Facial Swelling Caused by Prednisone

Often Called "Moon Face"

Prednisone "moon face" is often thought of as an annoying side effect, though it can certainly impact your quality of life, and is worth addressing. Not everyone experiences all the side effects of prednisone, and some people taking this drug might not experience facial swelling at all.

Corticosteroid drugs such as prednisone are commonly used to treat inflammatory bowel disease (IBD) and many other inflammatory conditions. These drugs are frequently prescribed because they are inexpensive and often work quickly to squelch inflammation.

prednisone and facial swelling.
Lara Antel / Verywell 

Prednisone and most other steroid drugs given intravenously or by mouth have several potential side effects. Some side effects can be quite serious and others are considered more of a nuisance than a threat to health. One side effect that is associated with the long-term use of steroids is the development of a round, or moon-shaped, face.

How Prednisone Causes Facial Swelling

One of the more visible effects of long-term use of high dosages of prednisone is swelling in the cheeks and in the neck. Prednisone might also cause weight gain and redistribution of fat deposits in some people. This leads to fat going to specific areas of the body, including the face, abdomen, and the back of the neck. 

When the fat winds up around the base of the neck and the collarbone it's called "supraclavicular fat pads." Fat on the back of the neck is sometimes referred to as a "buffalo hump." These are the types of prednisone side effects that can certainly lead to a lot of unhappiness in someone who is taking this drug.

The Emotional Toll of Facial Swelling

Facial mooning can be a difficult side effect to deal with for anyone and especially for younger patients (which often includes those with IBD). It is a visible side effect and it changes a person's appearance, sometimes quite drastically.

These changes in the cheeks and the neck often lead to patients feeling unattractive and unhappy at a time when they are already feeling ill. Despite its drastic effect on appearance, this side effect of prednisone is actually not medically dangerous and is considered largely cosmetic.

The good news is that prednisone moon face will go down when the drug is discontinued. Usually, side effects such as moon face start to go away when the dosage is about 10 mg/day.


Prednisone moon face is not a dangerous side effect. The facial roundness will typically decrease once the steroid is tapered down and discontinued.

Side Effects

Some of the side effects of prednisone can best be avoided by minimizing the dose as much as possible with the help of your physician. However, there are some side effects of prednisone that are considered long-lasting and medically dangerous. Any troubling side effects while taking prednisone should be discussed with a physician.

Prednisone side effects

Brianna Gilmarti / Verywell

Importance of Tapering

Because prednisone is a steroid, it affects the body's natural production of cortisol. If the prednisone is stopped too quickly, the body may not be able to adjust, and there could be serious health effects.

Prednisone cannot be stopped suddenly—the dosage must be tapered down. This means that when a physician determines that the dose can be lowered, it's lowered slowly over a period of days or months.

How fast or slow the dosage is lowered depends on how long it has been taken, and how much was taken. Prednisone that is taken for a long time at high doses may need to be lowered very slowly, usually every week or few weeks.


Such drastic changes in a person's appearance because of a drug is upsetting. When people are prescribed prednisone, they're not well, to begin with, and adding on a cosmetic adverse effect doesn't help the situation.

It is crucial for people with IBD to take care of their mental health as well as their physical health. Talk to a gastroenterologist about the potential for the side effects of prednisone, as well as how to avoid them and when they will go away.

If prednisone side effects are causing feelings of sadness or depression, a primary care provider or gastroenterologist can make a recommendation to a mental health professional. Even a few visits with a counselor can go a long way towards improving how people with IBD feel about their disease and their quality of life.

Was this page helpful?
Article Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. American Osteopathic College of Dermatology. Steroids (oral).

  2. Bonovas S, Nikolopoulos GK, Lytras T, Fiorino G, Peyrin-Biroulet L, Danese S. Comparative safety of systemic and low-bioavailability steroids in inflammatory bowel disease: Systematic review and network meta-analysisBritish Journal of Clinical Pharmacology. 2018;84(2):239-251. doi:10.1111/bcp.13456

  3. NIH MedlinePlus. Prednisone. Updated March 15, 2020.

  4. Grennan, D, Wang, S. Steroid side effects. JAMA 2019; 322(3):282

  5. Lichtenstein GR, Loftus EV, Isaacs KL, Regueiro MD, Gerson LB, Sands BE. ACG clinical guideline: management of Crohn’s disease in adultsAmerican Journal of Gastroenterology. 2018;113(4):481-517. doi: 10.1038/ajg.2018.27