Savaysa (Edoxaban) - Oral


You should not be prescribed Savaysa (edoxaban) if you have enhanced kidney function (creatine clearance > 95 milliliters (mL) per minute). Research shows that Savaysa doesn’t work well under these circumstances. Your healthcare provider might consider an alternative medication.
If you need to stop taking Savaysa for reasons other than bleeding or completion of a course of therapy, your healthcare provider may replace it with another anticoagulant. Stopping it too early without an alternative increases the risk of blood clotting events.
Epidural or spinal hematomas may occur in people treated with Savaysa receiving anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Watch for back pain, tingling, lower limb numbness, muscle weakness, and stool or urine incontinence. Contact your healthcare provider immediately if you experience any of these.

What Is Savaysa?

Savaysa (edoxaban) is a medication that lowers the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation. It is only used for atrial fibrillation that is not caused by a heart valve problem.

Edoxaban also treats a type of blood clot called deep vein thrombosis, which can sometimes lead to blood clots in the lungs (pulmonary embolism).

Edoxaban is in a class of medications called factor Xa inhibitors. It works by blocking the activity of certain clotting substances in the blood. Savaysa is available via prescription as a tablet. 

Drug Facts

Generic Name: Edoxaban

Brand Name: Savaysa

Drug Availability: Prescription

Administration Route: Oral

Therapeutic Classification: Anticoagulant

Available Generically: No

Controlled Substance: N/A

Active Ingredient: Edoxaban tosylate

Dosage Form: Tablet

What Is Savaysa Used For?

The Food and Drug Administration (FDA) approved edoxaban to prevent strokes or blood clots in people with nonvalvular atrial fibrillation. It also treats blood clots called deep vein thrombosis, which can travel to the lungs to cause a pulmonary embolism.

How to Take Savaysa

Use this medication exactly as directed by your healthcare provider. Follow all the directions on your prescription label. Don’t take more than you are prescribed.

Savaysa can be taken with or without food. If you cannot swallow a tablet whole, crush it and mix it with 2 to 3 ounces of water or applesauce. Swallow the mixture immediately without chewing. Do not save it for later use. The medication can also be crushed and mixed with 60 to 90 milliliters (mL) of water and given immediately to individuals with a gastric tube.

Do not stop taking this medication without talking to your healthcare provider first.


Store Savaysa tablets in a tightly closed container at room temperature (between 68 F and 77 F). Keep it away from moisture and out of the reach of children and pets. When traveling by plane, transport edoxaban in your carry-on or checked baggage with its original label.

Off-Label Uses

Healthcare providers may prescribe edoxaban for off-label uses, meaning for conditions not specifically indicated by the FDA.

Off-label uses of edoxaban include:

  • Prevention of blood clots called venous thromboembolism after hip replacement surgery
  • Prevention of future blood clots in people with a history of clotting.

These are not FDA-approved uses. There is no evidence that edoxaban effectively treats or prevents these conditions. Misusing this medication without the advice of a healthcare provider can result in severe or life-threatening side effects.

How Long Does Savaysa Take to Work?

Savaysa enters the bloodstream and reaches peak concentration within one to two hours after taking a dose. Its effects last for up to 24 hours.

What Are the Side Effects of Savaysa?

This is not a complete list of side effects, and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your healthcare provider or a pharmacist. You may report side effects to the FDA at or 1-800-FDA-1088.

Common Side Effects

Common side effects of Savaysa include:

Severe Side Effects

Call your healthcare provider immediately if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects can include the following:

  • Epidural hematoma, or bleeding between the inside of the skull and the outer covering of the brain (known as the dura)
  • Spinal hematoma, or an accumulation of blood that can compress the spinal cord
  • Severe bleeding
  • Thrombocytopenia (low platelet count)
  • Angioedema (swelling underneath the skin)

Report Side Effects

Savaysa may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your healthcare provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Savaysa Should I Take?

Drug Content Provided and Reviewed by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For prevention of strokes and blood clots in patients with nonvalvular atrial fibrillation:
      • Adults—60 milligrams (mg) once a day. Your doctor may adjust your dose as needed or tolerated.
      • Children—Use and dose must be determined by your doctor.
    • For treatment of deep venous thrombosis and pulmonary embolism:
      • Adults—60 milligrams (mg) once a day. Your doctor may adjust your dose as needed or tolerated.
      • Children—Use and dose must be determined by your doctor.


A dose reduction or alternative treatment may be used in some cases. Talk to your healthcare provider if any of the following apply to you.

Pregnancy and Breastfeeding

The dangers of taking edoxaban during pregnancy are not fully known. Talk to your healthcare provider if you are pregnant or may become pregnant while taking this medication. Savaysa puts pregnant people at risk for bleeding. Using it during labor or delivery in those receiving epidural anesthesia may also result in hematomas.

Additionally, do not breastfeed if you are taking Savaysa.

Kidney Impairment

About half of edoxaban leaves the body through the kidneys. Therefore, your healthcare provider may reduce Savaysa's dose if you have an existing kidney issue. 

Liver Impairment

Savaysa leaves the body through the liver. You should not take it if you have moderate or severe liver impairment.

Low Body Weight

Those with a body weight less than or equal to 60 kilograms (kg), or about 132 pounds, may be prescribed a reduced dose.

Missed Dose 

If you miss a dose of this medication, take it on the same day unless it is too close to the time of your next dose. If it is too close to the next dose, skip the missed dose. Resume the regular dosing schedule the following day. Do not take extra to make up for the missed dose. Call your healthcare provider or pharmacist if you are unsure of what to do.

Overdose: What Happens If I Take Too Much Savaysa?

