By inhibiting these processes, the endometrial overgrowth may be significantly reduced along with the accompanying pain.

Progesterone cream is derived from either soy or Mexican wild yam. A plant-based steroid called diosgenin is extracted in a lab and converted to a bioequivalent form of progesterone. Wild yam cream is often sold as "natural progesterone," a marketing ploy that is misleading since the diosgenin content cannot be converted in the body to progesterone.

Progesterone cream is available from compounding pharmacies or at some regular drugstores. It can be applied to the wrists, inner arms, inner thighs, or upper chest at a dose recommended by your doctor.

It is important that the treatment to be medically supervised because too much progesterone can cause mood changes, depression, water retention, weight gain, and abnormal menstrual bleeding.

Although available over-the-counter, progesterone cream has not been approved for use by the U.S. Food and Drug Administration (FDA).

Omega-3 Fatty Acids

Prostaglandins are a class of complex fatty acids that are largely responsible for menstrual cramps and pain caused by endometriosis. There are "good" prostaglandins that alleviate inflammation as well as "bad" prostaglandins that do promote inflammation. Too much of one or too little of the other can trigger pain.

Omega-3 fatty acids found in fatty fish such as salmon, mackerel, sardines, and anchovies are believed to be beneficial to women with endometriosis as they are converted in the body to anti-inflammatory prostaglandins. At the same time, they appear to suppress the production of inflammatory prostaglandins derived from saturated fats in dairy and red meat.

An increased intake of omega-3 fatty acids—most specifically a compound called eicosapentaenoic acid (EPA) found in fish oil—can alter the balance of prostaglandins and alleviate many of the inflammatory symptoms of endometriosis.

The jury remains split on how robust these dietary interventions are, although studies have shown that women with high concentrations of EPA are 82% less likely to have endometriosis compared to women with low EPA levels.

In addition to eating fatty fish, you can obtain omega-3 fatty acids from fish oil supplements over the counter sold in capsule form.


Chamomile, often embraced for its "calming" effects, has long been used as a home remedy for premenstrual syndrome (PMS). These same effects are assumed to be useful in providing the generalized relief of cramps and pain caused by endometriosis.

Research has suggested that the effects may be more direct than previously imagined. According to a 2018 study published in the Journal of Cellular Physiology, chamomile contains an isoflavone known as chrysin which appears to trigger apoptosis (cell death) in uterine tissues that have grown out of control.

The test tube study suggested that chrysin found in chamomile and other substances (such as honey) may one day lead to the development of drugs that can relieve endometriosis symptoms. Further research is needed to see if the same results can be replicated in humans.


Resveratrol is a plant-based nutrient mainly found in grapes, peanuts, and mulberries. Resveratrol is believed to treat endometriosis by inhibiting aromatase (associated with estrogen activity) and COX-2 enzymes (associated with pain).

Animal research has shown that resveratrol implants in rats reduced the number and size of endometrial lesions by 60%. Whether the same can be achieved by eating resveratrol-rich foods has yet to be proven.

A small 2016 study published in the Journal of Clinical Endocrinology and Metabolism reported that women provided 1,500 milligrams of resveratrol per day in tablet form had a 23% reduction in blood testosterone levels after three months. What the supplement did not reduce, however, was the inflammation that promotes endometriosis symptoms.


Turmeric is a mainstay of naturopathic medicine and a spice that may offer significant benefits to women with endometriosis.

Turmeric contains an anti-inflammatory and antioxidant compound known as curcumin that has been shown to slow endometrial cell proliferation in test tube studies. It appears to do so by inhibiting the production of estradiol, the strongest of the three types of human estrogen.

Further research is needed to determine whether the oral use of turmeric can render a therapeutic effect in women with endometriosis. At present, the evidence is lacking.

While generally regarded as safe, the FDA warns that some imported turmeric supplements were found to contain high levels of lead. To ensure safety, only buy supplements certified by the U.S. Pharmacopeia (USP), NSF International, or ConsumerLab.

Green Tea

Green tea has similar properties to progesterone in that it is a potent inhibitor of aromatase. Moreover, it an anti-angiogenic and suppresses the development of tiny blood vessels that feed endometrial overgrowth and promote inflammation.

Green tea appears to do so by blocking vascular endothelial growth factor C (VEGFC), a protein released by red blood cells. A 2018 study in the journal Human Reproduction reported that lab mice implanted with a green tea derivative achieved significant reductions in endometrial vascularization (blood vessel growth) compared to mice treated with a placebo.

