Supplements for Erectile Dysfunction

Close-up of dry ginseng slices, capsules and roots
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Erectile dysfunction (ED) is a real problem but you may be reluctant to talk to your doctor about it. Ads abound for supplements claiming to treat ED. Some even say they work better than prescription drugs like Viagra (sildenafil).

But many of these claims have no scientific backing. Supplements are often unresearched or under-researched. In the U.S., they're unregulated. That makes it hard to know what's safe and effective.

This article looks at what herbal supplements do have scientific backing for ED, dosages and potential side effects, and what supplements aren't supported by research.


6 Lifestyle Changes to Treat Erectile Dysfunction

ED Supplement Research

A 2020 review published in the International Journal of Impotence Research (IJIR) looked at evidence behind popular over-the-counter (OTC) supplements for ED and boosting testosterone.

  • No evidence behind them
  • Evidence that showed they didn't work
  • Studies that contradicted each other

But research has turned up some ED supplements that appear to be safe and effective. They include:

  • Ginseng and vitamin E
  • L-arginine
  • Pycnogenol
  • Yohimbe/yohimbine
  • Tribulus terrestris
  • Eurycoma longifolia (tongkat ali)

Ginseng and Vitamin E

Panax ginseng is one of the better researched ED supplements.

A small clinical trial from 2021 looked at the effectiveness of ginseng combined with vitamin E for ED. Both supplements are antioxidants, which have been shown to help with blood flow and erectile function.

Researchers said the supplements improved erectile function significantly more than placebo after six weeks of use. Side effects appeared similar to the placebo group.

While this was a double-blind, placebo-controlled, randomized clinical trial—the best type of research—the authors called for larger and longer trials.

A 2018 meta-analysis, which looked at 24 clinical trials, found evidence behind ginseng "encouraging." A 2021 review in the Arab Journal of Urology listed it first among promising herbal remedies.


Daily dosages in the clinical trial were:

  • 107 milligrams (mg) of ginseng
  • 100 IU vitamin E

Dosages of ginseng aren't well established.

The recommended daily allowance (RDA) of vitamin E for adults is 15 mg, well below the ED dosage in studies.

Talk to your doctor before taking these or any supplement. Don't take more than the amount specified by your doctor or on the product label.

Side Effects

Common side effects of ginseng include:

  • Nervousness
  • Insomnia
  • Increased blood pressure
  • Breast pain
  • Vomiting
  • Diarrhea
  • Mania

More serious but rare side effects may be:

  • Inflammation of arteries in the brain
  • Inflammation of the liver
  • Severe skin reactions
  • Allergic reactions, including anaphylaxis

Vitamin E side effects, especially at high doses, are:

But research has turned up some supplements that appear to be safe and effective for ED. They include:

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhea

Researchers gave 68% of them a C or D grade. They say those products either had:

Supplement Warnings

Natural doesn't always mean safe. Supplements can cause side effects, including some potentially dangerous or deadly ones. They may also interact negatively with other things you take. Involve your doctor and pharmacist in your decisions about a supplement regimen.


L-arginine, also called simply arginine, is a vasodilator, meaning it opens blood vessels. That's the same mechanism of action as ED medications.

The Arab Journal review said L-arginine was promising and warranted further study.

A 2019 meta-analysis of L-arginine for ED found enough credible evidence to recommend it for mild to moderate erectile dysfunction.

Researchers said it significantly improved:

  • Erectile function
  • Orgasmic function
  • Intercourse satisfaction
  • Overall satisfaction

They side side effects were rare, experienced by just 8.3% of participants. None was severe.


Standard dosages of L-arginine haven't been established. Doses in studies ranged from 1,500 mg to 5,000 mg. This is lower than what's been studied for other conditions, including high blood pressure.

You can get L-arginine through your diet. It's in:

  • Red meat
  • Poultry
  • Fish
  • Dairy products

Talk to your doctor about whether L-arginine is right for you and at what dosage. Don't take more than recommended amounts on the product label or what your doctor suggests.

Side Effects

Side effects of L-arginine include:

  • Abdominal pain
  • Bloating
  • Diarrhea
  • Gout
  • Allergies
  • Worsened asthma
  • Low blood pressure


Pycnogenol is another supplement called "promising" by the Arab review. This bark-based product is an antioxidant. It's believed to improve circulation and athletic performance.

