Joint Pain Causes and Treatment Options

Joint pain causes are many, and treatments vary depending on the cause. For a lot of people, it's due to some kind of arthritis (joint inflammation). For others, such as those with fibromyalgia or an underactive thyroid, pain occurs with no underlying damage or inflammation.

Joint pain may range from a mild ache to a severe, burning, or sharp sensation in one or several joints. In some instances, joint pain is associated with other symptoms, like joint swelling and stiffness, red and warm skin, and whole-body symptoms like fatigue, weight loss, or fever.

What causes joint pain?
 Illustration by Alexandra Gordon, Verywell

Arthritis-Related Causes

In cases of arthritis-related joint pain, inflammation and/or damage within the joint space is responsible for the pain. Several types of arthritis exist and their causes differ.


Osteoarthritis (OA) is the most common form of arthritis. OA develops as a result of the breakdown of cartilage (which serves as a cushion between the bones of a joint) often due to aging. This type of arthritis tends to affect the knees, hips, neck, lower back, and fingers.

The pain of OA—which often progresses from a sharp, intermittent pain to a constant aching—worsens with movement and eases with rest. Joint stiffness and a restricted range of motion are also characteristic of OA joint pain.

While classic OA is actually a non-inflammatory arthritis, an aggressive subtype of OA, called erosive osteoarthritis, is inflammatory. Erosive OA is most common in postmenopausal women and causes a gradual onset of joint aches, stiffness, and swelling in multiple finger joints.


Gout is a type of inflammatory arthritis that occurs in some people with high levels of uric acid in their blood. As the uric acid builds up, it may form crystals in certain joint spaces, like the big toe, ankle, or knee.

A classic gout attack refers to a sudden episode of severe, often burning joint pain that usually occurs in one joint (for example, the big toe). The joint pain of a gout attack is often extreme and associated with redness, swelling, and warmth of the joint. Without treatment, an acute flare can take anywhere from three days to two weeks to resolve on its own.

The "why" behind gout joint pain is attributed to the rapid, inflammatory response of the body's immune system as it tries to digest the unwanted and foreign crystals.


Pseudogout, also known as calcium pyrophosphate deposition disease (CPPD), is a type of inflammatory arthritis that occurs as a result of calcium crystal buildup in certain joints, most commonly the knee, wrists, shoulders, ankles, feet, and elbows.

Like gout, the pain of an acute pseudogout joint attack is sudden, severe, and associated with other symptoms like joint swelling and warmth. Unlike gout, the attacks of pseudogout may last longer before remitting.

Septic Arthritis

With septic arthritis, a joint becomes infected, most commonly with a bacteria and rarely with a fungus (for example, Candida) or mycobacteria (such as tuberculosis).

Septic arthritis tends to affect a single joint, usually the knee, ankle, wrist, or hip. The affected joint is swollen, warm, and stiff, and a fever is also present.

In most cases, septic arthritis is caused by a bacterial infection in the blood that then travels to the joint space. Less commonly, joint surgery or trauma (for example, a tick bite) may be the culprit.

Viral Arthritis

Several different viruses may cause arthritis. The most common ones include hepatitis B and C, parvovirus B19, and HIV, as well as alphaviruses (transmitted by mosquitoes) like the Chikungunya virus (CHIKV).

Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease that develops gradually over a period of weeks to months. While the disease predominantly affects the joints, early symptoms may not involve them, but instead include:

  • Fatigue
  • Muscle pain
  • Low-grade fever
  • Weight loss
  • Numbness and tingling in the hands

When the joints become affected, which is a gradual process, small joints on the same side of the body—such as those in the fingers and toes—tend to be affected first. Eventually, other joints like the wrists, elbows, hips, and neck follow suit.

The joint(s) also tend to become stiff, warm, red, and swollen. Unlike osteoarthritis, the stiffness of joint pain in RA tends to be worse in the morning (lasting for more than an hour) and improve with movement.


Spondyloarthritis is a family of inflammatory rheumatic diseases that includes four conditions.

Ankylosing Spondylitis (AS)

Ankylosing spondylitis is an axial spondyloarthropathy, meaning it mainly affects the back and neck and the sacroiliac joints (which connect the spine to the pelvis).