It is unclear if drinking green tea offers any of the same benefits.


Acupuncture involves the insertion of tiny needles in the skin, mainly to treat pain. A 2017 review of studies published in the journal PLoS ONE found evidence, albeit slight, that acupuncture can reduce abdominal and pelvic pain and the size of the endometrial overgrowth in women with endometriosis.

Despite the positive findings, the quality of the studies was generally poor with largely arbitrary or subjective measures. Of the 10 studies included, only one was placebo-controlled.

Massage Therapy

Massage therapy is believed to relieve the symptoms of endometriosis in two ways: By gently releasing adhesions that stick uterine tissues together and by alleviating stress that can amplify pain sensations and trigger uterine spasms.

A small study conducted in 2010 reported that 23 women with endometriosis had a significant reduction in pelvic pain after six weeks of massage therapy. In total, the women were given 20 twenty-minute sessions focusing on the abdomen, sides, and base of the spine (sacrum). No other treatments were prescribed during the six-week study.

Chinese Herbs

Practitioners of traditional Chinese medicine (TCM) typically used a combination of herbs to treat uterine conditions like endometriosis. Endometriosis is not categorized as a disease in TCM but is rather described as a "blood stasis syndrome" characterized by the formation of abdominal lumps.

A comprehensive review of studies published in the Cochrane Database of Systematic Reviews found that Chinese herbs used to treat blood stasis appeared comparable to the steroid gestrinone in relieving endometriosis pain after laparoscopic surgery.

When used outside of surgery, the Chinese herbs (taken orally and in enema form) appeared to be just as effective as the synthetic androgen danazol in providing endometriosis pain relief.

Despite the positive findings, the researcher concluded that "more rigorous research is required to accurately assess the potential role of (Chinese herbs) in treating endometriosis."

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  1. Carpinello OJ, Sundheimer LW, Alford CE, et al. Endometriosis. [Updated 2017 Oct 22]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-. Available from:

  2. [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Treatment options for endometriosis. 2008 Feb 25 [Updated 2017 Oct 19]. Available from:

  3. Muñoz-Hernando L, Muñoz-Gonzalez JL, Marqueta-Marques L, et al. Endometriosis: alternative methods of medical treatmentInt J Womens Health. 2015;7:595‐603. Published 2015 Jun 11. doi:10.2147/IJWH.S78829

  4. Schwartz ASK, Gross E, Geraedts K, et al. The use of home remedies and complementary health approaches in endometriosisReprod Biomed Online. 2019;38(2):260‐271. doi:10.1016/j.rbmo.2018.10.009

  5. Parasar P, Ozcan P, Terry KL. Endometriosis: epidemiology, diagnosis and clinical management. Curr Obstet Gynecol Rep. 2017;6(1):34-41. doi:10.1007/s13669-017-0187-1

  6. Marquardt RM, Kim TH, Shin JH, Jeong JW. Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?Int J Mol Sci. 2019;20(15):3822. Published 2019 Aug 5. doi:10.3390/ijms20153822

  7. Mori T, Ito F, Koshiba A, et al. Aromatase as a target for treating endometriosis. J Obstet Gynaecol Res. 2018;44(9):1673-81. doi:10.1111/jog.13743

  8. Emmett JH. Nutritional protocol for endometriosis. J Nutr Diet. 2017;1(Suppl 1):104

  9. Bruner-tran KL, Osteen KG. Dioxin-like PCBs and endometriosis. Syst Biol Reprod Med. 2010;56(2):132-46. doi:10.3109/19396360903381023

  10. Buggio L, Barbara G, Facchin F, Frattaruolo MP, Aimi G, Berlanda N. Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care. Int J Womens Health. 2017;9:281-293. doi:10.2147/IJWH.S119724

  11. LI Y, Adur MK, Kanna A, et al. Progesterone alleviates endometriosis via inhibition of uterine cell proliferation, inflammation and angiogenesis in an immunocompetent mouse model. PLoS One. 2016;11(10):e0165347. doi:10.1371/journal.pone.0165347

  12. Fugh-Berman A. Wild Yam Cream, Diosgenin, and Natural Progesterone: What Can They Really Do for You?. National Women’s Health Network. January/February Newsletter 1999.