However, in a 2020 meta-analysis, researchers concluded there's not enough evidence to say whether it improves erectile function.

A significantly older clinical trial, published in 2003, suggested a three-month course of Pycnogenol plus L-arginine restored sexual function.

Pycnogenol is a trademarked name for a patented form of French maritime pine bark extract. It's also called pygnogenol, maritime pine, or pine bark extract.


Pycnogelol is considered "possibly safe" in daily doses between 50 mg and 450 mg for up to a year of use.

You can get similar compounds through your diet. They're naturally in:

  • Grapes
  • Red wine
  • Blueberries, cranberries, strawberries, bilberries
  • Red cabbage
  • Apple peel
  • Ginkgo biloba

Side Effects

Possible side effects of Pycnogenol include:

  • Dizziness
  • Stomach upset
  • Headache
  • Mouth sores
  • Bad breath

Pycnogenol may make autoimmune diseases worse by stimulating the immune system. It may also slow blood clotting and lower blood sugar to dangerous levels.


Yohimbe or yohimbine is among the most common supplements marketed for ED. It's sometimes called johimbe. It's also considered an aphrodisiac, meaning it increases sexual desire.

Yohimbe is the name of an African tree. Its bark contains the chemical yohimbine, which is used medicinally. It's marketed under both names but is essentially the same product.

Yohimbe blocks the action of cellular structures called alpha-2 adrenergic receptors. When activated, these receptors prevent you from having an erection.

So blocking the receptors basically removes a roadblock. It may also increase blood flow to the penis by widening blood vessels.

In studies, it's had a consistent but limited effect on ED.

Prescription Form

In the U.S., a form of yohimbine (yohimbine hydrochloride) is used in a prescription drug. It's sold as Aphrodyne and Yocon and marketed for impotence and as an aphrodisiac. However, this product is believed to work differently from yohimbe supplements.


Dosages for yohimine aren't established. The usual recommended dose of yohimbine is between 5 mg and 10 mg, three times a day.

According to the National Center for Complementary and Integrative Health, some products labeled as yohimbe contain very little yohimbine. Many don't include amounts on the label, either. That can make it hard for you to know how much you're getting.

Be certain you talk to your healthcare provider before taking yohimbe supplements and don't take more than suggested.

Side Effects

Studies have documented several negative reactions to yohimbe. Possible side effects include:

  • Insomnia
  • Anxiety
  • Fast or irregular heartbeat
  • Chest pain
  • Sweating
  • Blurred vision
  • High blood pressure (hypertension)

Overdose is possible with yohimbe. It can cause:

  • Low blood pressure (hypotension)
  • Rapid heartbeat
  • Seizures
  • Paralysis
  • Coma
  • Death

Tribulus Terrestris

The IJIR study gave Tribulus terrestris an A grade. The Arab review said it had promising evidence and was among the better-studied options (along with ginseng, L-arginine, and Pycnogenol).

Tribulus is an herb from the subtropical regions of Asia, Africa, and southern Europe. It contains saponins, a type of antioxidant that strengthens small blood vessels (capillaries) in the skin. That's believed to be how it works for ED.

A small clinical trial in 2018 focused on aging men with partial androgen (male hormone) deficiency. Researchers said Tribulus had a "robust effect" in raising testosterone and improving sexual function in ED.

A larger 2017 clinical trial found the supplement significantly improved:

  • Erections
  • Intercourse satisfaction
  • Orgasmic function
  • Sexual desire
  • Overall satisfaction

Researchers said it was generally well-tolerated.


A standardized form of Tribulus is sold under the name Tribestan. It comes in 250-mg tablets.

The package recommends taking one or two tablets 3 times a day for at least 90 days. Never take more than the recommended amount.

Check with your doctor on whether this product is safe for you and at what dosage.

Side Effects

The primary reported side effect of Tribulus is stomach irritation. In rare cases, it may cause:

  • Severe liver and kidney problems
  • Neurological toxicity
  • Priapism (a prolonged and painful erection)

Eurycoma Longifolia

Eurycoma longifolia, sometimes called tongkat ali or longjack, also received an A from the IJIR study. It comes from the roots of a Southeast Asian shrub and contains several antioxidants.

Long used in traditional medicine for enhancing virility, research suggests it has the same mechanism of action as the ED drugs Viagra, Cialis (tadalafil), and Levitra (vardenafil) and other possible effects beneficial in ED.


