Oxistat (Oxiconazole) - Topical

What Is Oxistat?

Oxistat (oxiconazole) is a topical medicine used to treat skin fungal infections in people 12 years and older. It belongs to the drug class called imidazole derivatives. 

Oxiconazole works by stopping the growth of fungus. It is available as a lotion and cream. It contains benzoic acid, cetyl alcohol, and propylene glycol.

Drug Facts

Generic Name: Oxiconazole

Brand Name(s): Oxistat

Drug Availability: Prescription

Therapeutic Classification: Imidazole derivatives

Available Generically: Yes

Controlled Substance: N/A

Administration Route: Topical

Active Ingredient: Oxiconazole

Dosage Form(s): Lotion, cream

What Is Oxistat Used For?

Oxistat is a topical antifungal used to treat several skin fungal infections in adults and children over 12 years old. It treats:

These conditions are frequently caused by specific organisms called dermatophytes, especially in high humidity and temperatures.

How to Use Oxistat

Apply a thin layer of oxiconazole to clean, dry, affected skin. Gently rub it in. Be sure to wash your hands before and after applying this medicine to your skin. If your hand is in the treated area, do not wash it after application. 

Do not apply it to your nose, eyes, vagina, or mouth. Avoid occlusive dressings or bandages except if your healthcare provider tells you to. 

If using the lotion, shake well before use.


Store oxiconazole at room temperature (59 F to 86 F) in a dry place. Do not store it in a bathroom.

Keep your medications out of the reach of children and pets, ideally locked in a cabinet or closet.

If you plan to travel with Oxistat, get familiar with your final destination's regulations. In general, be sure to make a copy of your Oxistat prescription. If possible, keep your medication in its original container from your pharmacy with your name on the label. Ask your pharmacist or healthcare provider if you have any questions about traveling with your medicine.

Discard all unused and expired drugs, but do not throw them down the drain or toilet. Ask your pharmacist or healthcare provider about the best ways to dispose of this medicine. And check out drug take-back programs in your area.

How Long Does Oxistat Take to Work?

Oxistat may begin to work as soon as you apply it. The exact time it takes Oxistat to work is unknown. Its onset may vary from person to person. Be sure to check with your healthcare provider or pharmacist for any questions.

What Are the Side Effects of Oxistat?

This is not a complete list of side effects, and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your pharmacist or healthcare provider. You may report side effects to the Food and Drug Administration (FDA) at fda.gov/medwatch or 800-FDA-1088.

Common Side Effects

Some people may experience side effects with Oxistat. The most common side effect of Oxistat is irritation where this drug is used. Stop using if skin irritation or sensitivity happens.

Severe Side Effects

Oxistat can cause many side effects. Some may be life-threatening. Call your healthcare provider promptly if you have serious side effects. Likewise, call 911 if you think you have a medical emergency. Severe side effects include:

  • Burning
  • Swelling
  • Blistering
  • Oozing or bleeding
  • Signs of an allergic reaction, like throat tightness

Report Side Effects

Oxistat may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your provider may send a report to the FDA MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Oxistat Should I Use?

Drug Content Provided and Reviewed by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For cream or lotion dosage form:
    • For ringworm of the body or groin:
      • Adults and children—Use 1 or 2 times a day for at least 2 weeks.
    • For athlete's foot:
      • Adults and children—Use 1 or 2 times a day for at least 4 weeks.
    • For ringworm of the trunk:
      • Adults and children—Use once a day for at least 2 weeks.


The following modifications should be kept in mind when using Oxistat:

Pregnancy: Animal studies show that Oxistat may not be harmful to your fetus. Nevertheless, discuss with your healthcare provider if you are or plan to become pregnant, and weigh the benefits and risks of taking Oxistat during your pregnancy.

Breastfeeding: Although its systemic absorption may be low, oxiconazole may be found in breast milk. Talk with your healthcare provider if you plan to breastfeed, to weigh the benefits and risks of taking Oxistat while nursing and the different ways available to feed your baby.

Adults over 65: Oxistat works similarly in people over the age of 65 as it does in younger people. There is no adjustment in dosing required for this medicine in this population.

Children: This medicine has not been approved for children under 12 years old.

Missed Dose

If you forget to apply this medicine, put on the missed dose once you remember. If it is close to your next application time, skip the missed dose and return to your regular time. Do not use more than one application or use extra doses.

