Soolantra (Ivermectin) – Topical

What Is Soolantra?

Soolantra is a prescription-only topical 1% cream that is used for the treatment of inflammatory rosacea lesions in adults. The way Soolantra cream works (its mechanism of action) to treat rosacea lesions is unknown.

Drug Facts

Generic Name: Ivermectin

Brand Name(s): Soolantra

Drug Availability: Prescription

Therapeutic Classification: Antiparasitic

Available Generically: Yes

Controlled Substance: N/A

Administration Route: Topical

Active Ingredient: Ivermectin

Dosage Form(s): Cream

What Is Soolantra Used For?

Soolantra treats inflammatory rosacea lesions (red, inflamed areas of the skin) in adults. It's been estimated that about 415 million people have rosacea worldwide. Rosacea is believed to be less frequently reported in individuals with skin of color due to knowledge and practice gaps. Studies have shown that only around 18% of Americans with rosacea are currently being treated.

Soolantra (Ivermectin) Drug Information : A person with rosacea on the face

Verywell / Zoe Hansen

How to Take Soolantra

For Soolantra Topical Cream:

  • Wash your hands with soap and water before and after use. 
  • Soolantra is for topical use only and should only be applied to your skin. 
  • Use this medication as prescribed by your healthcare provider. 
  • Use a pea-sized amount to apply a thin layer on the affected areas of your face (forehead, chin, nose, each cheek). 
  • Do not get this medication in your eyes, lips, nose, or mouth. 
  • If you accidentally apply Soolantra to a cut or scrape on your skin, rinse off the medication right away. 


Soolantra should be stored in a closed container at room temperature (about 68–77 degrees Fahrenheit), away from heat, moisture, and direct light. Do not freeze. It's permitted to take Soolantra on short excursions out of the house in temperatures between 59 and 86 degrees.

Keep your medications out of the reach of children and pets, ideally locked in a cabinet or closet.

If you plan to travel with Soolantra, get familiar with your final destination's regulations. In general, be sure to make a copy of your Soolantra prescription. Try to keep your medication in its original container from your pharmacy with your name on the label. If you have any questions about traveling with your medicine, ask your pharmacist or healthcare provider.

Discard all unused and expired drugs, but do not pour them down the drain or in the toilet. Ask your pharmacist or healthcare provider about the best ways to dispose of this medicine. And check out drug take-back programs in your area.

How Long Does Soolantra Take to Work?

According to the manufacturer, Soolantra takes about two weeks to start working.

Off-Label Uses

Topical ivermectin has been used for treatment-resistant scabies.

What Are the Side Effects of Soolantra?

This is not a complete list of side effects and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your pharmacist or a healthcare provider. You may report side effects to the Food and Drug Administration (FDA) at or 800-FDA-1088.

Common Side Effects

For Soolantra topical cream:

  • Burning sensation
  • Skin irritation

Severe Side Effects

Call your healthcare provider right away if you notice any signs of an allergic reaction such as itching, hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, or trouble breathing. If your symptoms feel life-threatening or if you think you’re having a medical emergency please call 911.

Long-Term Side Effects

There are no known long-term side effects for these medications.

Report Side Effects

Soolantra may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Soolantra Should I Take?

Drug Content Provided and Reviewed by IBM Micromedex.

The dose of this medicine will be different for different people. Follow your healthcare provider's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your healthcare provider tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

The topical dosage form (cream) for rosacea:

  • Adults—Apply to the affected area(s) of the face once a day.
  • Children—Use and dose must be determined by your healthcare provider.


The following modifications (changes) should be kept in mind when using Soolantra:

Severe allergic reaction: Avoid using Soolantra if you have a known allergy to it or any of its ingredients. Ask your pharmacist or healthcare provider for a complete list of the ingredients if you're unsure.

Pregnancy: Not enough is known about the safety and effectiveness of Soolantra in pregnant people and on their unborn fetuses. Discuss with your healthcare provider if you plan to become pregnant or are pregnant, and to weigh the benefits and risks of using Soolantra during your pregnancy.

