Slynd (Drospirenone) – Oral

What Is Slynd?

Slynd (drospirenone) is a progestin-only birth control pill (oral contraceptive) that prevents pregnancy by suppressing ovulation

It is available by prescription as a tablet. Each 28-day pack contains 24 white tablets (4 milligrams of drospirenone each) and four green inactive tablets.

Drug Facts

Generic Name: Drospirenone 

Brand Name: Slynd

Drug Availability: Prescription

Therapeutic Classification: Contraceptive, progestin

Available Generically: No

Controlled Substance: N/A

Administration Route: Oral

Active Ingredient: Drospirenone

Dosage Form: Tablet

What Is Slynd Used For?

The Food and Drug Administration (FDA) approved Slynd for contraception in females of reproductive potential. Slynd prevents pregnancy by stopping the egg from fully developing each month so that it can no longer accept sperm.

Slynd (Drospirenone) Drug Information - Illustration by Zoe Hansen

Verywell / Zoe Hansen

How to Take Slynd

Use this medicine exactly as directed by your healthcare provider. Follow all the directions on your medicine label and package.

Follow these instructions for taking Slynd:

  • Take one pill every day at the same time in the order directed on your blister pack. Do not skip your pills, even if you do not have sex often. If you miss pills (including starting the blister pack late), you could get pregnant. 
  • Both the white pills and the green pills should be swallowed whole. Do not cut or crush.
  • If you have vomiting or diarrhea within three to four hours of taking your pill, take a new pill (the one scheduled for the next day) from your blister pack within 12 hours of the usual time you take your dose. Continue taking all your remaining pills in order. 
  • If you have vomiting or diarrhea for more than one day, your birth control pills may not work as well. If you have sex around the time you're experiencing vomiting or having diarrhea, use an additional form of birth control.

Your healthcare provider should tell you when to start taking your birth control pill:

  • If you are not currently using a hormonal birth control method, start Slynd on the first day of your natural menstrual period.
  • If you are switching from another birth control pill, start Slynd on the same day you would start the next pack of your previous birth control method. Do not continue taking the pills from your last birth control pack once you start taking Slynd. 
  • If you are switching from a vaginal ring or transdermal patch, start taking Slynd on the day you would have inserted the next ring or applied the next patch. 
  • If you are switching from an injection method of birth control, start taking Slynd on the day you would have had your next injection.
  • If you are switching from an implant or an intrauterine device (IUD), start taking Slynd on the day of removal.

Ask your healthcare provider for any clarification you may need.

Storage

Store Slynd at room temperature of 68 degrees to 77 degrees Fahrenheit. Keep away from moisture and heat and out of the reach of children and pets. When traveling, transport the pills in your carry-on or your checked baggage with Slynd's original label attached.

Off-Label Uses

Healthcare providers may prescribe Slynd off-label for medical conditions that it was not approved to treat but for which it has proven beneficial.

Off-label uses of Slynd include:

How Long Does Slynd Take to Work?

Slynd enters the bloodstream in about two to six hours and starts to take effect. It passes from the body after a few days.

What Are the Side Effects of Slynd?

As with other medications, Slynd may cause side effects. Talk to your healthcare provider about any side effects you experience while taking this medication.

This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 800-FDA-1088.

Common Side Effects

Common side effects of Slynd can include:

Severe Side Effects

Call your healthcare provider right away if you have serious side effects. Call 911 immediately if you think you or someone else is having a medical emergency. Serious side effects can include:

  • High potassium levels in your blood (hyperkalemia): Your healthcare provider may check your potassium levels in your blood before and during treatment with Slynd. 
  • Depression: Call your healthcare provider immediately if you have any thoughts of harming yourself. 
  • Blood clots forming in blood vessels (thromboembolism)

Report Side Effects

Slynd may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Slynd Should I Take?

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The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Your doctor will ask you to begin your dose on the first day of your menstrual period (called Day 1 start). When you begin on a certain day it is important that you follow that schedule, even if you miss a dose. Do not change your schedule on your own. If the schedule that you use is not convenient, check with your doctor about changing it.

  • For oral dosage form (tablets):
    • For contraception (to prevent pregnancy):
      • Adults—One white tablet (active) taken at the same time each day for 24 days in a row followed by one green (inert) tablet once a day for the last 4 days per menstrual cycle.
      • Children—Use and dose must be determined by your doctor.

Modifications

Slynd is not approved for any female who has not yet had a menstrual period or in people who have gone through menopause. Avoid using Slynd before reproductive age. 

