Understanding Prurigo Simplex

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Prurigo simplex is a form of skin disease. The term prurigo is used to describe the presence of spots on the skin that are extremely itchy. The bumps associated with prurigo simplex are similar to bug bites. Other skin diseases also develop prurigo but are not the same as prurigo simplex.

In prurigo simplex, itchy bumps develop without any provocation. In addition, the spots and rash associated with chronic prurigo and other skin diseases develop after scratching, making them secondary conditions.

This article discusses the causes, symptoms, and treatment options for prurigo simplex.

Woman scratching arm

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What Causes Prurigo Simplex? 

While prurigo simplex is typically considered idiopathic (occurring spontaneously or from an unknown cause), some underlying health disorders are commonly associated with the condition.

Conditions such as diabetes and kidney or liver dysfunction have commonly been found alongside prurigo simplex. Mental health disorders have also been linked to the condition, especially in women between 40 and 60.

Prurigo Simplex Triggers

There are certain environmental triggers associated with prurigo simplex, such as being exposed to either extremely hot or extremely cold temperatures. Other possible factors that may trigger prurigo simplex include:

  • Being overly exposed to sunlight
  • Some foods or medications
  • Allergies
  • Emotional stress  
  • Being exposed to bacteria or parasites on the skin


The main symptom of prurigo simplex is spots that develop on the skin. These are typically small in size and shaped like domes. In some cases, small blisters form on the skin as well.

When the spots or blisters develop, they are symmetrical, meaning they appear in equal amounts on both sides of the body. The areas of the body most affected include:

  • Legs
  • Arms
  • Buttocks

The head, neck, and torso can also be affected. The one main characterization of the spots is intense itch. People with the disorder may also experience dermographism, a skin condition that appears with swelling or red lines on the skin after only mild pressure or scratching is applied to the area.

Prurigo Simplex and Overall Health

Even though the symptoms of prurigo simplex are typically isolated to one affected area, the intense itch leads to issues with sleeping. Over time, this can compromise a person’s overall health.  


Diagnosing prurigo simplex may require several different tests as it can be caused by many factors. These tests are used to help rule out other causes of prurigo and if there are any other underlying health issues at play. 

A skin biopsy is used to check for other skin conditions such as dermatitis herpetiformis, a herpes-like skin disorder that develops in people with celiac disease.

Immunofluorescence may be used in the diagnostic process of prurigo simplex. This test uses a dye to highlight immune system dysfunction often seen in various types of skin disorders.

Other tests also used to rule out other conditions include:

  • Blood tests to examine liver and kidney function.
  • Blood tests to determine if the immune system is working properly. This test is done because many skin diseases develop because the immune system attacks healthy skin tissue by mistake.
  • CT scans and MRI scans grant healthcare providers a more in-depth look into what’s happening in the skin tissue.

Prurigo Simplex and Physical Examinations

While prurigo simplex can be seen with the naked eye, it looks similar to several other disorders. That is why the diagnostic process involves many screening tests.


There is no cure for prurigo simplex, but once the condition is diagnosed, treatment can begin to manage symptoms. Unfortunately, some of the most common treatments for other skin diseases, such as antihistamines and topical steroids, do not always work well for people with prurigo simplex.

Some effective treatment options include:

  • Systemic steroids: Synthetic forms of natural steroids found within the body. These medications are given orally or through a needle directly into a vein (intravenously).
  • Phototherapy: Uses ultraviolet light as a way to heal the skin and get rid of symptoms.
  • Immune-suppressing medications: Medications like Methotrexate or Cyclosporine work to slow down or stop the immune system from overreacting.
  • Psychological medications or therapies

When to See a Healthcare Provider

If you experience any type of intense itchiness and raised bumps on the skin, you should see your healthcare provider. While many of the conditions associated with these symptoms are non-life-threatening, getting the proper diagnosis quickly can help relieve the itching. The sooner you start treatment, the sooner you can manage symptoms of prurigo simplex.


Prurigo simplex is a form of skin disease that typically develops on its own without the presence of an underlying skin disorder. A person with the condition experiences intense itchiness and raised bumps on the skin. These bumps are typically small and some can develop into blisters.

While the cause isn't well known, some factors come into play regarding how it develops. These factors can include extreme hot or cold exposure and a person's overall stress level. Certain health conditions that affect the kidneys, liver, or the way the body processes food into energy can also play a role. Prurigo simplex has also been associated with mental health disorders.

Diagnosing the condition early using various blood tests, scans, or a skin biopsy to rule out other skin disorders is important to start treatment. While treatment will not be able to completely cure prurigo simplex, there are several effective treatment options that relieve symptoms.

A Word From Verywell 

Dealing with the intense itchiness involved in prurigo simplex can be excruciating, especially if you are not sure what is causing it. Discuss any type of new intense itches or bumps with your healthcare provider. These disorders are often easy to cope with once treatment is in place. Getting diagnosed quickly can keep you from having to deal with the symptoms longer than you have to.

Frequently Asked Questions

  • Is prurigo simplex contagious?

    While the rash-like area affected by the condition may be alarming, it is not contagious. If you do have the condition, you will not pass it on to others.

  • Is there a cure for prurigo simplex?

    Just like many other skin diseases that present with intense itchiness, there is no cure for prurigo simplex. That said, people with the disorder don’t have to suffer the symptoms in silence. There are several treatment options that are highly effective at relieving symptoms.

  • How do you get prurigo simplex?

    The direct cause of prurigo simplex isn’t clear but there are some existing factors related to the condition, including:

    • Liver and kidney dysfunction
    • Diabetes
    • Mental health disorders
    • Exposure to extreme hot or cold temperatures
    • Prolonged sunlight exposure
    • Stress
4 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Wallengren J. Prurigo simplex or "itchy red bump" disease: review and case series. Acta Derm Venereol. 2021;101(9):adv00539. doi:10.2340/00015555-3912

  2. Akar HH, Tahan F, Balkanli S, Sadet Özcan S. Prurigo simplex subacuta or prurigo simplex acuta? Eur Ann Allergy Clin Immunol. 2014;46(4):152-153.

  3. DermNet NZ. Prurigo: signs and symptoms.

  4. American Academy of Dermatology Association. Prurigo nodularis: overview.

By Angelica Bottaro
Angelica Bottaro is a professional freelance writer with over 5 years of experience. She has been educated in both psychology and journalism, and her dual education has given her the research and writing skills needed to deliver sound and engaging content in the health space.