What Is Pomegranate Juice?

This tangy beverage has been studied for heart health and more

Pomegranate juice has become a popular drink, in large part due to much-trumpeted health claims. Pomegranates are the fruit of the Punica granatum tree. The fruit itself is bitter, so only the seeds are eaten. One pomegranate has nearly 30 milligrams (mg) of vitamin C, about 40% of the daily recommendation.

Pomegranate has been studied for its effects on lowering inflammation, improving heart health, and more. Research supports some health claims but has also found some safety concerns.

This article reviews research on pomegranate juice's uses, benefits, side effects, and interactions.

Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. When possible, choose a supplement tested by a trusted third party, such as USP, ConsumerLabs, or NSF.

However, even if supplements are third-party tested, that doesn’t mean they are safe for all or effective in general. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications.

Supplement Facts

  • Active ingredient(s): α (alpha) and β (beta) punicalagin
  • Alternate name(s): Punica granatum L.
  • Legal status: Food, over-the-counter (OTC) herbal supplement (United States)
  • Suggested dose: 100 to 500 milliliters (mL) of juice
  • Safety considerations: Pregnant or breastfeeding people should ask their healthcare provider whether pomegranate juice is safe.
A whole pomegranate, a cut-up pomegranate, and a glass of pomegranate juice.

Burcu Atalay Tankut / Getty Images

Uses of Pomegranate Juice

Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. No supplement is intended to treat, cure, or prevent disease.

Much of the research on pomegranate and pomegranate juice is preliminary. Studied conditions included:

  • Heart health
  • Inflammation
  • Infection
  • Dental plaque

Heart Health

A review of research says pomegranate juice may lower blood pressure and improve high blood pressure (hypertension) risk factors.

A recent randomized controlled trial similarly demonstrated that eight-week pomegranate juice consumption showed beneficial effects on blood pressure.

Other research suggested pomegranate juice had an impact on the following heart health indications:

It's important to note that most studies have not been done on humans, so it's challenging to say what benefits there are without further human studies. More research is needed to confirm pomegranate juice's benefits.


A review of studies suggests pomegranate may help fight chronic inflammation. It may have use in conditions like inflammatory bowel disease (IBD) and rheumatoid arthritis (RA).  

A more recent meta-analysis and systematic review also revealed the potential of pomegranate products to fight inflammation.

However, more extensive and better-designed trials are needed.


Inflammation is part of the immune response to infection. Studies suggest pomegranate juice may help ward off infections. In one study, people undergoing dialysis had fewer hospitalizations for infections and fewer signs of inflammation. More research is needed to confirm these claims.

Dental Plaque

Limited evidence suggests pomegranate juice may help control dental plaque.

In a small study, 30 people used either a pomegranate dental rinse, an antiseptic dental rinse, or water. Researchers found the pomegranate solution performed just as well as the antiseptic solution. It had no adverse side effects.

It also appeared to inhibit the growth of germs that contribute to periodontitis (an inflammatory gum disease).

Other Uses

Research is ongoing into other health effects of pomegranate, including:

More research is needed to determine whether pomegranate is safe and effective for these conditions.

What Are the Side Effects of Pomegranate Juice?

Pomegranate juice consumed in moderate amounts is most likely safe for most people. But certain people should exercise caution.

It's possible to be allergic to pomegranate, which can cause:

  • Itching
  • Swelling
  • Runny nose
  • Difficulty breathing
  • Anaphylaxis (a life-threatening reaction)

If you have oral allergy syndrome, you may be sensitive to pomegranate. This condition involves allergies to birch pollen and many fruits.

Some people have digestive side effects from pomegranate, such as diarrhea, which is the most common. Pomegranate root, stem, and peel contain substances that may be harmful in large amounts.

Pomegranate juice may also interact negatively with some medications.

Common Side Effects

Diarrhea is the most common side effect of pomegranate juice.

Severe Side Effects

Animal studies and human clinical trials have noted no severe side effects, including toxicity. However, pomegranate root, stem, and peel contain substances that may be harmful in large amounts.


If you have oral allergy syndrome, you may be sensitive to pomegranate. This condition involves allergies to birch pollen and many fruits.

If you're pregnant or breastfeeding, ask your healthcare provider if pomegranate juice is safe.

Dosage: How Much Pomegranate Juice Should I Take?

Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your needs.

Pomegranate is available in many forms, including:

  • Pills
  • Tablets
  • Capsules
  • Softgels
  • Granules
  • Powder
  • Liquid
  • Paste

Labels often suggest a daily dose of eight ounces for adults. As a general rule, never take more than the recommended dose. Check with your child's pediatrician for suggestions on juice consumption for different age groups.

What Happens If I Take Too Much Pomegranate Juice?