  13. Liagre B, Vergne-Salle P, Corbiere C, Charissoux JL, Beneytout JL. Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpressionArthritis Res Ther. 2004;6(4):R373‐R383. doi:10.1186/ar1199

  14. Fugh-Berman A, Bythrow J. Bioidentical hormones for menopausal hormone therapy: variation on a themeJ Gen Intern Med. 2007;22(7):1030‐1034. doi:10.1007/s11606-007-0141-4

  15. U.S. Food and Drug Administration. Sec. 310.530 Topically applied hormone-containing drug products for over-the-counter (OTC) human use. Updated April 1, 2019.

  16. Monday I, Anthony P, Olunu E, et al. Prevalence and Correlation between Diet and Dysmenorrhea among High School and College Students in Saint Vincent and GrenadinesOpen Access Maced J Med Sci. 2019;7(6):920‐924. Published 2019 Mar 28. doi:10.3889/oamjms.2019.205

  17. Khanaki K, Nouri M, Ardekani AM, et al. Evaluation of the relationship between endometriosis and omega-3 and omega-6 polyunsaturated fatty acidsIran Biomed J. 2012;16(1):38‐43. doi:10.6091/ibj.1025.2012

  18. Hopeman MM, Riley JK, Frolova AI, Jiang H, Jungheim ES. Serum polyunsaturated fatty acids and endometriosis. Reprod Sci. 2015;22(9):1083-7. doi:10.1177/1933719114565030

  19. Khalesi ZB, Beiranvand SP, Bokaie M. Efficacy of Chamomile in the Treatment of Premenstrual Syndrome: A Systematic ReviewJ Pharmacopuncture. 2019;22(4):204‐209. doi:10.3831/KPI.2019.22.028

  20. Ryu S, Bazer FW, Lim W, Song G. Chrysin leads to cell death in endometriosis by regulation of endoplasmic reticulum stress and cytosolic calcium level. J Cell Physiol. 2019;234(3):2480-90. doi:10.1002/jcp.26770

  21. Lekli I, Ray D, Das DK. Longevity nutrients resveratrol, wines and grapesGenes Nutr. 2010;5(1):55‐60. doi:10.1007/s12263-009-0145-2

  22. Bruner-Tran KL, Osteen KG, Taylor HS, Sokalska A, Haines K, Duleba AJ. Resveratrol inhibits development of experimental endometriosis in vivo and reduces endometrial stromal cell invasiveness in vitro. Biol Reprod. 2011;84(1):106-12. doi:10.1095/biolreprod.110.086744

  23. Banaszewska B, Wrotyńska-Barczyńska J, Spaczynski RZ, Pawelczyk L, Duleba AJ. Effects of resveratrol on polycystic ovary syndrome: a double-blind, randomized, [lacebo-controlled trial. J Clin Endocrinol Metab. 2016;101(11):4322-8. doi:10.1210/jc.2016-1858

  24. Arablou T, Kolahdouz-Mohammadi R. Curcumin and endometriosis: Review on potential roles and molecular mechanismsBiomed Pharmacother. 2018;97:91‐97. doi:10.1016/j.biopha.2017.10.119

  25. Zhang Y, Cao H, Yu Z, Peng HY, Zhang CJ. Curcumin inhibits endometriosis endometrial cells by reducing estradiol production. Iran J Reprod Med. 2013;11(5):415-22.

  26. U.S. Food and Drug Administration. Import Alert 28-13. November 21, 2019.

  27. Pavone ME, Bulun SE. Aromatase inhibitors for the treatment of endometriosisFertil Steril. 2012;98(6):1370‐1379. doi:10.1016/j.fertnstert.2012.08.053

  28. Xu H, Lui WT, Chu CY, Ng PS, Wang CC, Rogers MS. Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model. Hum Reprod. 2009;24(3):608-18. doi:10.1093/humrep/den417

  29. Xu Y, Zhao W, Li T, Zhao Y, Bu H, Song S. Effects of acupuncture for the treatment of endometriosis-related pain: a systematic review and meta-analysis. PLoS ONE. 2017;12(10):e0186616. doi:10.1371/journal.pone.0186616

  30. Valiani M, Ghasemi N, Bahadoran P, Heshmat R. The effects of massage therapy on dysmenorrhea caused by endometriosis. Iran J Nurs Midwifery Res. 2010;15(4):167-71.

  31. Shan J, Cheng W, Zhai DX, et al. Meta-Analysis of Chinese Traditional Medicine Bushen Huoxue Prescription for Endometriosis TreatmentEvid Based Complement Alternat Med. 2017;2017:5416423. doi:10.1155/2017/5416423

  32. Flower A, Liu JP, Lewith G, Little P, Li Q. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2012;(5):CD006568. doi:10.1002/14651858.CD006568.pub3