An Overview of Restless Legs Syndrome in Multiple Sclerosis

Is RLS Contributing to Your Fatigue?

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Research shows that people with multiple sclerosis (MS) are about four times more likely to have restless legs syndrome (RLS) than people in the general population. Restless legs syndrome is a sleep disorder that is often associated with spontaneous, jerking leg movements called periodic leg movements.

The syndrome can be disruptive to sleep and contribute to the overall fatigue common in people with MS.

Restless Leg Syndrome Common Symptoms
Verywell / Gary Ferster


RLS is a movement disorder that is characterized by unpleasant feelings in the legs that is associated with a need to move. The sensations may include:

  • Aches
  • Pulling
  • Itching
  • A sensation of bugs crawling under the skin
  • Tingling
  • Tightness
  • Electrical or jolting sensations

These symptoms typically come on during periods of rest, especially at night, and are relieved by movement. They may make it hard to fall or stay asleep, resulting in sleep-onset insomnia.

If you have RLS, it is probably contributing to your MS-related fatigue by causing you to lose sleep. This is called secondary fatigue, as the tiredness is a result of symptoms or insomnia. (The primary cause of fatigue for people with MS is the demyelination of nerves and the disease process of MS itself.)


RLS may be related to abnormalities in neurotransmitters that help regulate muscle movements or in the part of the central nervous system that controls automatic movements.

According to research, people with MS who have a more severe disease course—primary progressive MS (PPMS)—and lesions in their cervical spinal cord are at a higher risk for having restless legs syndrome.


Restless legs syndrome is diagnosed when the following criteria are met:

  • There is an urge to move the legs (usually caused by or accompanied by uncomfortable or unpleasant sensations in the legs).
  • This urge to move gets worse when you are still (usually lying down, but it can also occur when sitting).
  • Moving around eases (at least partially) the urge to move or the unpleasant sensation.
  • The urge is much worse at night than during the day.

While these symptoms can be due to restless legs syndrome that co-occurs with multiple sclerosis, know that MS itself can cause symptoms that mimic (and can be mistaken for) RLS, too.

  • Extensor spasms: These happen when a limb stiffens and the person is unable to bend the joint. These cause the limb, usually a leg, to jerk away from the body. Muscle spasms usually affect the quadriceps (the large muscles on the front of the thigh), causing the lower leg to straighten. In fact, some extensor spasms can be so sudden and strong that the person can fall out of a chair or bed. Extensor spasms are involuntary movements, rather than an “urge.” They are not relieved by movement, but can actually be the result of trying to move, such as turning over in bed or trying to move to a wheelchair.
  • Paresthesias: These include unpleasant sensations that occur primarily in the lower legs and feet. They feel like numbness or tingling, or like pins-and-needles. These feelings are also very distinct from the unpleasant sensations of RLS, as there is no relief from them when the person is moving. They are also usually present in the day as well as the night.

Your healthcare provider will be able to discern the nuances, and it's helpful to provide a detailed account of when you experience symptoms.

Leg Symptoms Due to MS
  • Spasms are involuntary

  • Unpleasant sensations and muscle stiffening not improved with movement

  • Sensations present day and night

Leg Symptoms Due to RLS
  • Movement brought on by an urge

  • Typically worse at night

  • Unpleasant sensations eased with movement


Depending on how often your restless legs syndrome acts up, the following treatments may be used:

  • Mentally stimulating activities, such as doing crossword puzzles
  • Avoidance of aggravating factors, possibly including certain medications
  • Moderate regular exercise
  • Reduced caffeine intake
  • For symptomatic relief—walking, bicycling, soaking the affected limbs, and leg massage, including pneumatic compression
  • Neurontin (gabapentin), which is used to treat neuropathic pain, a common symptom in patients with multiple sclerosis
  • Benzodiazepines or benzodiazepine agonists, such as Valium (diazepam) and Klonopin (clonazepam): These have been used with success, but could also cause fatigue to worsen. They likely to only be used if you need some help for a week or two at a time, as they can be habit-forming.
  • Medications that increase dopamine in the brain, such as Requip (ropinirole) and Mirapex (pramipexole)

A Word From ​Verywell

If you have MS, you likely experience assorted unpleasant sensations, as well as fatigue and difficulty sleeping. Many people with MS say that fatigue is their most disabling symptom. Add sleepless nights due to RLS, and it may mean the difference between “getting by” and complete inability to function. Fortunately, restless legs syndrome is very treatable. If you have RLS symptoms, a visit to your neurologist is in order.

7 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  2. Didato G, Di Giacomo R, Rosa GJ, Dominese A, de Curtis M, Lanteri P. Restless legs syndrome across the lifespan: symptoms, pathophysiology, management and daily life impact of the different patterns of disease presentation. Int J Environ Res Public Health. 2020;17(10):3658. doi:10.3390/ijerph17103658

  3. Strober LB. Fatigue in multiple sclerosis: a look at the role of poor sleep. Front Neurol. 2015;6:21. doi:10.3389/fneur.2015.00021

  4. Monschein T, Schestak C, Schillerwein-Kral C, et al. Restless legs syndrome in multiple sclerosis: risk factors and effect on sleep quality – a case-control study. Mult Scler Relat Disord. 2021;51:102916. doi:10.1016/j.msard.2021.102916

  5. Klingelhoefer L, Bhattacharya K, Reichmann H. Restless legs syndrome. Clin Med. 2016;16(4):379-382. doi:10.7861/clinmedicine.16-4-379

  6. National Multiple Sclerosis Society. Spasticity.

  7. National Multiple Sclerosis Society. Numbness or tingling.

Additional Reading

By Julie Stachowiak, PhD
Julie Stachowiak, PhD, is the author of the Multiple Sclerosis Manifesto, the winner of the 2009 ForeWord Book of the Year Award, Health Category.