Arthritis Treatment What to Know About Rayos (Prednisone) for Rheumatoid Arthritis A delayed-release corticosteroid for RA By Carol Eustice Carol Eustice Facebook Carol Eustice is a writer covering arthritis and chronic illness, who herself has been diagnosed with both rheumatoid arthritis and osteoarthritis. Learn about our editorial process Updated on May 25, 2022 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Anita C. Chandrasekaran, MD, MPH Medically reviewed by Anita C. Chandrasekaran, MD, MPH LinkedIn Anita Chandrasekaran, MD, MPH, is board-certified in internal medicine and rheumatology and currently works as a rheumatologist at Hartford Healthcare Medical Group in Connecticut. Learn about our Medical Expert Board Print Table of Contents View All Table of Contents Uses Before Taking Dosage Side Effects Warnings/Interactions Rayos (delayed-release prednisone) is a delayed-release formulation of low-dose prednisone, which is a corticosteroid. In 2012, this oral drug gained U.S. Food and Drug Administration (FDA) approval as a treatment for rheumatoid arthritis (RA). It's also used to treat several other conditions. Prednisone has been on the U.S. market since 1955. In autoimmune diseases, including RA, the immune system mistakenly launches an attack on healthy tissue. Prednisone is a common treatment for RA because it counters inflammation. Rayos is known in Europe by the brand name Lodotra. So far, it's not available in generic forms or under other brand names. Daniel Grill/Brand X Pictures/Getty Images Uses In RA, the joints are the primary target for an immune system gone awry. The immune response triggers inflammation in the joints, which leads to pain, limited range of motion, and, eventually, permanent damage. Early, aggressive treatment can prevent or delay permanent damage and the disability associated with this condition, and corticosteroids like Rayos can be a useful part of that treatment. Rayos works differently than immediate-release prednisone. Due to Rayos's formulation, taking the drug before bed allows it to take effect in the middle of the night—when certain cells in the immune system, called cytokines, start to increase. This mechanism of action appears to provide better control of cytokine-related inflammation for some people. Rayos and other types of prednisone are typically used for short-term relief of inflammation. The American College of Rheumatology guidelines from 2021 state that steroids should be used for 3 months or less in the treatment of RA, and at the lowest effective dose. Rayos is also FDA-approved for reducing the inflammatory response for people who have organ transplantation and for treating many conditions, including other rheumatologic diseases, dermatologic issues, endocrine conditions, gastrointestinal disorders, respiratory diseases, infectious diseases, and more. Besides RA, rheumatologic conditions Rayos may be used for include: Gouty arthritis Ankylosing spondylitis Dermatomyositis Polymyositis Polymyalgia rheumatica Psoriatic arthritis Relapsing polychondritis Sjögren's syndrome Systemic lupus erythematosus Vasculitis Your healthcare provider may consider Rayos for you if you've recently been diagnosed with RA and are waiting to see the effects of a disease-modifying anti-rheumatic drug (DMARD) such as methotrexate, sulfasalazine, or hydroxychloroquine. The effects of DMARDs can take weeks or months to become evident, so prednisone and other corticosteroids play an important role during that time. Later in the course of the disease, you may be given Rayos during RA symptom flares to help get your inflammation under control quickly. What You Should Know About DMARDs Before Taking Before taking Rayos, tell your healthcare provider if you've ever had an allergic reaction to prednisone, similar drugs, or any of the active ingredients in Rayos. Also, be sure to mention whether you've had recent or ongoing infections and whether you've recently had any vaccines. Always be sure your practitioner knows all the treatments you're using, including prescription drugs, over-the-counter medications, and supplements. This can help you avoid dangerous side effects and interactions that may be caused by certain combinations of therapies. Precautions and Contraindications People with certain health conditions shouldn't take Rayos, may need special monitoring while they're on it, or may need to discontinue other over-the-counter or prescription medications before taking Rayos. Be sure to tell your healthcare provider if you have: Recurrent eye infections (present or past) Threadworms Diabetes High blood pressure Mental health issues Myasthenia gravis Osteoporosis Seizures Tuberculosis Ulcers Liver disease Kidney disease Intestinal disease Heart disease Thyroid disease You shouldn't start taking prednisone while you're pregnant, if you're trying to conceive, or while you have an infection. Other Corticosteroids It is usually not recommended to take more than one steroid drug at a time. Corticosteroids have been around a long time, and many of them are sold under numerous brand names. Because of this, they're often best known by their generic names. Generic names of corticosteroid drugs include: Hydrocortisone Cortisone Prednisolone Triamcinolone Betamethasone Triamcinolone Methylprednisolone Dexamethasone Fludrocortisone Some of these are primarily taken orally, while others may be used topically or taken via injection. Some are available in multiple forms. Dosage Rayos is available in delayed-release tablets of 1 milligram (mg), 2 mg, and 5 mg strengths. Your healthcare provider should determine the correct dosage for you based on several factors, including your disease severity and whether you've been using immediate-release prednisone. Typically, the starting dose is 5 mg of Rayos once a day. However, if you've been taking rapid-release prednisone, prednisolone, or methylprednisolone, you should be given an equivalent initial dose of Rayos. This may not be the same in milligrams, but it will be the same in strength. You should remain on the lowest amount that's effective for your symptoms. Don't stop taking