Brain & Nervous System Migraines Treatment Migraine Medications That Are Safe During Pregnancy By Colleen Doherty, MD Colleen Doherty, MD Colleen Doherty, MD, is a board-certified internist living with multiple sclerosis. Learn about our editorial process Updated on June 22, 2021 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Huma Sheikh, MD Medically reviewed by Huma Sheikh, MD Facebook LinkedIn Twitter Huma Sheikh, MD, is a board-certified neurologist, specializing in migraine and stroke, and affiliated with Mount Sinai of New York. Learn about our Medical Expert Board Print Thanks to stable levels of migraine-preventive estrogen that occur during pregnancy, women who frequently experience these debilitating headaches often get a reprieve from them when they're expecting. For those in the minority who still get migraines, the question of how to treat them is an important one. While there are several effective medications for the treatment of migraines, not all are considered safe for a developing baby. Migraine pain—if experienced during pregnancy—is often severe enough to require medication. Sometimes other migraine symptoms, such as nausea and vomiting, also must be treated with drugs as well. Fortunately, there are a number of effective migraine medications that the Food and Drug Administration (FDA) considers safe to take during pregnancy. Before reaching for your regular prescription, make sure that it is included in this list (and be sure your obstetrician or midwife approves of you taking a dose). If it's not, discuss these safer options with your healthcare provider. Baby Bonus According to the American Migraine Foundation, as many as 50% to 80% of moms-to-be enjoy fewer headaches. Verywell / JR Bree Pain Medications Also known as analgesics, these are drugs that have the primary purpose of relieving the often excruciating head pain associated with a migraine episode. The analgesics that are most commonly used for head pain are acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs). Both types of drugs are available over the counter (OTC) as brand name, store-brand, and generic products, as well by prescription. Analgesic drugs are also often combined with other medications to create multi-symptom treatments, such as those for coughs and colds. Acetaminophen Considered the safest of pain relief medications for pregnant women and their babies, acetaminophen blocks nerve impulses to the area of the brain where pain signals are produced. There are dozens of brand names for acetaminophen; the most well-known one is Tylenol. A small body of research has found possible associations between prenatal acetaminophen and certain health issues for children. These include asthma, learning problems, attention-deficit/hyperactivity disorder (ADHD), and others. However, according to a 2017 study, any potential links between acetaminophen taken during pregnancy and negative effects on babies are weak at best. For that reason, the author writes, "Acetaminophen should not be withheld from children or pregnant women for fears it might develop adverse effects." Rather than not take acetaminophen for relief from migraine pain, it's advisable for a mom-to-be to always use the lowest dose possible for the shortest amount of time. When not used properly, acetaminophen has been found to cause liver damage in some people (pregnant or otherwise). This is most likely to happen when too much acetaminophen is taken, which often accidentally occurs when acetaminophen is taken at the same time as a combination drug containing it. You can prevent this from happening by carefully reading labels on any drug you take and always checking with your caregiver before you take anything that hasn't been prescribed for you. Know, too, that no one should take more than 4,000 milligrams (mg) of acetaminophen in one day. NSAIDs NSAIDs typically are regarded as the second line of defense against migraine pain during pregnancy. These drugs, which work by decreasing the production of hormone-like compounds called prostaglandins that send pain messages to the brain, include: Aspirin (the most common brand is Bayer)Advil, Motrin (ibuprofen)Aleve (naproxen) In general, NSAIDs are safe for most pregnant women up until the third trimester, according to the Organization of Teratology Information Specialists (OTIS). During the last three months of pregnancy, there is a risk that ibuprofen might cause a blood vessel called the ductus arteriosus to close prematurely, which can affect blood pressure in the developing baby's lungs. OTIS also states that ibuprofen used in late pregnancy might lead to low levels of amniotic fluid or stalled labor. There is some evidence to suggest that use of NSAIDs early in pregnancy (up to eight weeks) could cause bleeding and potential miscarriage, although it is important to note that miscarriage can happen in any pregnancy and often the reason is not specifically known. If you're pregnant and know that ibuprofen works better for your headaches than other pain relievers, talk to your caregiver about how to safely continue to use it during your first and second trimesters. There are several NSAIDs used for migraine pain that are available only by prescription, such as Cambia (diclofenac) and ketoprofen. Like other NSAIDs, these should not be