Synvisc Injections for Delaying Knee Surgery

Synvisc (Hylan G-F 20) is a viscous fluid derived from a substance known as hyaluronan (sodium hyaluronate). Hyaluronan is produced naturally in the body to help lubricate the joints. The form of hyaluronan found in Synvisc is made from gelatinous substances derived from chicken combs.

Synvisc is used in a form of therapy known as viscosupplementation in which the substance is injected into joint spaces to help increase lubrication.

This article discusses Synvisc knee injections, the procedure, and the side effects of Synvisc. It also discusses Synvisc injection dosage and costs.

Synvisc Injection Overview

Synvisc injection procedures are approved for the treatment of osteoarthritis of the knee in people who have failed to respond to more conservative therapy, including analgesics and non-drug options.

Synvisc is delivered in a 2-milliliter injection directly into the knee joint. It has not yet been approved for any joint other than the knee. Synvisc is typically given as a series of three injections delivered weekly. To achieve the best results, synovial fluids in the cavity of the knee are typically removed before the first injection.

Another Synvisc product, known as Synvisc-One, is administered as a single, 6-milliliter shot.

Synvisc was approved for use by the U.S. Food and Drug Administration on August 8, 1997. Synvisc-One received its FDA approval on February 26, 2009.

Knee Injection Synvisc Side Effects

The most common side effects associated with Synvisc include:

• Pain, swelling, or stiffness in the injected knee
• Joint effusion ("water in the knee")
• Joint nerve pain
• Rash or hives
• Fever
• Nausea
• Headache
• Dizziness
• Muscle cramps
• Fatigue

Most of these symptoms are mild to moderate in severity and will resolve on their own without treatment. If any of the symptoms persist or worsen, call your healthcare provider immediately as this may be a sign of an infection or allergy.

The Effectiveness of Synvisc in Delaying Knee Surgery

Several studies have been done to assess whether hyaluronic acid injections are successful in delaying knee replacement surgery.

One study using a database of 182,022 patients who received a total knee replacement (TKR) surgery found that the injections were associated with delaying the need for the surgery.

Those who did not get the injections had the surgery within 0.7 years, those with one course of injections had the surgery in 1.4 years, while those with five courses of treatment delayed the surgery by 3.6 years. Similar results have been found in other large follow-up studies.

Osteoarthritis of the knee is today the most common type of arthritis in the United States, affecting an estimated 13.7 million people. Based on the study findings, Synvisc is considered to be a safe and effective means of treating pain and disability in this population and, when used appropriately, may help delay surgery for three years or more.