Overview of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

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Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects approximately 2 percent to 10 percent of adult men and causes chronic pelvic pain, in addition to urinary and sexual problems. Once thought to be caused by an infection, that is no longer the case. An exact cause, however, is not known, and diagnosis of CP/CPPS can be challenging, as many other health conditions share its symptoms.

Male doctor and testicular cancer patient are discussing about testicular cancer test report. Testicular cancer and prostate cancer concept.
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The symptoms of CP/CPPS syndrome, include the following:

  • Pain in the lower back, pelvis, bladder, testicles, and penis
  • Pain with ejaculation or urination
  • Difficulty urinating and/or weak urine stream
  • An urgency to urinate or increased urinary frequency
  • Erectile dysfunction
  • Anxiety and depression

With CP/CPPS, a person usually experiences episodes or flares of pain over many months.


It's unclear what causes CP/CPPS syndrome in men. While a bacterial infection of the prostate used to be the suspected culprit, most experts now believe that CP/CPPS is a non-infectious syndrome. The theory that CP/CPPS does not stem from an infection is supported by research that has found no evidence of bacteria in prostate tissue in affected individuals.

Unfortunately, though, experts have still not been able to pinpoint a noninfectious culprit, although suspected ones include the following:

  • Inflammation from trauma
  • Autoimmune process
  • Abnormal reaction to normal prostate bacterial flora
  • Increase prostate tissue pressure
  • Psychological stress (not a primary cause, but may contribute to the pain)

More specifically, many experts believe that an event (like one of the above) triggers a phenomenon called central sensitization. This then leads to persistent neuropathic pain, similar to what is seen in other chronic pain conditions like fibromyalgia and irritable bowel syndrome.


The diagnosis of CP/CPPS can be tricky because many other health conditions mimic its symptoms. Some of them include:

  • Acute bacterial prostatitis
  • Urinary tract infection
  • Sexually transmitted infections
  • Colorectal, prostate, bladder, or testicular cancer
  • An inguinal hernia
  • Benign prostatic hyperplasia
  • Pelvic floor dysfunction
  • Bladder stones
  • Neurogenic bladder
  • Pudendal neuralgia

Due to the fact that CP/CPPS is a diagnosis of exclusion, meaning other health problems need to be ruled out first, a thorough medical history and physical examination is an essential first step.

In addition to a history and physical examination, laboratory tests are also performed, such as a urinalysis and urine culture. Depending on a person's unique symptoms, a prostate-specific antigen (PSA) blood test, urine cytology, urethral discharge culture, and a complete blood count (CBC) may be performed.

Various imaging tests may also be warranted, again based on a person's individual symptoms. For example, if a man has blood in his urine, a cystoscopy to exclude bladder cancer will likely be performed. Likewise, testicular pain warrants a scrotal ultrasound and lower abdominal pain often warrants a computed tomography (CT) scan of the abdomen and pelvis.


The treatment of CP/CPPS usually begins with a combination of three medications: an antibiotic, an alpha-blocker like Flomax (tamsulosin), and a pain medication, like Tylenol (acetaminophen) or a nonsteroidal anti-inflammatory (NSAID). Sometimes, a medication to treat nerve pain like Lyrica (pregabalin) is also prescribed.

Non-medication therapies are also often used for managing the symptoms of CP/CPPS. According to a Cochrane Review, these therapies may help ease the symptoms of CP/CPPS:

  • Acupuncture
  • A physical activity program
  • Extracorporeal shockwave therapy (a procedure in which shock waves are passed through the skin to the prostate)
  • Transrectal thermotherapy (a procedure in which heat is applied to the prostate and pelvic muscle area)

In addition, research suggests that cognitive-behavioral therapy can help relieve the symptoms of CP/CPPS, especially pain, urinary problems, and depression. Cognitive-behavioral therapy has also been found to improve a man's overall quality of life.

Lastly, pelvic physical therapy to achieve myofascial trigger point release may be useful for men who experience pelvic pain related to pelvic floor muscle spasm.

A Word From Verywell

In the end, CP/CPPS is a complex disease and getting it diagnosed can be a lengthy, tricky process. Once diagnosed, most people benefit from a multifaceted treatment program (one that includes both medication and non-medication treatments), but getting there can be a windy, bumpy road. Remain persistent and proactive in your care, and consider engaging several different healthcare practitioners (who ideally work in concert) to find relief.

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7 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  2. Harvard Medical School Harvard Health Publishing. Chronic nonbacterial prostatitis (chronic pelvic pain syndrome). Updated August 20, 2019.

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  4. Arora HC, Eng C, Shoskes DA. Gut microbiome and chronic prostatitis/chronic pelvic pain syndrome. Ann. Transl. Med. 2017;5:30-30. doi:10.21037/atm.2016.12.32

  5. Rees J, Abrahams M, Doble A, Cooper A. Diagnosis and treatment of chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome: a consensus guideline. BJU Int. 2015;116(4):509-525. doi:10.1111/bju.13101

  6. Franco JV, Turk T, Jung JH, et al. Non-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome. Cochrane Database Syst Rev. 2018;26;1:CD012551. doi:10.1002/14651858.CD012551.pub2

  7. Herati AS, Moldwin RM. Alternative therapies in the management of chronic prostatitis/chronic pelvic pain syndrome. World J Urol. 2013; 31(4):761-766. doi:10.1007/s00345-013-1097-0

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