Some studies have reported success with between 200 mg and 300 mg per day of Eurycoma longifolia. One review notes recommendations of up to 400 mg.

However, safe and effective doses aren't established. Little is known about long-term safety. Follow packaging instructions or ask your healthcare provider about the best dosage for you.

Side Effects

So far, studies have not noted any side effects of Eurycoma longifolia. However, because it may raise testosterone levels, it may not be safe for people with:

  • Heart disease
  • Hormone-sensitive cancers
  • Liver disease
  • Kidney disease
  • Sleep apnea

Other Promising Supplements

Several other supplements have been researched but have less evidence overall or mixed results. These include:

Supplements That Don't Work 

Supplements for ED are among the better researched ones. So, if research hasn't shown promising results or if there's no research, you probably shouldn't bother with it.

The IJIR study that assigned letter grades gave these common supplements a C:

  • Aspartate
  • Boron
  • Fenugreek
  • L-citrulline
  • Vaca root
  • Zinc

They gave D grades to:

  • Cayenne pepper
  • Diindolymethane (DIM)
  • Magnesium
  • Nettle leaf
  • Sarsaparilla extract
  • Vitamin B6

Two popular herbs that aren't proven and may be risky to use are:

  • Ginkgo: May increase risk of excessive bleeding
  • Horny goad week (epimedium): May have a negative impact on your heart or breathing

The Placebo Effect

In placebo-controlled clinical trials of Viagra, 30% of participants taking the placebo reported better erections. People taking herbal supplements for ED may experience a similar effect and lead them to believe the supplement works. That means, even if your friend swears by it, that's not proof of effectiveness.


ED supplements research suggests are generally safe and effective include:

  • Ginseng and vitamin E
  • L-arginine
  • Pycnogenol
  • Yohimbe/yohimbine
  • Tribulus terrestris
  • Eurycoma longifolia (tongkat ali)

Even so, they can cause side effects and interact negatively with drugs. They may not be safe for everyone. Be sure to ask your healthcare provider what's right for you.

Other supplements with promise are:

  • Macurna pruriens (velvet bean)
  • P. pinaster
  • L. meyenii
  • DHEA

Many more have inadequate research, negative results, or mixed results. Some, including ginkgo and horny goat weed, may be dangerous.

A Word From Verywell

Erectile dysfunction can have a very real impact on your life, mental health, and relationships. Supplements may be a good treatment option, instead of or alongside prescription medications.

Even if you opt for supplements alone, be sure to talk to your healthcare provider about what's safest and most likely to work for you. Your doctor can help you consider your overall health, other conditions, and all the medications you're on.

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Article Sources
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  1. Najafabadi BT, Jafarinia M, Ghamari K, et al. Vitamin E and ginseng combined supplement for treatment of male erectile dysfunction: A double-blind, placebo-controlled, randomized, clinical trial. Adv in Int Med. Mar 2021;8(1):44-49. doi:10.1016/j.aimed.2019.12.001

  2. Leisegang K, Finelli R. Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review. Arab J Urology. Published online ahead of print: June 2021. doi:10.1080/2090598X.2021.1926753

  3. Kuchakulla M, Narasimman M, Soni Y, Leong JY, Patel P, Ramasamy R. A systematic review and evidence-based analysis of ingredients in popular male testosterone and erectile dysfunction supplementsInt J Impot Res. 2021;33(3):311-317. doi:10.1038/s41443-020-0285-x

  4. International Society for Sexual Medicine. Flavonoids associated with improved erectile function. Updated March 5, 2018.

  5. Borrelli F, Colalto C, Delfino DV, Iriti M, Izzo AA. Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysisDrugs. 2018;78(6):643-673. doi:10.1007/s40265-018-0897-3

  6. The National Capital Poison Center. Side effects of ginseng supplements. Updated February 27, 2019.

  7. National Library of Medicine. National Center for Biotechnology Information. Vitamin E Compound Summary. Updated May 16, 2020.