Tell your healthcare provider if you are pregnant or breastfeeding. Stop taking drospirenone if you become pregnant. However, Slynd may be used while breastfeeding. There are no known risks to the infant or negative effects on milk production.

Missed Dose

If you forget to take an active pill (white), take it as soon as you remember. Do not try to double up the dose. Then, take one pill daily for the rest of the pack.

If you miss two or more active pills (white) in a row, take only the last of the missed pills as soon as you remember. Do not try to double-up the dose. From the next day, take one daily for the rest of the pack (discard the other missed pills). Use backup birth control for at least seven days following the missed pills.

If you miss an inactive pill (green), skip the missed pill(s) and keep taking one inactive pill daily until the pack is empty.

Follow the instructions provided with your medicine. Ask your healthcare provider if you do not understand these instructions. Missing a pill increases your risk of becoming pregnant.

Overdose: What Happens If I Take Too Much Slynd?

Drospirenone overdose can happen when you take too much of it. Overdose may lead to symptoms like nausea, vomiting, and vaginal bleeding.

What Happens If I Overdose on Slynd?

If you think you or someone else may have overdosed on Slynd, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses, has a seizure, has trouble breathing, or can’t wake up after taking too much Slynd, call 911 immediately.

Precautions

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It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may also be needed to check for unwanted effects.

Although you are using this medicine to prevent pregnancy, you should know that using this medicine while you are pregnant could harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

If you suspect that you may be pregnant, check with your doctor right away.

You might have some light bleeding or spotting, especially during the first 3 months of using this medicine. This is usually normal and should not last long. However, if you have heavy bleeding or the bleeding lasts more than a few days in a row, call your doctor.

Check with your doctor right away if you miss a menstrual period. Missed periods may occur if you skip one or more tablets and have not taken your pills exactly as directed. If you miss two periods in a row, talk to your doctor. You might need a pregnancy test.

Do not use this medicine if you smoke cigarettes or if you are over 35 years of age. If you smoke while using birth control pills containing drospirenone, you increase your risk of having a blood clot, heart attack, or stroke. Your risk is even higher if you are over age 35, if you have diabetes, high blood pressure, high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. Keep your diabetes under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level.

Using this medicine may increase your risk of having blood clotting problems. Check with your doctor right away if you have pain in the chest, groin, or legs, especially the calves, difficulty with breathing, a sudden, severe headache, slurred speech, a sudden, a sudden loss of coordination, or vision changes while using this medicine.

This medicine may cause bone problems (eg, loss of bone mineral density). Check with your doctor right away if you have pain in the back, ribs, arms, or legs or a decrease in height.

Using this medicine may increase your risk of having cervical cancer. Talk with your doctor about this risk. Check with your doctor right away if you experience abnormal vaginal bleeding.

Check with your doctor right away if you have pain or tenderness in the stomach, dark urine, pale stools, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

You may have a higher risk of an ectopic pregnancy (occurs outside the womb) if you get pregnant while using this medicine. This can be a serious and life-threatening condition. It can also cause problems that may make it harder for you to become pregnant in the future.

This medicine may affect your blood sugar levels. Check with your doctor right away if you have increased thirst or increased urination. If you notice a change in the results of your urine or blood sugar tests, or if you have any questions, check with your doctor.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. If you or your caregiver notice any of these side effects, tell your doctor right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

What Are Reasons I Shouldn’t Take Slynd?

Avoid Slynd if you are allergic to the medication or any of its ingredients, or if you have:

  • Kidney or adrenal disease: In those with these conditions, drospirenone may increase potassium in your blood to levels that can harm the heart.
  • A history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina
  • Liver tumors, liver cancer, or liver disease
  • Abnormal vaginal bleeding that has not been examined by a healthcare provider
  • Known or suspected pregnancy

What Medications Interact With Slynd?

Watch out for these medications when taking Slynd as they can affect how it works in the body.

Antibiotic or Antifungal Medicines 

Some antibiotics or antifungal medications may increase the amount of drospirenone in the body, thereby increasing blood potassium levels.

Some examples of these medications include:

  • Biaxin (clarithromycin)
  • Nizoral (ketoconazole) 
  • Onmel, Sporanax (itraconazole) 
  • Vfend (voriconazole)

On the other hand, antibiotics like Rifadin and Rimactane (rifampin), Mycobutin (rifabutin), or Banzel (rufinamide) may lower the amount of drospirenone in the body. This can reduce the effectiveness of Slynd. If you ever must take any of these medications while using Slynd, you should use alternative contraception during and 28 days after.

