Cancer More Cancer Types Sarcomas Are Malignant Connective Tissue Cancer By Jonathan Cluett, MD Jonathan Cluett, MD LinkedIn Twitter Jonathan Cluett, MD, is board-certified in orthopedic surgery. He served as assistant team physician to Chivas USA (Major League Soccer) and the United States men's and women's national soccer teams. Learn about our editorial process Updated on January 21, 2022 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Doru Paul, MD Medically reviewed by Doru Paul, MD Doru Paul, MD, is board-certified in internal medicine, medical oncology, and hematology. Learn about our Medical Expert Board Fact checked Verywell Health content is rigorously reviewed by a team of qualified and experienced fact checkers. Fact checkers review articles for factual accuracy, relevance, and timeliness. We rely on the most current and reputable sources, which are cited in the text and listed at the bottom of each article. Content is fact checked after it has been edited and before publication. Learn more. by Heather Mercer Fact checked by Heather Mercer Heather Mercer is native to Northwest Ohio (go Walleye!) and graduated from Loma Linda University with two doctorate degrees (psychology and public health). She is currently a professor at Owens Community College, as well as a fact-checker for Verywell Health. She has gained experience in a variety of settings, ranging from corporate wellness and preventive medicine, to mental health, chronic disease, and end-of-life care. Learn about our editorial process Print A sarcoma is a type of cancer. Sarcomas are less common than other well-known types of cancer, and there are over 70 different subtypes of sarcoma that have been described. These cancers come from connective tissue--the tissue that makes up the structure of the body. Sarcomas can develop in bone, cartilage, muscle, nerve and other types of connective tissue, and may occur throughout the body. Science Photo Library - STEVE GSCHMEISSNER / Getty Images Where Sarcomas Come From The word "sarcoma" comes from a Greek word meaning "fleshy." Sarcomas arise from mesenchymal tissue. This tissue is the precursor to the body's connective tissue. Some of the more common types of sarcoma include: Osteosarcoma (a type of bone cancer) Liposarcoma (cancer of fat tissue) Chondrosarcoma (cancer of cartilage cells) Angiosarcoma (cancer of the blood vessels) Some risk factors can make people more susceptible to developing a carcinoma. These include conditions such as Paget's disease and neurofibromatosis as well as a family history of sarcoma. In addition, exposure to radiation, such as with the treatment of another cancer, can increase the risk of developing a sarcoma. Carcinoma vs. Sarcoma Most people are more familiar with carcinomas, cancers that occur in organs such as the lung, breast, and colon. Carcinomas are cancers that develop in epithelial cells, which are the cells covering the internal organs and the outer surfaces of the body. Sarcomas are cancers that develop in mesenchymal cells, which are the cells that make up both bones and soft tissues, such as muscles, tendons, and blood vessels. One major difference between sarcomas and carcinomas is the way in which these cancers spread through the body. Sarcomas tend to spread through the blood, often to the lung. Carcinomas tend to spread through lymph fluid and blood, most frequently to nearby lymph nodes, liver, and bone, but they can also spread to the lung. As mentioned, carcinomas are much more common than sarcomas. Carcinomas represent about 90% of all cancers, and sarcomas about 1%. Sarcomas tend to occur in two distinct age groups: the very young and the elderly. Sarcomas most often grow in a ball-like shape and begin to cause pain when they press on nearby structures. One of the characteristic symptoms of a sarcoma is pain that occurs at night, often keeping people awake or awakening them from sleep. Diagnosis of a sarcoma requires obtaining a sample, called a biopsy, of the abnormal tissue. The biopsy will allow your healthcare provider to determine the type of sarcoma, as well as to learn about how aggressive the tumor appears. This information is important to help guide the most appropriate treatment. Treatment of Sarcoma The treatment of a sarcoma depends on a number of factors, including: Type of sarcomaThe grade (high grade or low grade) of the tumorIf the tumor has spread (metastasized) Sarcomas can often be treated by surgical resection of the mass, and if there has been no spread of the tumor, this can sometimes lead to the cure. In more aggressive (high-grade) tumors, or in tumors that have spread, additional treatment is typically necessary. This may include radiation treatment, chemotherapy, or both. Often, with larger tumors, treatment with chemotherapy prior to surgical resection can be an effective way to shrink the size of the tumor and make for an easier surgical treatment. Was this page helpful? Thanks for your feedback! Limiting processed foods and red meats can help ward off cancer risk. These recipes focus on antioxidant-rich foods to better protect you and your loved ones. Sign up and get your guide! Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 5 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Moffitt Cancer Center. What are the different types of sarcoma? American Cancer Society. Risk factors for soft tissue sarcomas. Cancer Research UK. What are soft tissue sarcomas? National Cancer Institute. Metastatic cancer: When cancer spreads. American Cancer Society. Cancer facts & figures 2021.