  8. Cziráki A, Lenkey Z, Sulyok E, Szokodi I, Koller A. L-arginine-nitric oxide-asymmetric dimethylarginine pathway and the coronary circulation: Translation of basic science results to clinical practiceFront Pharmacol. 2020;11:569914. Published 2020 Sep 29. doi:10.3389/fphar.2020.569914

  9. Rhim HC, Kim MS, Park YJ, et al. The potential role of arginine supplements on erectile dysfunction: A systemic review and meta-analysis [published correction appears in J Sex Med. 2020 Mar;17(3):560]. J Sex Med. 2019;16(2):223-234. doi:10.1016/j.jsxm.2018.12.002

  10. National Institutes of Health, U.S. National Library of Medicine: MedlinePlus. L-arginine. Updated June 29, 2021.

  11. National Institutes of Health, U.S. National Library of Medicine: MedlinePlus. Maritime pine. Updated June 29, 2021.

  12. Robertson NU, Schoonees A, Brand A, Visser J. Pine bark (Pinus spp.) extract for treating chronic disordersCochrane Database Syst Rev. 2020;9(9):CD008294. Published 2020 Sep 29. doi:10.1002/14651858.CD008294.pub5

  13. Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-arginineJ Sex Marital Ther. 2003;29(3):207-213. doi:10.1080/00926230390155104

  14. University of Rochester Medical Center. Proanthocyanidins.

  15. Yohimbine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; April 5, 2020.

  16. National Institutes of Health, National Center for Complementary and Integrative Health. Yohimbe. Updated November 2020.

  17. Gamal El Din SF, Abdel Salam MA, Mohamed MS, et al. Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled studyUrologia. 2019;86(2):74-78. doi:10.1177/0391560318802160

  18. Ezzat SM, El Bishbishy MH, El Kersh DM, et al. Chapter 7 - Herbal cosmeticology. In: Egbuna C, Mishra AP, Goyal MR. Preparation of phytopharmaceuticals for the management of disorders: The development of nutraceuticals and traditional medicine. Cambridge, Mass.: Academic Press; 2020.

  19. Kamenov Z, Fileva S, Kalinov K, Jannini EA. Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trialMaturitas. 2017;99:20-26. doi:10.1016/j.maturitas.2017.01.011

  20. Memorial Sloan Kettering Cancer Center. Tribulus terrestris. Updated May 5, 2020.

  21. Oboh G, Adebayo AA, Ademosun AO. Phenolic-rich extracts of Eurycoma longifolia and Cylicodiscus gabunensis inhibit enzymes responsible for the development of erectile dysfunction and are antioxidantsJ Basic Clin Physiol Pharmacol. 2018;29(6):689-696. doi:10.1515/jbcpp-2017-0160

  22. Ezzat SM, Okba MM, Ezzat MI, Aborehab NM, Mohamed SO. Rho-kinase II inhibitory potential of Eurycoma longifolia new isolate for the management of erectile dysfunctionEvid Based Complement Alternat Med. 2019;2019:4341592. Published 2019 May 15. doi:10.1155/2019/4341592

  23. Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertilityAsian J Androl. 2010;12(3):376-380. doi:10.1038/aja.2010.7

  24. Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized clinical trial on the use of PHYSTA freeze-dried water extract of Eurycoma longifolia for the improvement of quality of life and sexual well-being in menEvid Based Complement Alternat Med. 2012;2012:429268. doi:10.1155/2012/429268

  25. Rehman SU, Choe K, Yoo HH. Review on a traditional herbal medicine, eurycoma longifolia jack (Tongkat ali): Its traditional uses, chemistry, evidence-based pharmacology and toxicologyMolecules. 2016;21(3):331. doi:10.3390/molecules21030331

  26. Henkel RR, Wang R, Bassett SH, et al. Tongkat Ali as a potential herbal supplement for physically active male and female seniors--a pilot studyPhytother Res. 2014;28(4):544-550. doi:10.1002/ptr.5017

  27. Edwards S, Rocha I, Williamson EM, Heinrich M. Phytopharmacy – an evidence-based guide to herbal medicines. Chichester: Wiley; 2015.

  28. El-Sakka AI. Dehydroepiandrosterone and erectile function: A reviewWorld J Mens Health. 2018;36(3):183-191. doi:10.5534/wjmh.180005

  29. National Capital Poison Center. Ginkgo biloba. Updated February 26, 2018.

  30. National Institutes of Health, U.S. National Library of Medicine: MedlinePLus. Horny goat weed.

  31. Tignol J, Furlan PM, Gomez-beneyto M, et al. Efficacy of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in remission from depression. Int Clin Psychopharmacol. 2004;19(4):191-9.