Russell-Silver Syndrome In Children and Adults

A Disease That Affects Growth Features

Russell-Silver syndrome is a type of growth disorder usually accompanied by distinctive facial features, and often by asymmetric limbs. It is sometimes also called Silver-Russell syndrome or Silver-Russell dwarfism.

Babies with this condition typically have difficulty feeding and growing. Although adolescents and adults with Russell-Silver syndrome will be shorter than average, Russell-Silver syndrome does not significantly impact life expectancy.

Russell-Silver syndrome affects all genders and people of all ethnic backgrounds.

Child having height recorded by a doctor
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Causes

Russell-Silver syndrome is now thought to be a genetic disorder, caused by abnormalities in either chromosome 7 or chromosome 11. Specifically, Russell-Silver syndrome is related to problems with some of the genes that control growth.

In about 40% of cases, the cause of Russell-Silver syndrome isn't known. It is thought that these cases may be caused by problems with genes on other chromosomes, which have yet to be identified.

Most cases are not inherited but are thought to be due to spontaneous mutations.

Symptoms

Failure to grow is the primary symptom of Russell-Silver syndrome. Other symptoms include:

  • Low birthweight
  • Distinctive facial features which include a small triangular face (a high forehead that tapers to a small jaw), prominent nasal bridge, and down-turning corners of the mouth
  • A normal-sized head but because the body is small, the head looks large in comparison
  • Overgrowth of one side of the body, resulting in asymmetry of arms and/or legs
  • Defects of fingers and toes, such as curving in or fusion

Diagnosis

In general, the most noticeable symptom of Russell-Silver syndrome is a child’s failure to grow, and this may suggest the diagnosis. The infant is born small and does not achieve normal lengths/heights for his/her age. The distinctive facial features may be identified in infants and children. In teenagers and adults with Russell-Silver syndrome, they may be harder to recognize.

Testing for Russell-Silver syndrome may include genetic testing to rule out other genetic disorders that may have similar symptoms.

Treatment

Because children with Russell-Silver syndrome have difficulty consuming enough calories for growth, parents need to learn how to optimize calorie intake, and special high-calorie formulas may be given. In many cases, a feeding tube will be necessary to help the child achieve optimal nutrition.​

Growth hormone therapy can help the child grow more rapidly, but he or she will still be shorter than average. Early intervention programs for young children are helpful since some children with Russell-Silver syndrome have learning disabilities, including developmental and speech delays. In addition, physical and occupational therapy are helpful to promote physical development.

4 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. National Organization for Rare Disorders. Russell Silver Syndrome.

  2. National Library of Medicine. Russell-Silver syndrome.

  3. Smeets C, Zandwijken G, Renes J, Hokken-Koelega A. Long-Term Results of GH Treatment in Silver-Russell Syndrome (SRS): Do They Benefit the Same as Non-SRS Short-SGA?. The Journal of Clinical Endocrinology & Metabolism. 2016;101(5):2105-2112. doi:10.1210/jc.2015-4273

  4. Burgevin M, Lacroix A, Brown G, Mikaty M, Coutinho V, Netchine I, Odent S. Intellectual functioning in Silver-Russell syndrome: first study in adults. Appl Neuropsychol. 2021;28(4):391-402. doi:10.1080/23279095.2019.1644643

Additional Reading

By Mary Kugler, RN
Mary Kugler, RN, is a pediatric nurse whose specialty is caring for children with long-term or severe medical problems.