Animal studies and human clinical trials have investigated the toxicity of pomegranate, and no adverse side effects have been noted. Pomegranate is safe at high doses in adults. However, this may be different for children.


Some early evidence suggests combining pomegranate with statins (cholesterol-lowering drugs) is dangerous. Statins include but are not limited to the following:

The combination of pomegranate and statins may cause rhabdomyolysis, a serious condition involving the breakdown of muscle fibers and possibly kidney failure. This may be due to pomegranates blocking an enzyme in the intestines, allowing you to absorb more medication. Grapefruit juice is better known for this effect, and many medication labels warn against drinking it.

Pomegranate juice may interact with other medications, such as:

It is essential to carefully read a supplement's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Review any supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications.

How to Store Pomegranate Juice

You'll find pomegranate juice at most grocery stores. It may be in the juice aisle or alongside whole fruit.

Organic juice may help you avoid harmful chemicals. Check the label to see if other juices or sweeteners are added.

Consider whether you want pasteurized juice. Pasteurization kills harmful bacteria, but it may also kill other compounds in the juice.

Some people choose to make their own fresh pomegranate juice. To do this, liquify pomegranate seeds in a blender. Then strain the juice to remove any unwanted roughage.

Similar Supplements

Grapefruit juice may have similar properties as pomegranate juice.

Grapefruit has been found to have antimicrobial, antiparasitic, insecticidal, antioxidant, and cardiovascular effects. Like pomegranate juice, it contains numerous bioactive compounds.

Frequently Asked Questions

  • What should I look for when buying a whole pomegranate?

    You'll find the best pomegranates when the fruit is in season, from late summer to early winter. Here are some other tips for buying whole pomegranates:

    • A ripe pomegranate should feel heavy.
    • The skin should be bright or deep red and feel firm and leathery.
    • Browning means it's likely past its prime.
    • Abrasions on the skin don't affect its quality.
  • What is the best way to store a whole pomegranate?

    You can keep a pomegranate at room temperature for a week or two. Refrigeration can keep it fresh for up to three months. Keep it whole until you're ready to eat it. If you remove the seeds, keep them in the refrigerator.

  • Does pomegranate juice interact with any medications?

    Pomegranate juice may interact with the following drugs:

Sources of Pomegranate Juice & What To Look For

Pomegranate juice may be consumed from the fruit's seeds. Pomegranate seed oil is also frequently consumed and may contain other parts of the fruit.

Food Sources of Pomegranate Juice

Pomegranate may be consumed in its whole form. The seeds may be eaten from the fruit in their natural form.

Pomegranate Supplements

Pomegranate is available in many forms, including:

  • Pills
  • Tablets
  • Capsules
  • Softgels
  • Granules
  • Powder
  • Liquid
  • Paste


Some early evidence suggests pomegranate juice may improve heart health, fight inflammation and infection, and prevent dental plaque. However, more research is needed to confirm these benefits.

Ask your healthcare provider if pomegranate juice is safe for you. It may cause side effects, like diarrhea, allergies, or adverse drug interactions in some people.

29 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. U.S. Department of Agriculture. FoodData Central. Pomegranates, raw.

  2. Moazzen H., Alizadeh M. Effects of pomegranate juice on cardiovascular risk factors in patients with metabolic syndrome: a double-blinded, randomized crossover controlled trial. Plant Foods Hum Nutr. 2017;72(2):126-133. doi:10.1007/s11130-017-0605-6

  3. Esposto S, Veneziani G, Taticchi A, et al. Chemical composition, antioxidant activity, and sensory characterization of commercial pomegranate juices. Antioxidants (Basel). 2021;10(9):1381. doi:10.3390/antiox10091381

  4. Wang P, Zhang Q, Hou H, et al. The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: a meta-analysis and systematic review. Complement Ther Med. 2020;49:102358. doi:10.1016/j.ctim.2020.102358

  5. Zarfeshany A, Asgary S, Javanmard SH. Potent health effects of pomegranateAdv Biomed Res. 2014;3:100. doi:10.4103/2277-9175.129371

  6. Zarfeshany A, Asgary S, Javanmard SH. Potent health effects of pomegranateAdv Biomed Res. 2014;3:100. doi:10.4103/2277-9175.129371

  7. Barati Boldaji R, Akhlaghi M, Sagheb MM, et al. Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial. J Sci Food Agric. 2020;100(2):846-854. doi:10.1002/jsfa.10096

  8. Sahebkar A, Ferri C, Giorgini P, et al. Effects of pomegranate juice on blood pressure: a systematic review and meta-analysis of randomized controlled trialsPharmacol Res. 2017;115:149-161. doi:10.1016/j.phrs.2016.11.018