Try to find ways to help yourself remember to routinely use your medication. If you miss too many doses, Oxistat might become less effective.

Overdose: What Happens If I Use Too Much Oxistat?

There has been no report of Oxistat overdose in humans.

If you think you're experiencing an overdose or life-threatening symptoms, seek immediate medical attention.

What Happens If I Overdose on Oxistat?

If you think you or someone else may have overdosed on Oxistat, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Oxistat, call 911 immediately.


Drug Content Provided and Reviewed by IBM Micromedex®

If your skin problem does not improve within 2 to 4 weeks, or if it becomes worse, check with your doctor.

To help clear up your infection completely and to help make sure it does not return, good health habits are also required. The following measures will help reduce chafing and irritation and will also help keep the area cool and dry.

  • For patient using oxiconazole for ringworm of the groin:
    • Avoid wearing underwear that is tight-fitting or made from synthetic materials (for example, rayon or nylon). Instead, wear loose-fitting, cotton underwear.
    • Use a bland, absorbent powder (for example, talcum powder) or an antifungal powder on the skin. It is best to use the powder between the times you use oxiconazole.
  • For patients using oxiconazole for ringworm of the foot:
    • Carefully dry the feet, especially between the toes, after bathing.
    • Avoid wearing socks made from wool or synthetic materials (for example, rayon or nylon). Instead, wear clean, cotton socks and change them daily or more often if the feet sweat a lot.
    • Wear sandals or other well-ventilated shoes.
    • Use a bland, absorbent powder (for example, talcum powder) or an antifungal powder between the toes, on the feet, and in socks and shoes 1 or 2 times a day. It is best to use the powder between the times you use oxiconazole.

If you have any questions about these measures, check with your health care professional.

What Are Reasons I Shouldn’t Use Oxistat?

Avoid taking Oxistat if you are hypersensitive to oxiconazole or any part of its formulation. Also, do not use this medicine if you have an azole antifungal allergy.

Ask your pharmacist or healthcare provider for a full list of the ingredients if you're unsure.

What Other Medications Interact With Oxistat?

There are no known significant interactions between Oxistat and any medicine. However, talk with your healthcare provider about any medications you take or plan to take, including over-the-counter (OTC), nonprescription products, vitamins, herbs, or plant-based medicines.

What Medications Are Similar?

Other drugs similar to oxiconazole that are antifungal (topical) drugs include:

  • Gyne-Lotrimin (clotrimazole)
  • Zolpak (econazole)
  • Nizoral A-D (ketoconazole)
  • Lotrimin AF (miconazole)
  • Ertaczo (sertaconazole)
  • Exelderm (sulconazole)
  • Monistat 1-Day (tioconazole)

This list lists drugs also used to treat skin fungal infections. It is NOT a list of medicines suggested to take with Oxistat. Ask your healthcare provider if you have questions.

Frequently Asked Questions

  • What is Oxistat used to treat?

    Oxistat is used to treat fungal skin infections in adults and children over 12 years old.

  • What are the common side effects of Oxistat?

    The most common side effects of Oxistat are:

    • Skin irritation 
    • Skin sensitivity
  • Where should I store Oxistat?

    Store oxiconazole at room temperature in a dry place.

  • What should I do if I miss a dose of Oxistat?

    Apply the missed dose as soon as you think of it. Skip the missed dose if it is too close to the next dose. Return to your regular application schedule. Do not apply extra doses or double the amount used.

How Can I Stay Healthy While Using Oxistat?

Skin fungal infections do not clear overnight. So, be patient while using this medicine. If you start noticing skin irritations or sensitivity, stop using it and contact your healthcare provider. 

On the other hand, if your symptoms begin to clear, do not stop using this medicine. Instead, continue using it as directed and for the duration prescribed.

Note that fungus loves damp areas. Hence, always keep the affected areas clean and dry.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

2 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Food and Drug Administration. Oxistat label

  2. DailyMed. Repatha - evolocumab injection, solution.

By Queen Buyalos, PharmD
Queen Buyalos is a pharmacist and freelance medical writer. She takes pride in advocating for cancer prevention, overall health, and mental health education. Queen enjoys counseling and educating patients about drug therapy and translating complex ideas into simple language.