Heart Health High Blood Pressure Treatment What to Know About Norvasc (Amlodipine) A medication for treating high blood pressure and stable angina By Rachael Zimlich, BSN, RN Rachael is a freelance healthcare writer and critical care nurse based near Cleveland, Ohio. Learn about our editorial process Rachael Zimlich, BSN, RN Medically reviewed by Medically reviewed by Jeffrey S. Lander, MD on November 14, 2020 twitter linkedin Jeffrey S. Lander, MD, is a board-certified cardiologist and the President and Governor of the American College of Cardiology, New Jersey chapter. Learn about our Medical Review Board Jeffrey S. Lander, MD on November 14, 2020 Print Table of Contents View All Table of Contents Uses Before Taking Dosage Modifications Side Effects Warnings and Interactions Norvasc (amlodipine) is a prescription medication used most often to treat hypertension (high blood pressure). It is prescribed either as a standalone medication or in combination with other therapies. It can also be used to treat stable angina (chest pain). Norvasc belongs to a class of medications called calcium channel blockers that work by affecting the amount of calcium that enters the cell. Calcium causes more forceful contraction of the heart and arteries; blocking the entry of calcium into these cells can help them to relax, thereby lowering blood pressure. Besides being sold as Norvasc, in the United States amlodipine is sold under the brand name Katerzia as well as generically. It is available in pill or liquid forms. Uses There are three uses for Norvasc approved by the Food and Drug Administration (FDA). It may be used to treat: Hypertension (ages 6 and older) Chronic stable angina (chest pain) Vasospastic angina (chest pain) Off-Label Uses Although not approved by the FDA for this use, Norvasc is sometimes prescribed to treat Raynaud's phenomenon. Before Taking Before your doctor prescribes Norvasc for you, you will have been diagnosed with hypertension severe enough to require medication. They will go over your medical history, current health problems, allergies, and other medications or supplements you may be taking. They also will assess your cardiac health with a physical exam, by taking your vital signs, and possibly with an electrocardiogram or echocardiogram. [Standard disclaimer: Talk to your doctor about all medications, supplements, and vitamins that you currently take. While some drugs pose minor interaction risks, others may outright contraindicate use or prompt careful consideration as to whether the pros of treatment outweigh the cons in your case.] Precautions and Contraindications Before taking this or any medication, review the precautions and contraindications with your doctor to be sure you don’t have any conditions that might prevent this medication from being right for you. Norvasc should not be taken by anyone who has a hypersensitivity to it or any component of it. Make sure you doctor is aware if you have or have had: Chest pain A heart attack Low blood pressure (hypotension) Swelling in your hands or feet (peripheral edema) Aortic stenosis Heart failure Hypertrophic cardiomyopathy Liver disease (individuals who have liver disease may be able to take Norvasc but must do so in individualized dosages) Norvasc is a category C medication for pregnant women, meaning there is some evidence it could have an adverse effect on a developing baby. At the current time, caution is advised during pregnancy if taking amlodipine, since there is inadequate human data available to thoroughly assess risk. Amlodipine should only be used in pregnancy if the benefits outweigh the risks. Norvasc crosses the placenta and is present in breastmilk. Caution is advised while breastfeeding. There is only limited human data that suggest no known risk of infant harm. Tell your doctor if you're pregnant or nursing before you begin taking Norvasc (or any new medication). Other Calcium Channel Blockers If it turns out Norvasc (or another form of amlodipine) doesn't work for you, there are other medications in the same class for treating high blood pressure: Diltiazem (Cardizem, Tiazac, others) Felodipine Isradipine Nicardipine Nifedipine (Adalat CC, Procardia) Nisoldipine (Sular) Verapamil (Calan, Verelan) Dosage How your doctor prescribes