How Opioid Induced Constipation Is Diagnosed

Opioid-induced constipation is a common condition that results from taking opioid medications for pain management. Constipation describes infrequent bowel movements or experiencing hard, dry stool that is difficult to pass. Opioid-induced constipation is usually diagnosed with a thorough history and physical exam.

This article will describe the tools used to diagnose opioid-induced constipation and list other common causes of constipation. 

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Self-Checks/At-Home Testing

Opioid-induced constipation may start as soon as you begin taking opioid medications or it may develop slowly over time. It’s estimated that up to 4%–5% of the population in the United States regularly takes opioid drugs, and 40%–80% of them experience opioid-induced constipation.

While there is no way to test yourself for opioid-induced constipation, it is helpful to be aware of the signs and symptoms. Common symptoms of opioid-induced constipation include:

  • Infrequent bowel movements
  • Hard, dry bowel movements
  • Pain or straining when toileting 
  • Bloating
  • Nausea
  • Vomiting
  • Abdominal pain or discomfort
  • Gastroesophageal reflux disease (GERD, backing up of stomach acid into the food tube)
  • Diarrhea (loose, watery stools)

Physical Examination

If you have developed any of the common symptoms of opioid-induced constipation, it’s time to see your doctor. Opioid-induced constipation is a relatively common problem and should be considered as a diagnosis anytime an individual takes opioid drugs. 

The first step to making a diagnosis is taking a thorough medical history. Healthcare providers will likely ask you about the frequency and consistency of your bowel movements. They will also ask if you have experienced pain or straining when having a bowel movement. 

Rome IV Criteria

According to the American Gastroenterological Association (AGA), opioid-induced constipation can be diagnosed using the Rome IV definition. The Rome Foundation is a nonprofit organization that develops diagnostic criteria for gut disorders.

According to the Rome Foundation, you meet the criteria for opioid-induced constipation when you experience new or worsening constipation symptoms when starting or increasing opioid therapy and you:

  • Strain during more than 25% of time spent passing stool
  • Have hard or lumpy stools more than 25% of the time
  • Feel as though you are unable to fully empty all of the stool 25% of the time
  • Notice the feeling of a blockage when trying to have a stool
  • Require manual maneuvers to pass stool 25% of the time
  • Have fewer than three bowel movements per week

During the physical exam, your physician will most likely palpate (examine by touch) your abdomen to feel for bloating or a backup of stool. If your physician is concerned that there is a problem with your anal sphincter, the muscles at the end of your rectum that control the release of stools, they may recommend a digital rectal exam (inserting a gloved finger to feel for abnormalities) as well. 

Labs and Tests

Opioid-induced constipation is usually diagnosed with a history and physical. However, your physician may recommend lab tests to determine if there are any other possible causes of your symptoms. Blood tests to expect include:

  • Complete blood count (CBC): A CBC can detect signs of infection or anemia.
  • Electrolyte panel: An electrolyte panel can help determine if you are experiencing electrolyte abnormalities or imbalances.
  • Liver function tests: These can detect changes in liver function. Poor liver function can cause bowel issues such as constipation, bloating, pain, gas, and more.
  • Albumin test: Albumin is the main protein in blood plasma. Low levels of albumin (hypoalbuminemia) can indicate malnutrition and other health concerns.


It is uncommon to require an imaging study for the diagnosis of opioid-induced constipation. If your physician is concerned that there could be another underlying cause for your constipation, they may recommend further testing. 

If your healthcare provider believes that an imaging study is necessary, you might expect one of the following:

  • Abdominal X-ray: Uses X-ray to examine the small intestine for blockages 
  • Abdominal computed tomography (CT) scan: Uses X-ray technology to examine your intestines to look for blockages or other issues
  • Magnetic resonance imaging (MRI) defecography: Uses magnetic waves to examine your rectum, sphincter, and pelvic floor
  • Colonoscopy: Uses a scope to view the inside of the colon to look for polyps and test for colon cancer

Differential Diagnosis

Constipation is a very common condition that affects most of us at some point or another. Common causes of occasional or chronic constipation include:

  • Irritable bowel syndrome (IBS): IBS is a common chronic condition that affects the large intestine and causes constipation and diarrhea 
  • Diabetes: Diabetes (affects how your body turns food into energy) may damage the nerves in the gastrointestinal tract and lead to constipation
  • Hypothyroidism: Hypothyroidism (underactive thyroid) causes processes in the body to slow down, including gastric motility (process of food passing through the digestive system), and leads to constipation.
  • Celiac disease: Most people with celiac disease (intolerance to gluten found in some grains) experience diarrhea, but it’s estimated that up to 10% of people with celiac disease present with constipation. 
  • Colon cancer: Colon cancer can cause both diarrhea and constipation. 

Barriers to Diagnosis 

Opioid-induced constipation is a relatively common problem but still goes undiagnosed too often. A 2019 study found that barriers to diagnosis include:

  • Physicians’ lack of awareness of the problem
  • Patients feeling embarrassed about bringing it up
  • Doctors feeling uncomfortable about asking about constipation
  • Lack of universal diagnostic guidelines
  • Lack of specific treatment plans


Opioid-induced constipation is caused by the physiological changes that take place in the gastrointestinal tract from taking opioid medications. It is a relatively common condition and is usually diagnosed with a thorough medical history and possibly a physical exam as well.

Other diagnostic tools that may be used include blood tests, abdominal X-ray, abdominal CT scan, MRI, and colonoscopy. Other common causes of constipation include IBS, diabetes, hypothyroidism, celiac disease, and colon cancer. 

A Word From Verywell

If you have recently started taking a new opioid drug and are now experiencing constipation symptoms, you likely have opioid-induced constipation. Talk with your healthcare provider right away because this condition is treatable. Know that there are laxative medications that can relieve your symptoms and make passing stool easier and more comfortable. 

Frequently Asked Questions

  • How do I know if I have opioid-induced constipation?

    Common symptoms of opioid-induced constipation include infrequent bowel movements, hard and dry bowel movements, straining, and pain with toileting. These symptoms may start when you begin taking opioids, or they may develop slowly over time. 

  • How do you treat opioid-induced constipation?

    Opioid-induced constipation is usually treated with laxative medications. Talk to your healthcare provider as soon as you develop symptoms to begin treatment and prevent complications. 

  • How do I prevent opioid-induced constipation?

    Because opioids cause changes in the gastrointestinal tract, it is difficult to completely prevent opioid-induced constipation. The best way to minimize side effects is to talk with your healthcare provider about starting a laxative medication when you begin taking opioid medications. 

7 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  5. Cleveland Clinic. Constipation; Symptoms, causes, treatment & prevention. Updated November 7, 2019.

  6. MedlinePlus. Irritable bowel syndrome. Updated July 8, 2021. 

  7. Mesía R, Virizuela Echaburu JA, Gómez J, Sauri T, Serrano G, Pujol E. Opioid-Induced Constipation in Oncological Patients: New Strategies of Management. Curr Treat Options Oncol. 2019 Dec 19;20(12):91. doi:10.1007/s11864-019-0686-6

By Carrie Madormo, RN, MPH
Carrie Madormo, RN, MPH, is a health writer with over a decade of experience working as a registered nurse. She has practiced in a variety of settings including pediatrics, oncology, chronic pain, and public health.