  9. Taheri Rouhi SZ, Sarker MMR, Rahmat A, et al. The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of langerhans in streptozotocin-nicotinamide induced type 2 diabetic sprague-dawley rats. BMC Complementary and Alternative Medicine. 2017;17(1):156. doi:10.1186/s12906-017-1667-6

  10. Stowe CB. The effects of pomegranate juice consumption on blood pressure and cardiovascular healthComplementary Therapies in Clinical Practice. 2011;17(2):113-115. doi:10.1016/j.ctcp.2010.09.004

  11. Wang D, Özen C, Abu-Reidah IM, et al. Vasculoprotective effects of pomegranate (Punica granatum L.)Front Pharmacol. 2018;9:544. doi:10.3389/fphar.2018.00544

  12. National Institutes of Health, National Center for Complementary and Integrative Health. Pomegranate.

  13. Danesi F, Ferguson LR. Could pomegranate juice help in the control of inflammatory diseases? Nutrients. 2017;9(9):958. doi:10.3390/nu9090958

  14. Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J Ethnopharmacology. 2012;143(2):397-3405. doi:10.1016/j.jep.2012.07.004

  15. Bhadbhade SJ, Acharya AB, Rodrigues SV, et al. The antiplaque efficacy of pomegranate mouthrinseQuintessence International. 2011;42(1):29-36.

  16. Bassiri-Jahromi S. Punica granatum (pomegranate) activity in health promotion and cancer preventionOncol Rev. 2018;12(1):345. doi:10.4081/oncol.2018.345

  17. Banihani S, Swedan S, Alguraan Z. Pomegranate and type 2 diabetesNutrition Research. 2013;33(5):341-348. doi:10.1016/j.nutres.2013.03.003

  18. Eghbali S, Askari SF, Avan R, et al. Therapeutic effects of Punica granatum (pomegranate): an updated review of clinical trialsJ Nutr Metab. 2021;2021:5297162. doi:10.1155/2021/5297162

  19. Alshinnawy AS, El-Sayed WM, Taha AM, et al. Astragalus membranaceus and punica granatum alleviate infertility and kidney dysfunction induced by aging in male ratsTurk J Biol. 2020;44(4):166-175. doi:10.3906/biy-2001-5

  20. Özer M, Severcan EU, Cetin S, et al. Pomegranates as a rare cause of anaphylaxis in a school child. Revue Française d’Allergologie. 2022;62(6):582-584. doi:10.1016/j.reval.2021.11.005

  21. Kim JH, Kim SH, Park HW, et al. Oral allergy syndrome in birch pollen-sensitized patients from a korean university hospitalJournal of Korean Medical Science. 2018;33(33). doi:10.3346/jkms.2018.33.e218

  22. Viladomiu M, Hontecillas R, Lu P, et al. Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents. Evid Based Complement Alternat Med. 2013;2013:789764. doi:10.1155/2013/789764

  23. Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in ratsDrug Metab Dispos. 2005;33(5):644-648. doi:10.1124/dmd.104.002824

  24. Sorokin AV, Duncan B, Panetta R, et al. Rhabdomyolysis associated with pomegranate juice consumptionAm J Cardiol. 2006;98(5):705-706. doi:10.1016/j.amjcard.2006.03.057

  25. Kim H, Yoon YJ, Shon JH, et al. Inhibitory effects of fruit juices on CYP3A activityDrug Metab Dispos. 2006;34(4):521-523. doi:10.1124/dmd.105.007930

  26. U.S. Food and Drug Administration. Grapefruit juice and some drugs don't mix.

  27. Chen M, Zhou SY, Fabriaga E, et al. Food-drug interactions precipitated by fruit juices other than grapefruit juice: an update review. J Food Drug Anal. 2018;26(2S):S61-S71. doi:10.1016/j.jfda.2018.01.009

  28. Cristóbal-Luna JM, Álvarez-González I, Madrigal-Bujaidar E, et al. Grapefruit and its biomedical, antigenotoxic and chemopreventive properties. Food Chem Toxicol. 2018;112:224-234. doi:10.1016/j.fct.2017.12.038

  29. Vučić V, Grabež M, Trchounian A, et al. Composition and potential health benefits of pomegranate: a review. Curr Pharm Des. 2019;25(16):1817-1827. doi:10.2174/1381612825666190708183941

Additional Reading
  • Therapeutic Resource Center, Natural Medicine Database: Professional Monograph. Pomegranate.

By Jinan Banna, PhD, RD
Jinan Banna, PhD, RD is the founder of Jinan Banna LLC and an Associate Professor of Nutrition at the University of Hawaii, where she performs research in obesity prevention. Jinan helps working women to lose weight so that they can feel confident and energetic by offering free information on her blog, as well as nutrition coaching.

Originally written by Cathy Wong
Cathy Wong

Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.

Learn about our editorial process