What to Know About PainBloc24

Topical Pain Reliever

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PainBloc24 is an over-the-counter topical pain reliever that can be used for minor aches and pains associated with arthritis, muscle strains, backache, bruises, and sprains. Studies have shown the ingredients in PainBloc24 are highly effective at reducing pain. It uses the highest concentration of capsaicin allowed by the FDA without a prescription.

Different preparations of PainBloc24 include a roll-on, pain pen, and flexible tape. You may feel the pain-relieving effects of PainBloc24 within a few hours of your first use, however, pain relief builds with daily use.

PainBloc24 reaches its full effect at relieving pain from arthritis or muscle pain after several days. The effects of the topical continue to build over time. If you apply PainBloc for seven days as directed, you can experience its full pain blocking abilities for up to a month.

Woman Using Laptop Holds Wrist in Pain

Grace Cary / Moment / Getty Images


PainBloc24 is used to relieve pain from arthritis and other minor aches and pains of the muscles and joints. PainBloc24 contains 0.25% capsaicin, which is administered topically using PainBloc’s own Neuromax technology that helps the capsaicin more effectively penetrate the skin.

Capsaicin is a powerful ingredient that has been shown clinically to reduce pain by deactivating certain never fibers that transmit pain signals. Repeated use of capsaicin causes analgesia, or pain relief, through the desensitization of nerve fibers.

In a clinical study using capsaicin on osteoarthritis knee pain, over half the patients who applied capsaicin daily experienced a 50% reduction in pain. After seven days, the full pain-blocking power of PainBloc24 takes effect, which can provide 24-hour relief for the remainder of the month.

One preparation of PainBloc24, the Flexi-Stretch Pain Tape, does not use capsaicin but instead uses lidocaine, a topical local anesthetic. It numbs the area, blocking nerve pain signals.


PainBloc24 comes in different preparations, which vary in ingredients and how they are applied. When choosing which PainBloc24 product is best for you, consider the location of the affected area. The Roll-On applicator is best for larger areas of the body such as back, knees, elbows, even large areas of the hands and wrists.

For smaller areas like fingers and finger joints, the Pain Pen can help you more accurately reach each area. The smaller applicator allows for more targeted application.

For more immediate relief while exercising or remaining active you might choose the Flexi-Stretch Pain Tape. Please note that the Flexi-Stretch version does not contain capsaicin so the building effects of pain relief may not be the same.


The PainBloc24 Roll-on comes in a 0.5 fluid ounce bottle with a roller applicator.

Active Ingredient:

  • Capsaicin 0.25%

Inactive Ingredients:

  • Alcohol
  • Diethylene glycol monoethyl ether
  • Hyaluronate sodium
  • Polysorbate 80
  • Propylene glycol
  • Water

Pain Pen

The PainBloc24 Pain Pen is a 0.39 fl oz pen with a small applicator to provide precise targeted application.

Active ingredient:

  • Capsaicin 0.25%

Inactive Ingredients:

  • Alcohol
  • Diethylene glycol monoethyl ether
  • Hyaluronate sodium
  • Polysorbate 80
  • Pramoxine HCl
  • Propylene glycol
  • Water

Flexi-Stretch Pain Tape

The PainBloc24 Flexi-stretch Pain Tape comes in a pack of ten 2-inch by 5 1/2-inch patches that can be applied on moving joints to provide pain relief even while exercising.

Active Ingredients:

  • Lidocaine 4%

Inactive Ingredients:

  • Acrylic adhesive
  • Aloe barbadensis (aloe vera) leaf juice
  • Arnica montana flower extract
  • Boswellia
  • Calendula
  • Lavender
  • Methylsulfonylmethane (MSM)
  • Polysorbate 80
  • Potassium sorbate
  • Sodium benzoate
  • Tocopheryl acetate (Vitamin E)
  • Water
  • White curcumin

How To Use

Each product has specific use instructions.

PainBloc24 Roll-On and Pain Pen

These should be applied daily, every 12 to 24 hours. Do not use more than twice a day. Apply a single layer to the affected area using single strokes. A little goes a long way, so there is no need to double apply.

After applying the PainBloc24 Roll-On or Pain Pen make sure to wash your hands immediately. If you are applying to the hands, wait 30 minutes before washing.

Avoid touching areas that may be sensitive such as the eyes, nose, and mucous membranes. If soap does not remove all of the product, you can try using skin oil or mineral oil.

Flexi-Stretch Pain Tape

Flexi-Stretch Pain Tape can be used for up to 12 hours at a time. Use no more than three strips at a time, no more than twice a day.

To apply the Flexi-stretch Pain Tape, clean and dry the affected area. You may need to trim or remove excess hair for better adhesion. Tear off a strip from the roll, remove the backing, and apply it to the skin.

Do not bandage tightly. Avoid contact with eyes and mucous membranes.

Potential Side Effects

When first applying PainBloc24 you may experience a mild to moderate burning sensation. This is usually a sign that the product is working and the nerve fibers that carry sensations of pain are being desensitized. You may also experience mild redness.

These side effects usually diminish with daily use and are not reasons to discontinue using PainBloc24. However, if severe redness, itching, burning, stinging, or irritation persists, spreads, or becomes tender. discontinue use and contact your healthcare provider.

Warnings and Precautions

If you have never used PainBloc24, or you have sensitive skin, it is recommended you test the product on a small area before applying as directed. The active ingredient in PainBloc24 is capsaicin which is derived from chili peppers.

You may feel a warming or burning sensation upon application. This is an indication that the product is working and these sensations will diminish with daily use. To mitigate discomfort you can apply ice or a cold compress to the site of application.

Warm or hot water, exercise, sun exposure, and heat may increase the warming or burning sensations from the capsaicin. Do not apply immediately before or after exercise, swimming, bathing, or spending time in the sun.

Stop Using and Call Your Healthcare Provider

Call your healthcare provider if you note these symptoms:

  • Your condition worsens or you experience difficulty breathing or swallowing
  • Redness or irritation develops with the pain tape
  • Redness persists, spreads, or becomes tender or a severe burning sensation occurs with the Roll-On or Pain Pen
  • You experience localized skin reactions such as rash, itching, pain, swelling, or blistering with the Pain Tape
  • Symptoms last more than seven days or clear up and occur again within a few days


2 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Peppin JF, Pappagallo M. Capsaicinoids in the treatment of neuropathic pain: a reviewTher Adv Neurol Disord. 2014;7(1):22-32. doi:10.1177/1756285613501576

  2. National Institutes of Health ClinicalTrials.gov. Osteoarthritis knee pain relief study of 0.25% 920-CGS-200 - study results.

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