Taking too much Savaysa may increase your risk of bleeding. If you think you've overdosed, immediately contact your healthcare provider for medical guidance.

What Happens If I Take Too Much Savaysa?

If you think you or someone else may have overdosed on Savaysa, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Savaysa, call 911 immediately.


Drug Content Provided and Reviewed by IBM Micromedex®

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects.

Make sure any doctor who treats you knows that you are using this medicine. You may need to stop using this medicine for several days before having surgery, including dental procedures.

Do not suddenly stop using this medicine without asking your doctor first. You might have a higher risk of stroke after you stop using this medicine.

Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal. These may be signs of bleeding problems.

This medicine may increase the risk of forming blood clots in the spine or epidural area, which may lead to long-term or permanent paralysis. This is more likely to occur if you have an epidural catheter placed in your back, are taking NSAID or blood clotting medicine, a history of repeated epidural punctures or problems with your spine, or have had surgery on your spine. Tell your doctor right away if you have back pain, loss of bladder or bowel control, tingling, numbness, or muscle weakness, especially in your legs and feet.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

What Are the Reasons I Shouldn’t Take Savaysa?

Do not take Savysa if:

  • You are allergic to it or its components
  • You have active bleeds

What Other Medications Interact With Savaysa?

Edoxaban can interact when taken with certain other drugs. Before starting treatment, tell your healthcare provider about all your medications, including prescription and over-the-counter (OTC) vitamins or herbal supplements you take.

Watch out for these medications when taking Savaysa, as they can affect how it works in the body.

Drugs that can interact with Savaysa include:


Avoid taking rifampin at the same time as Savaysa. The combination may decrease edoxaban levels, affecting how well it works.


If you are also taking verapamil, your healthcare provider may reduce your dose of edoxaban when treating deep vein thrombosis or pulmonary embolism. No dose reduction is recommended in atrial fibrillation.

Macrolides (e.g., azithromycin, clarithromycin, erythromycin)

Edoxaban dose must be reduced in people taking macrolides. No dose reduction is recommended in atrial fibrillation, though. The combination may increase edoxaban levels, thereby increasing the risk of bleeding and other adverse effects.

Itraconazole or ketoconazole

Your dose of edoxaban may also be reduced if you take azole antifungals, such as itraconazole or ketoconazole. The combination can increase edoxaban levels and, therefore, the risk of bleeding and other adverse effects. No dose reduction is recommended in atrial fibrillation.

Anticoagulants, Antiplatelets, and SSRIs/SNRIs 

Taking anticoagulants, antiplatelet drugs, thrombolytics, and SSRIs or SNRIs with Savaysa may increase the risk of bleeding. Taking these medications at the same time long-term is not recommended for this reason.


Edoxaban should not be used when taking mifepristone for pregnancy termination due to the risk of severe or prolonged vaginal bleeding. Caution is advised when mifepristone is used for other purposes because the combination may increase edoxaban levels.

This is not a comprehensive list of medications that may affect how Savaysa works. Some medicines can increase the risk of severe side effects from edoxaban. Tell your healthcare provider or pharmacist about your current medicines, OTC drugs, or herbal products.

What Medications Are Similar?

Medications similar to Savaysa include:

  • Warfarin
  • Xarelto (rivaroxaban)
  • Clopidogrel


Warfarin is an anticoagulant medication that is available in tablet form. It reduces the formation of blood clots by inhibiting certain factors that create clots in the body. Your healthcare provider may occasionally change your dose based on your INR blood test, which measures the time for blood to clot. Savaysa doesn’t require this additional blood test.


Xarelto treats or prevents blood clots. It works like Savaysa and is available as a tablet and suspension (liquid). The suspension may be a better fit for individuals with swallowing issues. For some conditions, rivaroxaban should be taken with food. Taking this medicine with or without food may also depend on the tablet's strength.


Plavix is a medication that works by reducing platelets in the blood. It prevents strokes, blood clots, or severe heart problems in people with circulation problems or who have had a heart attack. It is available in tablet form.

Frequently Asked Questions

  • What is Savaysa used for?

    Edoxaban prevents strokes or blood clots. It also treats blood clots in the legs (deep vein thrombosis) or those that form in the lungs (pulmonary embolism).

  • How can I safely stop taking Savaysa?

    Do not stop Savaysa without talking to your healthcare provider first. Stopping this medication without an alternative replacement treatment increases the risk of stroke.

  • What if I have surgery scheduled soon?

    Inform your healthcare provider that you take Savaysa before any scheduled surgery, medical, or dental procedure. You will likely be advised to stop this medication at least 24 hours before invasive or surgical procedures because of the risk of bleeding. Savaysa can be restarted after the procedure when your healthcare provider gives you the OK. You may be given an alternative anticoagulant during or after surgery.

How Can I Stay Healthy While Taking Savaysa?

To stay healthy while taking this medication, ensure you have enough of your prescription, so you don't miss any doses. If you have trouble remembering to take your pill, consider setting up reminders using a medication adherence app or setting alarms on your smartphone.

Missing doses increases the risk of blood clots. If you miss a dose, take it as soon as possible, and resume the regular dosing schedule the following day.

While on this treatment, you may bleed more easily, bleed longer, or bruise more easily. Report any unusual bleeding immediately to your healthcare provider.

Be careful not to take more than you're prescribed. Overdosing may be dangerous as there is no treatment available to reverse edoxaban. Do not use this medicine to treat any condition your healthcare provider has not checked out. 

As with any medication, talk to your healthcare provider or a pharmacist if you have any questions.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended to replace medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

10 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  8. DailyMed. Label: warfarin sodium- warfarin tablet.

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