The Best Medications for the Treatment of Psoriasis

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There are many approaches to treating psoriasis. Skin care methods and at-home remedies are used by many, but they may not work for everyone. Sometimes medical or pharmaceutical treatment is needed. These can include over-the-counter products, prescription medications, or biologics.

This article reviews the different medications for psoriasis treatment.

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Types of Psoriasis Medication

Treatments for autoimmune conditions focus on reducing or controlling the immune system response in your body. Sometimes, localized psoriasis treatments are used to treat a small patch of affected skin. Other times, systemic therapies are required to manage psoriasis.

Systemic treatments are those that work throughout the body, reaching all areas by traveling through the bloodstream. Systemic psoriasis drugs can be grouped into two categories: biologics and pharmaceuticals. Your healthcare team will consider your situation and discuss different treatment options.

Systemic therapy usually is reserved for people with severe psoriatic disease. "Severe" is defined as psoriasis covering more than 5% of the body's surface or involves high-impact areas like the face or genitals.

Generally, psoriasis medications decrease the symptoms of active psoriasis and help reduce the risk of long-term comorbidities (health conditions that occur with psoriasis). Comorbidities include:

In the United States, the Food and Drug Administration (FDA) regulates the manufacturing of both pharmaceuticals and biologics.

Biologics for Psoriasis

Biologics, sometimes called biopharmaceuticals, are made using living organisms like human cells, animal cells, or small microorganisms like bacteria or viruses. Vaccines are biologics that have been around for hundreds of years.

There are several classes of biologics available to treat psoriasis. Each type of drug affects a different part of the immune system.

Tumor Necrosis Factor-Alpha (TNF-alpha) Inhibitors

Tumor necrosis factor-alpha (TNF-alpha) inhibitors work by inhibiting, or blocking, the TNF-alpha cytokine. Cytokines are signal proteins that produce inflammation in the body. Too much TNF-alpha is present in some people, which leads to inflammation, joint damage, and psoriasis symptoms.

TNF-alpha inhibitor drugs reduce the inflammatory response by preventing the cytokines from reaching the receptors. This can help decrease symptoms of psoriasis in some people. TNF-alpha inhibitors for psoriasis include:

Interleukin Inhibitors

Interleukin (IL) is another cytokine protein produced in leukocytes, a type of white blood cell, and in other cells in the body. These signal proteins regulate the immune response. Interleukins are named using numbers and specific proteins that are associated with the inflammation that occurs with psoriasis. Blocking these proteins can help improve the symptoms of psoriasis.

Some interleukin inhibitors used are:

Using biologic medications may raise your risk of serious infection. Be sure to follow all the recommendations from your healthcare provider for self-monitoring and screening. See your provider for any signs of infection, including fevers or chills.

Treatments are being studied, and new biologics are being developed. Speak with your healthcare provider to see what is recommended for your specific condition.

Pharmaceuticals for Psoriasis

Pharmaceuticals are created from chemicals in a lab or manufacturing plant. They can be over-the-counter (OTC) medications or may require a prescription from a healthcare provider.

Several pharmaceutical treatments are available for psoriasis. All have different methods of effectiveness and vary in their side effects. Some pharmaceutical psoriasis treatments may include:

Some second-tier medications have been used to treat psoriasis. They are less effective and less commonly used than the drugs listed.

Other Treatment Options

Different combinations of psoriasis treatments are being evaluated. Be sure your healthcare team knows about your medications, including OTC medicines or creams.

Your medical team will evaluate the location and severity of your psoriasis and make recommendations about what treatments to start with. Most systemic biologic and pharmaceutical treatments are given by infusion (intravenously) or injection.

For mild or moderate psoriasis, your healthcare provider may recommend topical treatments, phototherapy (light therapy), or a combination of different therapies for your treatment.

Topical Treatments

Topical treatments are applied directly to psoriasis plaques on the skin to treat the affected areas. Many of these treatments help reduce the inflammation at the site of the psoriasis flare. Some may be purchased without a prescription, while others will require one.

Topical medications for psoriasis may include:

  • Corticosteroids: Steroid medications reduce the inflammatory response and can help reduce and heal psoriasis plaques.
  • Vitamin D analogs: Vitamin D helps lessens psoriasis plaques by reducing how fast skin cells grow. Vectical (calcitriol) is a naturally occurring substance, and Dovonex (calcipotriene) is a chemically created (synthetic) type. Both are used topically to treat psoriasis.
  • Retinol: Tazorec (tazarotene) is a vitamin A retinoid. It also lowers the rate of skin cell growth and helps to minimize psoriasis plaques.
  • Calcineurin inhibitors: Protopic (tacrolimus ointment) and Elidel (1.0% pimecrolimus cream) have been used off-label to treat psoriasis. They also help lessen inflammation and slow skin cell growth.


Phototherapy is a treatment that uses ultraviolet (UV) light on patches of skin affected by psoriasis. Phototherapy requires the skin to be exposed to light for a specific amount of time regularly. Treatment can be performed at the provider's office or home. A prescription is required for the equipment used at home.

Depending on your healthcare provider's recommendations, phototherapy can be combined with other therapies, including topical or systemic treatments.


Psoriasis is an incurable autoimmune condition that primarily affects the skin. It can cause discomfort or unwanted cosmetic appearance changes. Systemic treatments are available, including pharmaceuticals and biologics. Each treatment has potential side effects. The treatment approach should be decided in conversation with your healthcare team, considering your lifestyle, preferences, and other health conditions you may have.

A Word From Verywell

Psoriasis can flare up during stressful times. Many different treatments can help control the immune system and help heal the plaques that come from rapid skin cell growth. You may benefit from a combination of lifestyle modifications and different treatments to best manage your psoriasis.

Frequently Asked Questions

  • What is the fastest treatment for psoriasis?

    The best psoriasis treatment will depend on the kind and severity of your disease. Talk with your healthcare provider about best managing your specific health condition. Topical agents, phototherapy, or systemic treatments (pharmaceuticals or biologics) may help improve your skin.

  • Is psoriasis curable?

    Unfortunately, there is no cure for psoriasis. Understanding what triggers in your life worsen your psoriasis symptoms may help you prevent flare-ups. Talk with your healthcare provider about different treatments you can use to help manage your psoriasis.

  • What are biologics and why are they effective at treating psoriasis?

    Biologics are medications derived from living tissues (human cells, animal cells, or microorganisms). They specifically target the part of the immune system that causes inflammation. Because of this, they are very helpful in managing psoriasis.

11 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. National Cancer Institute. Systemic therapy.

  2. Weigle N, McBane S. PsoriasisAm Fam Physician. 2013;87(9):626-633.

  3. National Psoriasis Foundation. Related conditions of psoriasis.

  4. Developing and manufacturing drugs including biologics.

  5. Morrow T, Felcone LH. Defining the difference: what makes biologics uniqueBiotechnol Healthc. 2004;1(4):24-29.

  6. Saleh A, Qamar S, Tekin A, Singh R, Kashyap R. Vaccine development throughout historyCureus. doi:0.7759/cureus.16635

  7. National Psoriasis Foundation. Current biologics on the market.

  8. National Cancer Institute. Interleukin.

  9. National Psoriasis Foundation. Topicals.

  10. National Psoriasis Foundation. Phototherapy.

  11. Biologics.