taken after the second trimester of pregnancy. Since it's possible that a medical professional other than your obstetrician might prescribe one of these, be sure to let that doctor know you're pregnant—and check with your OB before taking a prescription NSAID. Finally, note that there are a few health problems associated with NSAIDs that apply to everyone, including an increased risk of heart attack or stroke, especially for people who take these drugs for a long period of time. NSAIDs have also been found to cause ulcers, bleeding, or holes in the stomach or intestines. This risk is especially high for people who take NSAIDs for an extended period of time or who drink a lot of alcohol (something pregnant women are advised against doing anyway). Triptans Medications in this class of prescription drug are most effective for moderate to severe migraines and work best when taken at the earliest sign of an impending attack. Triptans work by stimulating the production of the neurotransmitter (brain chemical) serotonin, thereby reducing inflammation and constricting blood vessels. Triptans also may lower levels of a protein called calcitonin gene-related peptide (CGRP) that is elevated during migraine attacks, and the drugs can be an effective way to relieve nausea and sensitivity to light and sound. The seven triptans used for fending off migraines are: Axert (almotriptan), available as a tablet Relpax (eletriptan), available as a tablet Frova (frovatriptan), available as a tablet Amerge (naratriptan), available as a tablet Maxlt, Maxlt-MLT (rizatriptan), available as a tablet or as a wafer that melts on the tongue Imitrex (sumatriptan), available as a tablet, nasal spray, or subcutaneous (under-the-skin) injection Zomig (zolmitriptan), available as a tablet, nasal spray, or wafer Treximet (sumatriptan combined with the NSAID naproxen), available as a tablet There is some concern that since triptans work by narrowing brain blood vessels, there may be narrowing of the blood vessels that supply the placenta. However, research has found triptans to be safe during pregnancy, with no significant increase in birth defects, prematurity, or miscarriage. Triptans for Migraine Relief Antiemetics Along with headaches, migraines often cause nausea and vomiting, unpleasant symptoms that some women may already experience as the result of their pregnancy (meaning their migraines only make things worse). Given the risks associated with dehydration and difficulty keeping fluids, food, and medication down, drugs called antiemetics often are given to people who seek emergency care for migraines.These usually are given intravenously or by injection into a muscle. While metoclopramide is considered the safest antiemetic for pregnant women, first-trimester exposure to metoclopramide has been associated with an increased risk of genital organ defects.More research is needed to determine whether other antiemetics are safe to use during pregnancy. What Is Morning Sickness? Non-Medication Strategies for Managing Migraine For women looking to avoid medications, the following non-pharmacologic options have been shown to help people better cope with migraine symptoms: Cognitive behavioral therapy, or psychotherapy focused on managing stress Meditation Mindfulness Relaxation How to Prevent Your Migraines Migraine Medications to Avoid During Pregnancy Certain drugs often prescribed for migraine headaches have been associated with an increased risk of serious side effects for moms-to-be and/or their babies. These include: Dihydroergotamine, which is available as D.H.E. 45 or Migranal (an ergot alkaloid) Opioids such as oxycodone and morphine Depakene and Depakote (anticonvulsant valproic acid) A Word From Verywell Most migraine headaches during pregnancy are a nuisance, but not an emergency. However, you should seek medical attention right away if you develop a migraine that doesn't get better with treatment or is accompanied by other symptoms, such as fever or blurred vision. Along with persistent head pain, these can indicate a serious condition such as a stroke, preeclampsia, pituitary tumor, or cerebral venous thrombosis. Seek medical care right away if you experience a migraine along with other symptoms. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 20 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. 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Review of NVP and HG and early pharmacotherapeutic intervention. Obstet Gynecol Int. 2012;2012:252676. doi:10.1155/2012/252676 Bérard A, Sheehy O, Gorgui J, et al. New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. Journal of Clinical Epidemiology. 2019;116:39-48. doi: 10.1016/j.jclinepi.2019.07.014 Puledda F, Shields K. Non-Pharmacological Approaches for Migraine. Neurotherapeutics. 2018;15(2):336-345. doi:10.1007/s13311-018-0623-6 Levin, M, Ward TN. Understanding Your Migraines: A Guide for Patients and Families. Oxford, UK: Oxford University Press. Negro A, Delaruelle Z, Ivanova TA, et al. Headache and pregnancy: a systematic review. J Headache Pain. 2017;18(1):106. doi:10.1186/s10194-017-0816-0 Additional Reading Marchenko A, Etwel F, Olutunfese O, et al. Pregnancy outcome following prenatal exposure to triptan medications: a meta-analysis. Headache. 2015 Apr;55(4):490-501. doi: 10.1111/head.12500