Cancer Lymphoma Non-Hodgkin Lymphoma Print Nodal Marginal Zone B-Cell Lymphoma Overview By Indranil Mallick, MD twitter linkedin Indranil Mallick, MD, DNB, is a radiation oncologist with a special interest in lymphoma. Learn about our editorial process Indranil Mallick, MD Medically reviewed by Medically reviewed by Doru Paul, MD on May 07, 2018 Doru Paul, MD, is triple board-certified in medical oncology, hematology, and internal medicine. He is an associate professor of clinical medicine at Weill Cornell Medical College and attending physician in the Department of Hematology Oncology at the New York Presbyterian Weill Cornell Medical Center. Learn about our Medical Review Board Doru Paul, MD Updated on March 10, 2020 Lymphoma Overview Symptoms Causes Diagnosis Treatment Coping STEVE GSCHMEISSNER / Getty Images Nodal marginal zone B-cell lymphoma is a type of non-Hodgkin lymphoma (NHL). It has also been called monocytoid B cell lymphoma or MZL. Lymphomas are cancers of lymph cells, a type of blood cell. There are two main categories—Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). Nodal marginal zone B-cell lymphoma is one of the uncommon types of NHL. It is a type of low-grade (or slow-growing) lymphoma that arises from B-cells and mainly affects lymph nodes. In addition, nodal marginal zone B-cell lymphoma mainly affects older individuals. There are no known direct risk factors for this lymphoma but a few risk factors associated with lymphomas in general. Symptoms The most common symptom of this lymphoma is the enlargement of lymph nodes. Enlarged nodes become apparent as swellings in the neck, armpits or groin. This may be the only symptom, or there may be other associated symptoms and signs like fever and weight loss. Diagnosis All lymphomas are diagnosed with a biopsy. A lymph node biopsy removes a small amount of tissue from the enlarged nodes and this is examined under the microscope. The pattern of cells seen under the microscope and tests for specific lymphoma markers will diagnose it as this particular type of non-Hodgkin lymphoma. After a lymph node biopsy diagnoses this lymphoma, several tests are performed to find out how much this lymphoma has spread in the body. Tests may include CT scans, blood tests, and a bone marrow test. These tests are useful in determining the staging and prognosis of the lymphoma. Staging and Prognosis Depending on the extent of lymphoma at diagnosis, the disease is grouped into one of four stages. Most individuals with nodal marginal zone B-cell lymphoma are diagnosed at an early stage (when the lymphoma is restricted to one or a few lymph node areas). The stage and other factors like age, fitness, and blood test results determine the disease outlook or prognosis. Unless the disease has spread extensively, this lymphoma has a good prognosis with a favorable outcome after treatment. Treatment Nodal marginal zone B-cell lymphoma is a slow-growing lymphoma. The treatment of this lymphoma is on the same lines as that of follicular lymphoma, the most common type of low-grade non-Hodgkin lymphoma (NHL). If there are no symptoms, watching and waiting may be the approach used, with regular monitoring. Once symptoms develop, the main treatment is with chemotherapy, and a number of drugs can be used. The final treatment is decided after assessing numerous factors including the stage and prognosis, the severity of symptoms and cost of treatment. The majority of individuals with this lymphoma have a good response to treatment and a chance of long-term disease control. Was this page helpful? Thanks for your feedback! Limiting processed foods and red meats can help ward off cancer risk. These recipes focus on antioxidant-rich foods to better protect you and your loved ones. Sign up and get your guide! Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. van den Brand M, van Krieken JH. Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review. Haematologica. 2013;98(7):1003–1013. doi:10.3324/haematol.2012.083386 Additional Reading American Cancer Society. Types of non-Hodgkin lymphoma. National Cancer Institute. Adult non-Hodgkin lymphoma treatment–for health professionals (PDQ®).