Rayos without talking to your practitioner. When going off of long-term or high-dose Rayos, you should do so gradually to avoid withdrawal effects. Your healthcare provider can advise you on how to properly taper this medication. How to Take and Store Rayos should be taken daily and with food. The pill must be swallowed whole—not cut, broken, or chewed—as this will interfere with the rate of release. Because the drug begins to get released four hours after taking the pill, it's commonly taken before bed. Rayos should be stored at about room temperature, with the optimal temperature of 77 degrees F. If you're carrying the medication with you while you're away from home, short stints of temperatures down to 59 degrees F and up to 86 degrees F are acceptable. You should keep Rayos tablets away from light and moisture. Side Effects As with any drug you are considering taking, Rayos's benefits must be weighed against potential side effects. Common The most common side effects of Rayos include: Fluid retentionElevation in blood pressureChange in glucose toleranceMood changesWeight gainIncreased appetite If any of these side effects become severe or don't go away with time, talk to your healthcare provider. Severe More severe side effects are possible with Rayos and can have wide-ranging effects. Allergic reactions: Hives, low blood pressure, trouble breathing, weak and rapid pulse, dizziness or fainting, nausea, vomiting, diarrhea Cardiovascular: Cardiac arrest, arrhythmias, vasculitis, fainting (syncope), and more Skin: Acne, dry scalp, impaired wound healing, increased sweating, hair loss, and more Endocrine: Menstrual irregularities, abnormal fat deposits, development of Cushingoid state, new-onset diabetes, altered insulin requirements in people with diabetes, suppressed growth in children, and more Fluid and electrolyte disturbances: Fluid retention (edema), potassium loss, high blood pressure, hypokalemic alkalosis, sodium retention Gastrointestinal: Abdominal distention, elevated serum liver enzyme levels, hepatomegaly, hiccups, nausea, pancreatitis, peptic ulcer, and more General: Increased appetite and weight gain Metabolic: Negative nitrogen balance due to protein catabolism Musculoskeletal: Osteonecrosis of femoral (thigh bone) and humeral (arm bone) heads, loss of muscle mass, muscle weakness, osteoporosis, steroid myopathy, tendon rupture, vertebral compression fractures, and others Neurological: Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure (usually following discontinuation), insomnia, meningitis, neuropathy, paraplegia, sensory disturbances, vertigo, and more Ophthalmic: Glaucoma, increased eye pressure, posterior subcapsular cataracts, and more Reproductive: Decrease in sperm count and lowered motility If you experience any new symptoms while taking this medication, contact your healthcare provider right away. Need for Monitoring While you're on Rayos, you'll need to be monitored for suppression of the hypothalamic-pituitary-adrenal (HPA) axis (your body's stress-response system), Cushing's syndrome, and high blood sugars (hyperglycemia). Your blood pressure, sodium levels, and potassium levels should be closely watched as well. Be sure to get all of the tests your healthcare provider suggests and to do so on schedule. Warnings and Interactions This drug will make you more susceptible to new infections and could cause a reactivation of latent chronic infections, so it's especially important to tell your healthcare provider about any symptoms of infection (e.g., fever, chills, sore throat). In addition, you should not get live or live-attenuated vaccines while taking an immunosuppressive dose of prednisone. Pregnant or Nursing Women Taking Rayos during the first trimester of pregnancy can harm your baby. It's associated with an increased risk of cleft lip and cleft palate, restricted growth, small birth weight, and premature birth. In animals, it's also been associated with miscarriages. This drug does pass into breast milk and may cause problems with your child's growth and development. You and your healthcare provider should carefully weigh the benefits of this drug with the serious risks it poses to your baby. Drug Combinations Prednisone can negatively interact with a long list of drugs and supplements, including common over-the-counter products such as: Aspirin Motrin/Advil (ibuprofen) Aleve (naproxen) St. John's wort (an herbal supplement) Some common classes of drugs that can cause problems with Rayos are: Anticoagulants (blood thinners) Antidiabetic agents Antidepressants Antifungals Other corticosteroids CYP3A4 inducers and inhibitors Cyclosporine Diuretics (water pills) HIV protease inhibitors Hormonal contraceptives, including birth control pills, patches, implants, and other forms Potassium-depleting agents You and your healthcare provider need to carefully evaluate the potential risks and benefits of Rayos before you start taking it, as your health changes over time, and whenever you start new medications. Treating Rheumatoid Arthritis—Effectively Was this page helpful? Thanks for your feedback! Dealing with chronic inflammation? An anti-inflammatory diet can help. Our free recipe guide shows you the best foods to fight inflammation. Get yours today! Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 4 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Johns Hopkins Arthritis Center. Rheumatoid arthritis treatment. Kim D, Choi CB, Lee J, et al. Impact of early diagnosis on functional disability in rheumatoid arthritis. Korean J Intern Med. 2017;32(4):738-746. doi:10.3904/kjim.2015.364 Palmsten K, Bandoli G, Watkins J, Vazquez-Benitez G, Gilmer TP, Chambers CD. Oral corticosteroids and risk of preterm birth in the California Medicaid program [published online ahead of print, 2020 Aug 11]. J Allergy Clin Immunol Pract. 2020;S2213-2198(20)30805-9. doi:10.1016/j.jaip.2020.07.047 National Institutes of Health, U.S. National Library of Medicine: MedlinePlus. Prednisone. Additional Reading U.S. Food and Drug Administration: FDA AccessData. Rayos: Highlights of prescribing information and Full prescribing information.