Stem Cell Therapy for Thyroid Issues: A New Frontier

One of the great hopes for stem cell regeneration therapy is the potential to grow healthy organs from scratch. Among these organs is the thyroid, with the goal being to re-grow thyroid tissue in those who have had it removed due to thyroid cancer and people who were born without a fully developed gland. While science is advancing—research has expanded from laboratory and animal experiments to investigations on human thyroid cells in test tubes—the use of stem cell therapy for this purpose in humans just isn't there yet.

Stem Cell Therapy for Thyroid Issues - Illustration by Dennis Madamba

Verywell / Dennis Madamba

Research in Humans

First and foremost, while research on the use of stem cell therapy for thyroid disease is an exciting prospect, there are no published studies in which stem cell therapy has been even attempted in human thyroid patients. Those studies that have been done in living beings were conducted in mice, and it's important to remember that any findings of this research cannot automatically be applied to people.

Furthermore, in studies involving human thyroid tissue in test tubes, the stimulation of cells was achieved in such a way as to raise the question of making cancerous transformations more likely if it were ever to be attempted in living people.

Some claim to treat thyroid and endocrine patients with adult stem cells called autologous mesenchymal cells, which are stem cells that are derived from the patient's own adipose (fatty) tissue. There are no published studies on this therapy's efficacy, safety, or use.

Know that any stem cell treatments you see marketed for use in humans are not approved by the U.S. Food and Drug Administration (FDA) and are highly questionable.

The Latest Research

The most interesting research involves advances in embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) technology.

ESCs, also known as pluripotent stem cells, can give rise to any type of cell in the body. They are harvested from embryos that were produced, but not implanted, during IVF procedures, and their use is controversial.

In contrast, iPSCs are pluripotent cells that have been developed using a process of reprogramming adult cells.

Follicular cells—thyroid cells that make thyroid hormone (T4 and T3)—have been produced from the ESC of mice. As indicated in the findings of a study published in the journal Cell Stem Cell in 2015, these cells not only had the ability to grow but, most importantly were also able to start making thyroid hormone within two weeks. Normal amounts of thyroid hormone were generated eight weeks after cells were transplanted into mice that did not have thyroid glands.

A Like-New Thyroid Gland?

In late 2014, investigators at Mount Sinai Hospital in New York City induced human embryonic stem cells into thyroid cells, and are exploring the possibility of creating a like-new thyroid gland in patients who have had their thyroid surgically removed. They reported their results at the 84th annual American Thyroid Association meeting.

A Word From Verywell

Potentially, being able to regrow thyroid tissue could eliminate the need for hypothyroid patients to take thyroid replacement hormone. But again, far more research is needed for this to even be considered a possibility in humans.

5 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Gaide Chevronnay HP, Janssens V, Van der Smissen P, et al. Hematopoietic stem cells transplantation can normalize thyroid function in a cystinosis mouse model. Endocrinology. 2016;157(4):1363-71. doi:10.1210/en.2015-1762

  2. Davies TF, Latif R, Minsky NC, Ma R. Clinical review: The emerging cell biology of thyroid stem cellsJ Clin Endocrinol Metab. 2011;96(9):2692–2702. doi:10.1210/jc.2011-1047

  3. Sewell W, Lin RY. Generation of thyroid follicular cells from pluripotent stem cells: potential for regenerative medicine. Front Endocrinol (Lausanne). 2014;5:96.


  4. Kurmann AA, Serra M, Hawkins F, et al. Regeneration of thyroid function by transplantation of differentiated pluripotent stem cells. Cell Stem Cell. 2015;17(5):527-42. doi:10.1016/j.stem.2015.09.004

  5. 84th Annual Meeting of the American Thyroid Association. Thyroid. 2014;24 Suppl 1:P1-A123. doi:10.1089/thy.2014.2410.abstracts

Additional Reading

By Mary Shomon
Mary Shomon is a writer and hormonal health and thyroid advocate. She is the author of "The Thyroid Diet Revolution."