Symptoms of Syphilis

The signs and symptoms of syphilis vary based on the stage of the infection. There are four stages in all, each with distinct features. Some symptoms are "classic," meaning clear signs of the disease, while others are non-specific and easily confused for other conditions.

Because syphilis mimics symptoms of other conditions, such as canker sores, herpes, and Lyme disease, it is often referred to as the "great imitator." This accounts for why many cases are missed until the disease is advanced and symptoms turn severe.

This article lists the symptoms of each stage of this sexually transmitted infection (STI) as well as the signs and complications in children born with syphilis.

Syphilis symptoms

Verywell / Joshua Seong

Primary Syphilis

Primary syphilis is the first stage that occurs soon after exposure to Treponema pallidum, the bacteria that cause the condition. The classic sign is a painless skin ulcer, called a chancre, that appears at the point of sexual contact, most often the cervix, vaginapenis, anus, rectum, or mouth. This can show up 10 to 90 days after exposure, though the average is 21 days.

There may be one or more lesions ranging in size from an eighth of an inch to an inch or more. Because the sores are painless, they can be missed if they are inside the rectum or vagina.

Lymph nodes nearest the chancre may also be swollen. This is a sign that the body is fighting the infection. Without treatment, a chancre will heal within three to six weeks.

Chancre Sores

The classic sign of primary syphilis is a skin ulcer, called a chancre, that typically appears on the genitals, anus, rectum, or mouth. Without treatment, the sore will heal in three to six weeks.

Secondary Syphilis

If left untreated, primary syphilis will progress to secondary syphilis. Symptoms most often appear within four to 10 weeks after the primary infection.

Secondary syphilis typically starts with a non-itchy rash on one or more parts of the body. This rash can start while the chancre is still healing or after it has healed. A classic sign is the appearance of red or reddish-brown spots on the palms of the hands and soles of the feet.

The rash on other parts of the body can vary in appearance—ranging from hives to pus-filled blisters—or be so faint that you can hardly see it. There may even be whitish, wart-like lesions, called condyloma lata, on moist parts of the body like the groin or armpits.

This photo contains content that some people may find graphic or disturbing.

A syphillis rash on hands

Reproduced with permission from © DermNet New Zealand and © Dr. Richard Ashton 2023.

Another telltale sign is unexplained hair loss, referred to as syphilitic alopecia.

During this stage of infection, other symptoms may include:

  • Fever
  • Sore throat
  • Swollen lymph nodes
  • Fatigue
  • Weight loss
  • Headache
  • Joint pain
  • Muscle ache

The symptoms usually resolve without treatment within weeks or months. Studies have shown that 40% to 85% of people with vaginas and 20% to 65% of people with penises who have secondary syphilis do not recall having a chancre.

Secondary Syphilis

Secondary syphilis typically starts with a rash on one or more parts of the body. The rash can vary from person to person, but a "classic" sign is the appearance of red to reddish-brown spots on both the palms of the hands and soles of the feet.

Latent Syphilis

Latent syphilis is the third stage of infection. This "hidden" stage is noted for having few or no signs or symptoms.

The latent stage is further divided into two sub-stages:

  • Early latent syphilis is the period within 12 months of the initial infection. As many as 1 in 4 people will experience a relapse of secondary syphilis during this stage.
  • Late latent syphilis is when the infection occurred more than 12 months ago. This stage can last for years and even decades with no signs of disease.

While syphilis can be passed to another person during the early latent stage, it is less likely to be passed during the late latent stage.

Tertiary Syphilis

Tertiary syphilis is the most serious stage, as it can affect multiple organs. It tends to start 10 to 30 years after you have been infected and can be fatal. Between 15% and 40% who don't get treatment will develop tertiary syphilis.

While syphilis can still be treated during the tertiary stage, any damage caused to the heart, kidneys, and other major organs may be permanent and can lead to end-stage organ failure.