Antiviral Treatments for HIV or Hepatitis C 

Some of these medications may increase the amount of drospirenone in the body, thereby increasing blood potassium levels.

Some examples of these medications include: 

  • Reyataz (atazanavir)
  • Crixivan (indinavir)
  • Victrelis (boceprevir)
  • Tybost (cobicistat)
  • Prezista (darunavir)
  • Invirase (saquinavir) 

Antivirals like Sustiva (efavirenz), Intelence (etravirine), and Lexiva (fosamprenavir) may lower the amount of drospirenone in the body and reduce how well it works If you ever have to take any of these while taking Slynd, you should use alternative birth control during and 28 days after.

Tranexamic Acid

This combination may increase the risk of blood clots.

Seizure Medicines

Seizure medications may lower the amount of drospirenone in the body, thereby diminishing its effectiveness. They may even cause irregular vaginal bleeding. If you ever have to take any of these while taking Slynd, you should use alternative contraception during and 28 days after.

Examples of seizure medications include: 

Saint-John's-Wort

Saint-John’s-wort may lower the amount of drospirenone in the body and reduce its effectiveness. It may even cause irregular bleeding. If you ever have to take any of Saint-John's-wort while taking Slynd, you should use alternative contraception during and 28 days after.

This is not a comprehensive list of all medications that may affect how Slynd works. Tell your healthcare provider about all your current medicines and supplements.

What Medications Are Similar?

Medications similar to Slynd include:

  • Camila, Errin, Jolivette, Nora-BE, Ortho Micronor (norethindrone)
  • Aygestin (norethindrone)

Camila, Errin, Jolivette, Nora-Be, Ortho Micronor (Norethindrone)

Norethindrone is a synthetic form of progesterone, a key hormone in ovulation and menstruation. Norethindrone and drospirenone are both synthetic versions of progesterone. Norethindrone is also used to prevent pregnancy. Some brands are for use only as contraception.

Others help treat endometriosis (tissue similar to from the uterine lining grows outside the uterus) or vaginal bleeding disorders. Use only the brand your healthcare provider prescribes. Norethindrone has a serious warning attached to it for smokers. Cigarette smoking increases the risk of heart attack and stroke while on this medicine.

Aygestin (Norethindrone)

This brand of norethindrone treats menstrual disorders, endometriosis, or abnormal vaginal bleeding. Not all brands of this medicine treat the same thing. Some brands are only used as contraception. Avoid medication errors by using only the brand your healthcare provider prescribes.

If taking for menstrual disorders or abnormal vaginal bleeding, you will likely take the medicine for only five to 10 days. If taking for endometriosis, you will likely take it long term for several months.

Frequently Asked Questions

  • How does Slynd prevent pregnancy?

    Slynd prevents pregnancy by inhibiting ovulation. It suppresses a key hormone in the body called luteinizing hormone.

  • What if I miss my period when using Slynd?

    You may miss periods while taking drospirenone, even when you are not pregnant. However, if you go two or more months in a row without a period or have symptoms of pregnancy, contact your healthcare provider. Also, if you miss your period after a month in which you did not use your Slynd correctly, call your healthcare provider. You may be pregnant. Stop taking Slynd if you are pregnant.

  • What if I want to become pregnant?

    Consider a visit with your healthcare provider for a prepregnancy checkup before you stop taking Slynd. After this, you may stop taking it whenever you wish.

How Can I Stay Healthy While Taking Slynd?

Your chance of pregnancy depends on how well you follow the directions for taking Slynd. The better you follow the directions, the lower your chance of getting pregnant. This is a medication you should not miss. Slynd works best when taken as directed. If you are struggling with remembering to take it, consider setting reminders on your phone.

Slynd does not protect against HIV (human immunodeficiency virus) and other sexually transmitted infections (STIs). Consistent and correct use of condoms can help prevent STIs but is not a guarantee. Abstinence is the only way to prevent STIs altogether. Ask your healthcare provider any questions you might have about the medication.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare professional. Consult your doctor before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

3 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Food and Drug Administration. Slynd label.

  2. Suvarna Y, Maity N, Kalra P, Shivamurthy MC. Comparison of efficacy of metformin and oral contraceptive combination of ethinyl estradiol and drospirenone in polycystic ovary syndrome. J Turk Ger Gynecol Assoc. 2016 Jan 12;17(1):6-9. doi: 10.5152/jtgga.2016.16129. PMID: 27026772

  3. Food and Drug Administration. Ortho Micronor label