The joint pain of AS tends to begin in early adulthood before the age of 45, come on gradually, and improve with activity (similar to RA). Morning stiffness that lasts longer than 30 minutes is also common in AS.

Psoriatic Arthritis

Up to 30% of people with psoriasis—a chronic skin condition characterized by patches of thickened skin covered by silvery scales—have psoriatic arthritis.

It most commonly affects the end joints of the fingers and toes, causing a throbbing pain, along with stiffness and swelling. Other symptoms may include swollen fingers and toes that look like sausages, and nail problems (for example, pitted nail beds).

Interestingly, the severity of a person's psoriasis does not correlate with the severity of their arthritis. And in about 15% of people, joint pain shows up before the psoriasis appears.

Reactive Arthritis

Reactive arthritis is characterized by the development of joint pain and swelling one to six weeks after an infection in the urinary tract, genitals, or intestines.

Specific bacterial organisms linked to the development of reactive arthritis include:

Typical joints involved in reactive arthritis are the knee, ankle, and foot.

Arthritis Associated With Inflammatory Bowel Disease (IBD)

Throbbing joint pain and swelling, especially in larger joints like the knees and hips, may occur in people with inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. The arthritis tends to be more active when bowel symptoms are flaring.

Systemic Lupus Erythematosus

Joint inflammation, especially of the knees, wrists, and finger joints, is common in systemic lupus erythematosus (SLE)—a chronic, autoimmune disease that can affect nearly every organ in the body.

Like RA, the same joints on the same side of the body tend to be affected in SLE. However, unlike RA, the morning stiffness does not last as long (minutes for SLE versus over an hour for RA). The joint pain also tends to be short-lived and migratory, moving from one joint to another within a 24-hour period.

Polymyalgia Rheumatica

Polymyalgia rheumatica (PMR) is an inflammatory joint disease that causes significant muscle and joints aches and stiffness in the shoulders, neck, and hips. Joint swelling and tenderness may also occur in the wrists and fingers, although it is usually mild. The feet and ankles are never affected, and the disease almost exclusively affects people over the age of 50.

Interestingly, PMR is associated with another rheumatic condition called giant cell (temporal) arteritis, which is an inflammatory blood vessel disease that causes inflammation in the arteries of the head and scalp.

Other Systemic Rheumatic Diseases

Though it may be hard to believe, the above list is not exhaustive of all the different causes of arthritis. Other less common systemic (whole-body) illnesses may cause arthritis, a few examples being:

Non-Arthritis Causes

Numerous conditions may cause joint pain that is not related to an underlying disease or inflammatory process within the joint.


The predominant symptoms of fibromyalgia, a chronic pain condition, are widespread muscle tenderness, nerve-related pain, crippling fatigue, and cognitive dysfunction dubbed "fibro fog." Some people with this illness have joint aches and, sometimes, minor joint swelling. However, healthcare providers generally don't find any serious inflammation on physical exam or inflammatory markers via blood tests.

The pain of fibromyalgia is related to dysfunction of the nervous system and hypersensitivity in the nerves. Rather than being linked to specific areas of the body, fibromyalgia pain is more likely to move around from place to place.


Hemarthrosis occurs when you have bleeding into a joint. It may be due to a number of reasons, including trauma, a bleeding disorder like hemophilia, a postsurgical complication, or tumor growth like a synovial hemangioma.


The most common cause of hypothyroidism—an underactive thyroid gland—is Hashimoto's thyroiditis, which is when your body's immune system launches an attack on your thyroid. Hypothyroidism may cause numerous symptoms, including:

  • Fatigue
  • Weight gain
  • Constipation
  • Cold intolerance
  • Joint aches
  • Stiffness

Lyme Disease

Lyme disease is transmitted via ticks. When Lyme bacteria enter joint tissue, it can cause inflammation and a condition known as Lyme arthritis. The main symptom is swelling of one or more of the joints, including the knees,shoulder, ankle, elbow, jaw, wrist, and hip.


You may be surprised to learn that unexplained aches and pains, including joint pain, are a primary physical manifestation of depression. Other common symptoms of depression include a loss of interest in pleasurable activities, a change in appetite, sleep disturbances, difficulty concentrating, and feelings of hopelessness and/or guilt.

When to See a Healthcare Provider

New joint pain is a reason to see your healthcare provider. If you have a pain condition but are experiencing pain in a new area or a markedly different type of pain, be sure to get an appointment.

