Popular Supplements for Joint Health

Compare active ingredients and quality assurance

Most people with arthritis or related joint conditions are willing to try just about anything to achieve pain relief. Even those who have a prescribed treatment regimen pay attention to alternatives, including supplements for joint health.

There are several brand name supplements for joint health, as well as generic versions that carry store labels (e.g., CVS, Walgreen's, Target). Some of the supplements are not inexpensive. It's important to compare when shopping for joint supplements. Of course, you will want to compare price and find the best deal. But, you also need to know what's in the product. Compare ingredients and the quantity of the active ingredients. In other words, compare apples with apples. You also need to compare quality and brand reputation. The manufacturer should follow Good Manufacturing Practice (GMP) to ensure the quality of the dietary supplement and to ensure that the supplement is labeled appropriately.


Instaflex (Joint Support)

Instaflex (Joint Support) contains 8 active ingredients: glucosamine sulfate, MSM (methylsulfonylmethane), white willow bark extract, ginger root concentrate, Boswellia serrate extract, turmeric root extract, cayenne, and hyaluronic acid.


Move Free

Move Free is a dietary supplement that contains glucosamine hydrochloride, chondroitin sulfate, hyaluronic acid, and a powerful antioxidant which is derived from two Chinese herbs. There are several formulations of Move Free, with varying amounts of the active ingredients.


Osteo Bi-Flex

Osteo Bi-Flex contains glucosamine and chondroitin. There are several formulations: Regular Strength, Double Strength, Plus MSM, Triple Strength, and Advanced. The Advanced formulation also contains a potent extract of Boswellia serrata called 5-Loxin.


MegaRed Joint Care

MegaRed Joint Care is a dietary supplement that combines omega-3 krill oil, hyaluronic acid, and astaxanthin.



Most joint supplements contain some combination of glucosamine, chondroitin, MSM, SAM-e or hyaluronic acid. SierraSil has none of those. It is an all-natural mineral complex.



Supple is a liquid dietary supplement which contains glucosamine, chondroitin sulfate, 9 vitamins and minerals (vitamins C, D, E, B6, B12, niacin, pantothenic acid, calcium, magnesium), and rebaudioside-A.


Joint Juice

Joint Juice is a liquid dietary supplement. The juice-based supplement contains glucosamine HCl and vitamin C as its primary active ingredients. Joint Juice also has a version with green tea extract and yet another version with water, glucosamine, B vitamins, and electrolytes.


Knox NutraJoint

The main active ingredient in Knox NutraJoint is Gelatine. The product also contains several vitamins and minerals.


The Bottom Line

Remember, the United States Food and Drug Administration classifies dietary supplements as a subcategory of food. While they allow labeling claims that refer to joint strength, joint flexibility and joint health, the FDA has not evaluated the products and no claim can be made with reference to the treatment, cure, or prevention of any disease.

Also, be sure to discuss any supplement you wish to try with your doctor before using the product. Your doctor will be able to advise you about potential benefits or risks, if any exist.


E-Commerce Content is independent of editorial content and we may receive compensation in connection with your purchase of products via links on this page.

Was this page helpful?

Article Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  • Guidance for Industry: Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements; Small Entity Compliance Guide. FDA. December 2010.
  • Joint supplements: Is there hope behind the hype? Peter Pollack. AAOS Now. May 2007