Staph Skin Infections and MRSA

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Staph is a shorthand way to talk about the Staphylococcus aureus bacteria, which is a common cause of skin infections. Staph can also cause other infections throughout the body. Methicillin-resistant Staphylococcus aureus (MRSA) has become a concern because it does not respond to many antibiotics used for Staph.

Skin symptoms of staph infections
Verywell / Kelly Miller

Types of Staph Skin Infections

The symptoms of a staph skin infection depend on where the infection is. The staph bacteria can cause:

  • Boils: An abscess within the skin, also called a furuncle
  • Cellulitis: A localized skin infection which can make the skin red, painful, and warm
  • Folliculitis: An infection of hair follicles
  • Impetigo: Causes blisters (bullous impetigo) or honey-colored crusted lesions on the skin
  • Paronychia: An infection of the skin folds of the nails

In addition to skin infections, staph bacteria can cause:

  • Bacteremia: A blood infection
  • Deep abscesses: A collection of pus somewhere inside the body
  • Endocarditis: An infection of the valves of the heart
  • Food poisoning: Typically from toxin-producing Staphylococcus aureus in raw milk and cheese and other high-risk foods
  • Lymphadenitis: An infection of a lymph gland, which causes it to be red, swollen, and painful
  • Lymphangitis: An infection of the lymph channels that drain to lymph glands, causing red streaks in the skin
  • Osteomyelitis: A bone infection
  • Scalded skin syndrome: Can lead to blistering skin that appears scalded and peels away
  • Septic arthritis: An infection of a joint, like the hip or knee
  • Styes: An infection of the glands on the eyelid
  • Toxic shock syndrome: Classically associated with tampon use

The Staphylococcus aureus bacteria can also less commonly cause other infections, including pneumonia, ear infections, and sinusitis.


MRSA is an acronym for methicillin-resistant Staphylococcus aureus, a type of bacteria that has become resistant to many antibiotics, including methicillin, penicillin, amoxicillin, and cephalosporins. It is routinely pronounced M.R.S.A., not MUR-SA.

Although once limited to hospitals, nursing homes, and other healthcare facilities, MRSA infections are now very common among healthy children and adults in the community. Unfortunately, some staph infections, especially invasive MRSA infections, can be deadly.

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MRSA. Jodi Jacobson / Getty Images

A pediatrician will likely suspect that an infection, such as a leg abscess, is caused by MRSA if it isn't improving with routine antibiotics. In that case, the abscess may need to be drained or your child would need to be changed to a stronger or different antibiotic to treat the infection.


Talk to your pediatrician if you think that your child might have a staph infection or if you are concerned about MRSA. The diagnosis of most skin infections is made by the pattern of symptoms and physical exam findings.

It is not usually possible to know whether the infection is caused by staph or a bacteria like group A beta-hemolytic streptococcus (Streptococcus pyogenes). In often doesn't matter, as the antibiotic prescribed will likely treat either bacteria.

To make a definitive diagnosis and to confirm that staph is the bacteria causing the infection, a culture can be done. Once a bacteria is identified in a culture, the pattern on sensitivities to antibiotics can help to tell whether or not it is actually MRSA, routine S. aureus, or another bacteria.


Antistaphylococcal antibiotics are the usual treatments for staph infections. This may include a topical antibiotic cream (Bactroban, Altabax, etc.) for simple impetigo, warm compresses, and drainage for abscesses, an oral antibiotic, or an intravenous antibiotic for more serious or persistent infections.

Commonly used oral antistaphylococcal antibiotics include the first-generation cephalosporins like Keflex (cephalexin) and cefadroxil.

As resistance to antibiotics is now common among staph bacteria, including MRSA, the first antibiotic prescribed may not work. Many of these community-acquired MRSA infections can still be treated with oral antibiotics, though, such as clindamycin and trimethoprim-sulfamethoxazole (TMP-SMX or Bactrim).

Zyvox (linezolid) is a newer antibiotic used to treat complicated skin and soft tissue infections, including MRSA, in children. It is rather expensive though and is prescribed when other antibiotics either aren't working or the staph bacteria is known to be resistant to other more commonly used antibiotics, such as Bactrim and clindamycin.

More serious and multi-drug resistant MRSA can usually be treated in the hospital with the antibiotic vancomycin and/or surgical drainage.

Although it can be uncomfortable for your child, having your pediatrician drain an abscess can be the best way to get rid of the infection.


Things to know about how staph infections and MRSA spread and may be prevented include:

  • The S. aureus bacteria commonly live on or colonizes the skin of children and adults. It is especially common to find it in the nose, which can make it easily spread as children pick their nose.
  • MRSA has become more common. It is thought that up to 2% of people are colonized with the MRSA bacteria.
  • To get rid of staph colonization, it can sometimes help to treat all family members with mupirocin (Bactroban) nasal gel twice a day for 5-7 days, have everyone take weekly Hibiclens or bleach baths, keep all wounds covered, and encourage very frequent handwashing.
  • Keep bites, scrapes, and rashes clean and covered to prevent them from getting infected by the staph bacteria.
  • Encourage kids to avoid sharing towels, razors, sports equipment, and other personal items at school and in the locker room, where spreading staph infections seems to be common.
4 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Hodille E, Rose W, Diep BA, Goutelle S, Lina G, Dumitrescu O. The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus. Clin Microbiol Rev. 2017;30(4):887-917. doi:10.1128/CMR.00120-16

  2. Hassoun A, Linden PK, Friedman B. Incidence, prevalence, and management of MRSA bacteremia across patient populations-a review of recent developments in MRSA management and treatment. Crit Care. 2017;21(1):211. doi:10.1186/s13054-017-1801-3

  3. Li J, Zhao QH, Huang KC, et al. Linezolid vs. vancomycin in treatment of methicillin-resistant staphylococcus aureus infections: A meta-analysis. Eur Rev Med Pharmacol Sci. 2017;21(17):3974-3979.

  4. Huang SS, Singh R, Mckinnell JA, et al. Decolonization to reduce postdischarge infection risk among MRSA carriers. N Engl J Med. 2019;380(7):638-650. doi:10.1056/NEJMoa1716771

Additional Reading

By Vincent Iannelli, MD
 Vincent Iannelli, MD, is a board-certified pediatrician and fellow of the American Academy of Pediatrics. Dr. Iannelli has cared for children for more than 20 years.