Many people with one pain condition go on to develop another. For example, it's common for someone with rheumatoid arthritis or lupus to eventually develop secondary fibromyalgia.

Seek urgent medical attention if your joint pain is severe or you have any of the following additional symptoms:

  • Fever
  • Unexplained weight loss
  • Inability to function in daily life due to your joint problem
  • Feeling ill
  • Hot or significantly swollen joint
  • Sudden numbness or burning and/or muscle weakness


A thorough medical history is often key to diagnosing the cause of your joint pain. It helps to be as detailed as possible when having this conversation with your healthcare provider.

Along with this, your healthcare provider will conduct a comprehensive physical examination and, in some cases, blood tests, imaging tests, and a joint aspiration procedure. In rare cases, a biopsy (a tissue sample) is needed.

Medical History

In order to sort out your diagnosis, your primary care healthcare provider may start by inquiring about the precise characteristics of your joint pain:

  • Where exactly does it occur?
  • How intense is the joint pain?
  • Does it occur at certain times of day? After certain activities or periods of rest?
  • What worsens or improves your joint pain?

These details can be telling and help narrow down possible diagnoses.

For example, arthritis related to gout, pseudogout, or a bacterial infection tends to affect one joint at a time, come on suddenly, and be severe. On the other hand, pain related to arthritis from a systemic disease, like a spondyloarthropathy or RA, tends to be mild and achy, come on gradually, and affect more than one joint at a time.

While the joint pain of osteoarthritis improves with rest and worsens with activity, arthritis due to a systemic connective tissue disease, like rheumatoid arthritis, is worse with rest (often in the morning) and improved with activity.

Your healthcare provider will also ask whether you have a family history of joint pain, especially since certain conditions (such as psoriatic arthritis) tend to run in families.

Be sure to tell your healthcare provider if any of the following apply to you:

  • Recent fever
  • Unusual symptoms, like fatigue or unexplained weight loss
  • Recent trauma
  • Recent surgery
  • Recent viral infection

Physical Examination

When examining your joints, your healthcare provider will press on the painful joints feeling for warmth, swelling, and tenderness (signs of inflammation). They will move your joints around to see if there is any restricted range of motion or crepitus (a popping sound heard in OA), and chart the distribution of your joint pain to determine if it's symmetric (affecting matching joints, like both knees) or asymmetric (affecting joints unevenly, like one knee but not the other).

Lastly, they'll give you a complete physical examination, looking for various clues such as:

Labs and Tests

Often, a diagnosis can be made from a medical history and physical examination alone (as in the case of OA). In some instances, though, such as when a systemic disease is suspected, testing may be necessary.

Depending on what your healthcare provider discovers during your medical history and exam, they may order various blood tests. For example, if they suspect rheumatoid arthritis, they'll test your levels of rheumatoid factor and anti-citrullinated protein antibody (anti-CCP).

Other potential blood tests include:


Imaging tests can be helpful in the diagnostic process, either by supporting or confirming a diagnosis.

For example, an X-ray may reveal osteophytes (bony growths) and joint space narrowing—both classic signs of osteoarthritis. An X-ray can also reveal subtle signs of inflammatory arthritis, like erosions (craters in the bone that occur as a result of joint damage).

Other imaging tests such as an ultrasound, magnetic resonance imaging (MRI), and a computed tomography (CT) scan may provide further information about a joint and its surrounding tissues.


A joint aspiration procedure (arthrocentesis) entails a healthcare provider, often a rheumatologist, using a needle and syringe to remove fluid from inside the synovium (lining of the joints) of a painful and/or inflamed joint. The fluid can then be examined under a microscope.

Synovial fluid analysis is useful for diagnosing conditions like gout (presence of urate crystals) and septic arthritis (presence of a high white blood cell count).

Less commonly, a rheumatologist will remove a tissue sample of the lining of the synovium. This is called a synovial biopsy and can be useful for diagnosing septic arthritis due to tuberculosis or a fungus.

In some cases, you may need to see a specialist (or more than one) to get an official diagnosis.

Differential Diagnoses

Sometimes, what is perceived as joint pain is actually due to a non-joint related condition, like tendonitis, a muscle strain, or a bone fracture. While it's rare, a bone tumor may even manifest as joint pain.

