Skin Health Acne Treatment Treating Acne With Oral Erythromycin By Angela Palmer facebook Angela Palmer is a licensed esthetician specializing in acne treatment. Learn about our editorial process Angela Palmer Medically reviewed by Medically reviewed by Casey Gallagher, MD on November 03, 2019 Casey Gallagher, MD, is board-certified in dermatology and works as a practicing dermatologist and clinical professor. Learn about our Medical Review Board Casey Gallagher, MD Updated on August 24, 2020 Print Table of Contents View All Overview Side Effects Other Antibiotics for Acne Antibiotic Resistance Robimycin (oral erythromycin) is an antibiotic used to treat moderate to severe inflammatory acne or acne that isn’t getting better with other treatments. Erythromycin is also used topically to treat acne. Besides acne, erythromycin is used to treat a wide variety of conditions, from ear infections to rosacea. It’s a prescription medication and there is no over-the-counter alternative. LightFieldStudios / Getty Images How It Works Erythromycin works to improve acne by reducing the amount of acne-causing bacteria, called Propionibacteria acnes, on the skin. These bacteria, also called P. acnes, are normally found on most people's skin. But, for those with acne, the bacteria irritate the pore and contributes to redness and inflammation. Erythromycin can help reduce bacteria and also lessen inflammation and redness. Oral erythromycin is not really meant to be used as a long-term acne treatment, though. Ideally, you'll take it for only a few months or just until your acne starts to get better. Then you'll stop using the erythromycin and continue acne treatment with another medication that's better suited to long-term use, like topical combination acne medications, oral contraceptives (for women), or topical retinoids. Think of oral erythromycin as a jump start to get acne and inflammation under control. Possible Side Effects All acne medications have them, and oral erythromycin is no different. Your dermatologist will tell you all about possible side effects before you start your treatment, but these are the most common: Upset stomachNausea and vomitingDiarrheaVaginal yeast infections or oral thrush Is erythromycin upsetting your stomach? Taking it with food can help. If you develop severe stomach pain or severe diarrhea, let your doctor know right away. Oral antibiotics work best when there is a steady amount of the medication in the body. Do your best to take your medication at regular times and try not to skip doses. Make sure you take the entire course of erythromycin prescribed, even if your acne clears up. Tell your dermatologist if your acne isn’t improving at all, or if it gets better for a while but then returns. Not the First Antibiotic Choice for Acne Although erythromycin has been used for years to treat acne, it's not the go-to acne treatment antibiotic that it used to be. Today we have newer antibiotics that are the more popular choice. And, compared to these other options, erythromycin simply isn't the most effective antibiotic treatment for acne. Some of the oral antibiotics that are used more often to treat acne today are: Sumycin (tetracycline)Azithromycin (zithromax)Vibramycin (doxycycline)Minoz (minocycline)Cleocin HCl (clindamycin) Erythromycin is still the best antibiotic acne treatment option for pregnant or breastfeeding moms, though. It also can be used by younger children because, unlike some of the other oral antibiotics, it won’t cause tooth discoloration. Antibiotic Resistance and Oral Erythromycin You’ve probably heard about the growing problem of bacterial resistance caused by the overuse of antibiotics. Because of this, some people find their acne doesn’t respond well to erythromycin treatment. To help combat antibiotic resistance, oral erythromycin shouldn't be the only treatment you're using to clear your acne. It will work best if it's combined with another acne treatment medication. That means you'll probably be using several different acne treatment medications at once. Your dermatologist will most likely prescribe a topical acne medication to use while you're taking oral erythromycin. Oral erythromycin fights bacteria. But bacteria is only one acne-causing factor. Other factors that contribute to breakouts are blocked pores and excess oil. Using medications that fight these factors, for example topical retinoids and benzoyl peroxide, will help you get better results than using oral erythromycin alone. A Word From Verywell Oral erythromycin isn't the first, nor necessarily the best, treatment choice for acne. Oral erythromycin should only be prescribed in very specific cases, where an oral antibiotic is needed and other antibiotics aren't an option. Oral erythromycin isn't the go-to acne treatment choice but, in certain cases, it can be helpful in getting acne under control. Ideally, oral antibiotics should be used for the shortest amount of time possible to get acne under control. They should also be used along with another, ideally a topical, acne treatment. You can do your part to fight antibiotic-resistant bacteria by taking all of the prescribed antibiotic, not skipping doses, and following usage directions as closely as possible. Was this page helpful? Thanks for your feedback! Dealing with acne can be frustrating. Our free guide provides expert tips to help you take control. Sign up and get yours today. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Whitney KM, Ditre CM. Management strategies for acne vulgaris. Clin Cosmet Investig Dermatol. 2011;4:41-53. doi:10.2147/CCID.S10817 Pugashetti R, Shinkai K. Treatment of acne vulgaris in pregnant patients. Dermatol Ther. 2013;26(4):302-11. doi:10.1111/dth.12077 Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945-73.e33. doi:10.1016/j.jaad.2015.12.037 Additional Reading Dreno B, Thiboutot D, Gollnick H, Bettoli V, et. al. Antibiotic Stewardship in Dermatology: Limiting Antibiotic Use in Acne. European Journal of Dermatology. 2014 May-Jun;24(3):330-4. Pugashetti R, Shinkai K. Treatment of Acne Vulgaris in Pregnant Patients. Dermatologic Therapy. 2013 Jul-Aug; 26(4):302-11. Whitney KM, Ditre CM. Management Strategies for Acne Vulgaris. Clinical, Cosmetic, and Investigational Dermatology. 2011;4:41-53. Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945-73.e33. doi:10.1016/j.jaad.2015.12.037