Norvasc will depend on what you're being treated for. Standard dosages are based on specific conditions for adults. Hypertension: Initially 2.5 milligrams (mg) to 5 mg once daily, increased to 10 mg if necessary. Chronic stable angina or vasospastic angina: 5 mg to 10 mg once daily. Reynaud’s phenomenon: 5 mg once daily, increased once every four weeks as needed. [All listed dosages are according to the drug manufacturer. Check your prescription and talk to your doctor to make sure you are taking the right dose for you.] Modifications For seniors and children, standard dosages also vary: Seniors with hypertension: 2.5 mg initially, once per day Seniors with angina: 5 mg initially, once per day Children under 6 with hypertension: 0.1 mg/kg/dose once daily, increased slowly, with a daily maximum dose of 0.6 mg/kg/dose Children over 6 with hypertension: 2.5 mg per day initially, increased slowly, with a daily maximum of 10 mg Children over age 6 with Reynaud’s phenomenon: 2.5 mg to 10 mg per day Adult with liver disease also require special dosing—typically 2.5 mg initially for hypertension and 5 mg per day for angina. How to Take and Store It's important to carefully follow your doctor's instructions for taking Norvasc and to keep other considerations in mind as well: This medication can be taken with or without food. Take Norvasc at the same time every day. If you miss a dose, take Norvasc as soon as you realize it, unless it's nearly time for the next dose, in which case skip the missed dose: do not take a double dose. Store Norvasc in its original container, away from moisture, heat, or direct light, and out of sight and reach of children. Do not stop taking this medication suddenly. Speak with your doctor if you feel you need to quit taking Norvasc for any reason first. Side Effects As with all medications, Norvasc is associated with certain side effects. Common Tell your doctor if while taking Norvasc you experience: Headache Dizziness Sweating Tender or bleeding gums Indigestion or upset stomach Stomach cramps Severe In the event you develop any of the following symptoms, call your doctor immediately. Swelling in the ankles or feet Chest pain or tightness Black, tarry stools Blood in urine Blurred vision Confusion Enlarged neck veins Racing heart Hives or rash Yellow (jaundiced) eyes or skin Warnings and Interactions Norvasc is known to interact with both Crixivan (indinavir) and Priftin (rifapentine). If you take either of these, your doctor may adjust your dosage of both or either drug for safety and effectiveness. You should not take Norvasc if you take any of the following medications: Abametapir Bromperidol Conivaptan Pimozide Systemic fusidic acid There are many medications that may interact with Norvasc but that do not necessarily preclude taking it. Your doctor may monitor your closely and/or adjust your dose if you also take: Alfuzosin Alpha-1 blockers Amifostine Amphetamines Antifungal agents Antihepaciviral combination products Antipsychotic agents Aprepitant Atosiban Barbituates Benperidol Brigatinib Brimotidine Calcium channel blockers Calcium salts Carbamazepine Clofazimine Clopidopgrel Cyclosporine CYP3A4 inducers CYP3A4 inhibitors Dabrafenib Dapoxetine Deferasirox Dexamethylphenidate Diazoxide Dofetilde Duloxetine Duvelisib Efavirenz Enzalutamide Erdafitnib Flibanserin Fluconazole Fosaprepitant Fosnetupitant Fosphenytoin Idelaisib Ivosidenib Larotrectinib Lembroexant Levadopa-containing medications Lomitapide Lormetazepam Lovastatin Macrolide antibiotics Magnesium salts Melatonin Methylphenidate Mifepristone Mitotane Molsidomine Naftopidil Netupitant Neuromuscular-blocking agents Nicegoline Nicorandil Nimopidine Nitroprusside Obinutuzumab Palbociclib Pentoxifylline Phenytoin Pholcodine Phosphodiesterase Pimozide Prostacyclin analogues Quinagolide Quinidine Rifamycin Sarilumab Simaprevir Simvastatin Sincalide Stiripentol Tacrolimus Tocilizumab Ubrogepant Yohimbine Was this page helpful? Thanks for your feedback! Looking to start a diet to better manage your high blood pressure? Our nutrition guide can help. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. UpToDate. Amlodipine: Drug information. 2020. Mayo Clinic. Amlodipine. Sept 1, 2020. Mayo Clinic. Calcium channel blockers. 2019.