The good news is that an evaluation by a healthcare professional, along with imaging tests, can generally sort this out. For instance, an X-ray can diagnose a fracture.


Once you receive a diagnosis, you and your healthcare provider can devise a treatment plan that includes medication along with self-care strategies, physical therapy, and less commonly, surgery. What's recommend depends on the cause of your joint pain, as protocols differ.

Self-Care Strategies

A part of treating joint pain entails you taking an active role in your joint and overall health. Some self-care strategies to consider under the guidance of yourhealthcare provider include:

  • Seeing your primary care healthcare provider for vaccinations and regular health screenings (for example, for osteoporosis, cancer, and depression)
  • Educating yourself about your diagnosis
  • Engaging in daily exercise, both aerobic and strengthening
  • Eating nutritiously
  • Losing weight if overweight or obese


Several different medications are used to ease joint pain, depending on your underlying diagnosis. For example, with osteoarthritis, a number of different treatments may be used, including:

In addition to pain medications, if you have a systemic disease, you may need to take a medication that alters how your immune system works—for instance, a tumor necrosis factor (TNF) inhibitor for ankylosing spondylitis and methotrexate for rheumatoid arthritis.

If you have been diagnosed with septic arthritis, you will need to take one or more antibiotics through a vein (intravenously).

Physical Therapy

Physical therapy for joint pain focuses on maintaining joint function and range of motion, strengthening muscles surrounding the joint, and minimizing joint stiffness and pain. Depending on your condition, your physical therapist may recommend a walking aid, brace, or splint to improve your functioning.

For people with fibromyalgia, a supervised physical exercise program is especially important for minimizing muscle and joint pain and easing other symptoms, like fatigue and anxiety.

Complementary and Alternative Medicine

Several mind-body therapies have been used, often in conjunction with medication and physical therapy, to alleviate joint pain. Some of these include:

In addition, while there was some hype about taking the dietary supplements glucosamine and chondroitin (or products that contain them, like Osteo Bi-Flex) for repairing the damaged cartilage of osteoarthritis, current scientific evidence is unfortunately not so supportive of this. That said, for some people, there may be a small pain-alleviating benefit to taking these supplements.

In the end, it's best to talk with your healthcare provider about whether these are right and safe for you.


Surgery is generally reserved for advanced cases of joint pain, such as knee or hip osteoarthritis that has not responded to conservative measures. In severe cases, total joint replacement may be necessary.

Alternatives to total knee or hip replacement include knee or hip osteotomy—surgeries that entail cutting and reshaping bones to ease pressure on the joint.

While an osteotomy may delay the need for a joint replacement for several years, only young, active adults with osteoarthritis limited to one side of the knee or people with certain hip conditions are generally candidates.

A Word From Verywell

Pain is your body telling you there is something amiss. Joint pain is particularly hard to miss, but if anything serves as a reminder of the importance of seeing your healthcare provider for a proper diagnosis. The good news is that, once the cause is identified, you and your healthcare provider can address and tackle the root problem so you can feel and live your best.

Frequently Asked Questions

  • What is causing pain in my jaw?

    You may have a temporomandibular disorder (TMD). The temporomandibular joints are the two joints on either side of your face just below your ears that attach your lower jaw to your skull. There are three types of TMD, two of which directly affect the joints: internal derangement of the joint, osteoarthritis, and rheumatoid arthritis.

  • What causes pain in more than one joint at a time?

    In the case of true joint pain (arthralgia), polyarticular joint pain—pain in many joints—is caused by some type of arthritis or other inflammatory disorder. Multiple-joint pain originating outside the joints—in tendons, say, or bursa—could be due to tendonitis, bursitis, polymyalgia rheumatica, and fibromyalgia.

  • When should you see a healthcare provider for joint pain?

    If you experience these symptoms for three days in a row or several times in one month, make an appointment with your healthcare provider:

    • Pain, swelling, or stiffness in one or more joints
    • Redness, warmth, or tenderness in one or more joints
    • Decreased mobility

  • Which is better for joint pain—hot or cold?

    Cold therapy, using an ice pack, for example, is usually most effective for acute inflammation of the joints, as it reduces blood flow to the area. Heat can relieve chronic joint pain by opening blood vessels, allowing blood, oxygen, and nutrients to reach painful joints.

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