Allergic Reactions During Sexual Intercourse

While relatively rare, allergic reactions are possible during sexual intercourse. Sex allergy is likely underreported due to the private nature of the matter and the reluctance of a person to bring up the issue with their doctor.

Allergic reactions to sexual activity could also be difficult to recognize because sex involves heavy breathing, an increased heart rate, and sweating, flushing or tingling of the skin.

Therefore, mild allergic reactions during sex may go unnoticed, although more severe allergic reactions, including urticaria/angioedema, asthma symptoms, and anaphylaxis, are difficult to ignore.

Hives on a woman's stomach
Srisakorn/iStock / Getty Images

Most people would assume that these reactions could be caused by exposure to a latex condom, which probably would be the most common cause.

Other causes include allergy to seminal fluid (semen), vasomotor rhinitis caused by strong emotions related to sex, and other symptoms related to exercise as a result of sexual activity.

Latex Allergy

Latex allergy, caused by exposure to latex condoms, is probably the most common cause of allergic reactions during sex. Allergic reactions to latex could affect both the male and female coming into exposure with the latex condom.

Symptoms of latex allergy could include localized itching, burning, and rash, or could involve more severe symptoms, including urticaria/angioedema, asthma symptoms, and anaphylaxis.

Usually, these symptoms occur within seconds to minutes of latex exposure, although contact dermatitis to latex occurs many hours after latex exposure and involves itchy, blistering skin only at the site of latex exposure.

Local vaginal irritation can also occur as a result of exposure to lubricants or spermicide contained on the condoms.

The diagnosis of latex allergy can be made through the use of blood testing for the presence of IgE antibody against latex.

The treatment of latex allergy mainly is latex avoidance and thus the avoidance of latex condoms. Polyurethane condoms and SKYN non-latex condoms made from polyisoprene are other options that offer protection against both pregnancy and sexually transmitted diseases (STDs).

Non-latex condoms made of lamb intestines are widely available and are an effective birth control method, but do not protect against STDs.

Seminal Fluid Allergy

Allergic reactions to seminal fluid (semen) have been reported for decades, although they are extremely rare. Proteins contained within a man’s seminal fluid, rather than to the sperm itself, cause most of these reactions in women.

There are reports of women being allergic to only a particular man’s seminal fluid, as well as reports of women being allergic to the seminal fluid of multiple partners.

It is also possible that proteins from foods or medications (including NSAIDs and antibiotics), to which the woman is allergic, can be transmitted by the man in the seminal fluid.

Symptoms of seminal fluid allergy generally include localized vaginal itching and burning within 30 minutes of vaginal intercourse, although more severe allergic reactions, including urticaria/angioedema, asthma and anaphylaxis have been reported.

Diagnosis may involve skin testing with partner's seminal fluid at an allergist's office or a blood allergy test to human seminal plasma.

Treatment has included avoidance of exposure to the seminal fluid through the use of condoms (latex or non-latex). However, a woman can be desensitized using increasing concentrations of her partner's seminal fluid, administered intravaginally.

This treatment may be desired when pregnancy is the desired outcome. The desensitized state in the woman can be maintained through regular sexual intercourse and seminal fluid exposure at least two to three times weekly.

This should only be performed under medical direction and/or supervision, particularly in patients with history of anaphylaxis. Artificial insemination with extensively washed spermatozoa (free of HSP) may be an option for couples desiring conception.

Other Allergic-Type Reactions to Sex

There are a number of other allergic reactions that, while not specific to the sexual activity, can be experienced during sex. Most of these are related to strong emotions and exercise.

Vasomotor rhinitis is a form of ​non-allergic rhinitis that causes nasal congestion, runny nose and sneezing as a result of the stimulation of parasympathetic nerves or the dilation of blood vessels in the nasal passages. Treatment may include the use of nasal ipratropium bromide sprays one hour before sexual activity.

Other reactions during sexual activity include those related to exercise, the treatments of which are specific to the condition being experienced.

Was this page helpful?
Article Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Caminati M, Giorgis V, Palterer B, Racca F, Salvottini C, Rossi O. Allergy and Sexual Behaviours: an Update. Clin Rev Allergy Immunol. 2019;56(3):269-277. doi:10.1007/s12016-017-8618-3

  2. Kelly KJ, Sussman G. Latex Allergy: Where Are We Now and How Did We Get There? J Allergy Clin Immunol Pract. 2017;5(5):1212-1216. doi:10.1016/j.jaip.2017.05.029

  3. Shah A, Panjabi C. Human seminal plasma allergy: a review of a rare phenomenon. Clin Exp Allergy. 2004;34(6):827-38. doi:10.1111/j.1365-2222.2004.01962.x

  4. Bernstein JA. Human seminal plasma hypersensitivity: an under-recognized women's health issue. Postgrad Med. 2011;123(1):120-5. doi:10.3810/pgm.2011.01.2253

  5. Tran NP, Vickery J, Blaiss MS. Management of rhinitis: allergic and non-allergic. Allergy Asthma Immunol Res. 2011;3(3):148-56. doi:10.4168/aair.2011.3.3.148

Additional Reading