Technivie - Hepatitis C Drug Information

Courtesy AbbVie

Technivie (ombitasvir + paritaprevir + ritonavir) is fixed-dose combination drug used in the treatment of chronic hepatitis C (HCV) infection. The three agents that comprise Technivie are also bundled in the two-pill HCV therapy, Viekira Pak.

Technivie was approved on July 24, 2015 by the U.S. Food and Drug Administration (FDA) for use in adults 18 years or over with HCV genotype 4 infection (GT4) without cirrhosis.

Technivie is the first, all-oral, interferon-free HCV therapy for patients GT4 chronic HCV infection, a population traditionally considered difficult to treat.

Technivie was reported to have a cure rate of 100% of previously untreated ("treatment naïve") patients in a Phase IIb trial conducted from August 12, 2012 to November 19, 2013.


Two tablets (12.5mg ombitasvir, 75mg paritaprevir, 50mg ritonavir) taken daily with a meal without the need for high fat or caloric intake. Technivie tablets are pink, oblong and film-coated, with "AV1" embossed on one side.

Prescribing Recommendations

Technivie is prescribed over a 12-week course along with ribavirin (a drug used to inhibit viral RNA synthesis). The recommended dose of ribavirin is based on weight, as follows:

  • Less than 165 lbs (75kg): 1000mg daily, divided and administered twice daily with food
  • 165 lbs (75kg) and over: 1250mg daily, divided and administered twice daily with food

A 12-week course of Technivie can be considered for treatment naïve patient who is unable to tolerate ribavirin.

Common Side Effects

The most common side effects associated with the use of Technivie (occurring in at least 7% of patients) are:

  • Physical weakness
  • Fatigue
  • Nausea
  • Insomnia
  • Rash

Contraindicated Medications

The following drugs should also be not be taken when using Technivie:

  • Anticonvulsants: Tegretol, Dilantin, Trileptal, phenobarbital
  • Antipsychotics: Orap
  • Antiretroviral medication: Sustiva
  • Cholesterol-lowering statin drugs: Altoprev, Mevacor, Zocor
  • Erectile dysfunction medication: Revatio
  • Ergot derivatives (used in the treatment of headaches): DHE 45, Ergomar, Ergotrate, Hydergine, Migranal
  • Estinyl estradiol-containing contraceptives: Estinyl, Apri, Reclipsen, Azurette, Kariva, Yaz, Yasmin, Ocella, Vestura, Beyaz, Safyral, Zovia, Demulen, Demulen 1/35, Kelnor 1/35, Nuva Ring, FaLessa, Lutera, Alesse, Seasonique, Aviane, Ortho Evra, Xulane, Lo Loestrin Fe, Necon 1/35, Minastrin 24 Fe, Loestrin 24 Fe, Ortho Tri-Cyclen, Sprintec, Ortho Tri-Cyclen Lo, Tri-Sprintec, Cryselle, Lo/Ovral, Ovral, Elinest
  • Rifampin-based anti-tuberculosis medications: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
  • Sedatives: Versed, Halcion
  • St. John's Wort

Contraindications and Considerations

Technivie is not recommended for patients with moderate hepatic impairment (Child-Pugh score B) and is contraindicated in patients with severe hepatic impairment (Child-Pugh score C).

Technivie is contraindicated for use in patients with known hypersensitivity to ritonavir (i.e., who have experienced Stevens-Johnson Syndrome or toxic epidermal necrolysis).  

While Technivie on its own is not contraindicated for use in pregnancy, the combination of Technivie and ribavirin is and should not be used either in pregnant women or men whose female partners are pregnant. In terms of breastfeeding, there were no incidences of abnormal fetal development note in animal studies; specialist consultation is recommended to discuss potential benefits and adverse effects of breastfeeding while on Technivie.

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