Breastfeeding: Soolantra may be present in breast milk. We don't know enough about the safety of Soolantra in human breast milk and nursing babies. Talk with your healthcare provider if you plan to breastfeed, to weigh the benefits and risks of taking Soolantra while nursing, and the different ways available to feed your baby.

Missed Dose

If you accidentally forgot your Soolantra dose, apply it as soon as you remember. If it's already close to your next scheduled dose, however, skip the missed dose and apply the following dose at your next scheduled dosing time. Don't double up to make up for the missed dose.

Try to find ways that work for you to help yourself remember to routinely take your medication. If you miss too many doses, Soolantra might be less effective at treating your condition.

Overdose: What Happens If I Take Too Much Soolantra?

Because Soolantra is a topical medication, the possibility of overdose is extremely rare. In the case of accidental ingestion, supportive therapy can be used. Contact poison control if this product is accidentally ingested.

If you think that you're experiencing an overdose or life-threatening symptoms, seek immediate medical attention.

What Happens If I Overdose on Soolantra?

If you think you or someone else may have overdosed on Soolantra, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Soolantra, call 911 immediately.


Drug Content Provided and Reviewed by IBM Micromedex.

  • If your skin problem does not improve within a few days of using Soolantra or if it becomes worse, check with your healthcare provider.
  • Do not use this medicine for a skin problem that has not been checked by your healthcare provider.
  • If you have any questions about this, check with your healthcare provider.

What Are Reasons I Shouldn’t Take Soolantra?

If you're allergic to Soolantra or any of its ingredients, avoid using it. Ask your pharmacist or healthcare provider for a complete list of the ingredients if you're unsure.

What Other Medications Interact With Soolantra?

There are no specific drug interactions for topical ivermectin. For more detailed information about medication interactions with Soolantra, talk with your pharmacist or healthcare provider.

And be sure to talk with your healthcare provider about any other medicines that you take or plan to take, including over-the-counter (OTC, without a prescription), nonprescription products, vitamins, herbs or plant-based medicines.

What Medications Are Similar?

The following medicines have been used to topically treat rosacea:

  • Avar (sulfacetamide/sulfur)
  • Benzoyl peroxide
  • Cleocin (clindamycin)
  • Differin (adapalene)
  • Eryc or Erythrocin (erythromycin)
  • Flagyl (metronidazole)
  • Mirvaso (brimonidine gel)
  • Nix (permethrin)
  • Retin-A or Avita (tretinoin)
  • Skinoren or Finacea (azelaic acid)
  • Silymarin (milk thistle) and methylsulfonylmethane (MSM, dimethyl sulfone)

Frequently Asked Questions

  • What is Soolantra used for?

    To treat rosacea lesions.

  • How long does Soolantra take to work?

    According to the manufacturer, Soolantra takes about two weeks to start working.

  • Is Soolantra an over-the-counter medicine?

    No. Soolantra requires a prescription for its use. You cannot find it on store shelves.

How Can I Stay Healthy While Taking Soolantra?

If you're using Soolantra to treat rosacea:

  • Do not use this medicine to treat a skin problem that your healthcare provider has not examined and prescribed it for.
  • Be sure to call your healthcare provider if your symptoms do not improve or if they get worse.
  • Wear appropriate sunscreen and other sun protection.
  • Try to avoid your rosacea triggers.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended to replace medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

5 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Food and Drug Administration. Soolantra label.

  2. Gether L, Overgaard LK, Egeberg A, Thyssen JP. Incidence and prevalence of rosacea: a systematic review and meta- analysisBr J Dermatol 2018 Feb 25. doi: 10.1111/bjd.16481. 

  3. Alexis AF, Callender VD, Baldwin HE, Desai SR, Rendon MI, Taylor SC. Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experienceJournal of the American Academy of Dermatology. 2019;80(6):1722-1729.e7.

  4. Bassi A, Piccolo V, Argenziano G, Mazzatenta C. Topical ivermectin: an off-label alternative to treat neonatal Scabies in the era of permethrin resistanceJ Eur Acad Dermatol Venereol. Published online February 21, 2022.

  5. Oge’ LK, Herbert L. Muncie J, Phillips-Savoy AR. Rosacea: diagnosis and treatmentAFP. 2015;92(3):187-196.