There are three major complications of tertiary syphilis:

Gummatous Syphilis

Gummatous syphilis is a complication in which soft, tumor-like lesions (called gummas) form on the skin, bones, liver, heart, muscles, and other parts of the body. The gummas are caused by an inflammatory reaction and contain a mass of dead and swollen fiber-like tissues.

Gummas can grow to a considerable size, causing major damage to organs. It can also cause open sores on the skin and mouth that resemble tuberculosis.

Cardiovascular Syphilis

Cardiovascular syphilis is a complication that affects the heart and blood vessels. It causes severe inflammation of the aorta, the main vessel that carries blood from the heart, causing it to swell and weaken. This can result in an aortic aneurysm in which the aorta bulges to a point where it can spontaneously burst.


Neurosyphilis affects the central nervous system. While some people will not have any symptoms of neurosyphilis, others may develop serious issues such as:

  • General paresis: Also known as paralytic dementia
  • Meningitis: Inflammation of the membrane surrounding the brain and spinal cord
  • Tabes dorsalis: Caused by the destruction of nerves in the spinal cord

Seizures, personality changes, hallucinations, dementia, and stroke are among the possible symptoms of neurosyphilis.

Tertiary Syphilis

Tertiary syphilis is the most advanced stage of the disease and one that can affect the heart, skin, bones, brain, and other organ systems. While the infection can still be treated, any damage to major organs may be permanent and lead to organ failure and death.

Complications in Newborns

Congenital syphilis is a serious condition in which a pregnant person with syphilis passes the infection to the developing fetus.

As many as two-thirds of babies born with syphilis will not have symptoms during the first two years of life. Of those who do, symptoms may include:

By age 2, the child may start to develop physical deformities and other severe complications if not treated. This may include:

  • Blunted upper front teeth (known as Hutchinson's teeth)
  • The collapse of the nasal bone (referred to as saddle nose)
  • A protruding jawbone and foreshortened upper jaw
  • A protruding forehead (known as frontal bossing)
  • Bowing of the shin bones (referred to as saber shins)
  • Swollen knees
  • Interstitial keratitis (loss of clearness of the cornea of the eye)
  • Glaucoma (caused by damage to the optic nerve)
  • Deafness
  • Developmental delays

Syphilis in Children

Most children with congenital syphilis will not have symptoms for the first two years of life. After age 2, the child may start to develop physical deformities, impaired vision and hearing, and developmental delays if not treated.


The signs and symptoms of syphilis vary by stage. Primary syphilis occurs soon after infection and usually causes one or more sores (called chancres) on the genitals, anus, rectum, or mouth.

This is followed by secondary syphilis, in which there is a rash on one or more parts of the body, followed by the latency stage, which can last for years with no symptoms.

The most advanced stage is tertiary syphilis, which can affect multiple organs, including the skin, heart, brain, bones, and liver. While syphilis can still be treated at this stage, there is an increased risk of permanent organ damage and organ failure.

Children born with congenital syphilis may not have any symptoms at first but then start to develop physical deformities, impaired hearing and vision, and developmental delays if not treated.

A Word From Verywell

Because syphilis symptoms can be missed, you need to take action if there is a chance you may have been infected. If you have ever been at risk of exposure—either because of condomless sex or having multiple sex partners—you should consider getting an STI test whether you've ever had symptoms or not.

For some key populations, such as men who have sex with men (MSM) and people living with HIV, syphilis screening may be advised every three months rather than annually.

Frequently Asked Questions

  • Is syphilis curable?

    Yes, syphilis can be treated and cured with antibiotics. However, associated damage to some parts of your body, such as your kidneys, may not be reversible.

  • In which stage is syphilis contagious and not contagious?

    Syphilis is known to be contagious during the primary, secondary, and early part of the latent stages. It is less contagious during the latter part of the latent stage or when in relapse. Still, it's best to get treated and avoid sexual activity until you are given clearance by your doctor.

11 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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By Mark Cichocki, RN
Mark Cichocki, RN, is an HIV/AIDS nurse educator at the University of Michigan Health System for more than 20 years.