30 Most Commonly Prescribed Pediatric Medications

Most Prescribed Drugs for Kids and Teens

This list of the most prescribed drugs for children and teens can help you understand the medicines your kids might be prescribed by your pediatrician. It comes from analysis of a large prescription database over the course of eight years. Antibiotics top the list, although their use declined during the eight years of the study.

Other than the fact that there are no drops for pink eye, such as Polytrim, Vigamox, or Moxeza, this list is about what you would expect from the average pediatrician. Ideally, you would see many fewer scripts for narcotic pain relievers and more scripts for combination inhalers to help control asthma, such as Advair, Dulera, and Symbicort.



Boy holding red pills and glass of water

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It shouldn't be surprising that this antibiotic is the most commonly prescribed medication for children. Amoxil (amoxicillin) is very inexpensive as a generic drug and is generally well tolerated.

It can treat strep throat as well as childhood pneumonia, ear infections, and sinus infections, especially when used at high-dose levels.



Another antibiotic, Zithromax (azithromycin) is also available as a generic. It is often prescribed for ear infections.



The first drug on the list that isn't an antibiotic, albuterol is a bronchodilator that is used to relieve asthma symptoms. It is available in a form for a nebulizer and as a metered dose inhaler (ProAir HFA, Proventil HFA, Ventolin HFA, etc.). The syrup form of albuterol is very rarely used by most pediatricians.

Albuterol nebulizer solution is an inexpensive medication. Albuterol asthma inhalers are more expensive. There is a Ventolin HFA inhaler with only 60 actuations (compared with 200 in most other inhalers) that is less expensive.



Augmentin (amoxicillin/clavulanic acid) combines amoxicillin with the β-lactamase inhibitor potassium clavulanate to help it overcome resistant bacteria. It is commonly used to treat ear infections, sinus infections, pneumonia, infected bites, and oral infections.

High-dose Augmentin (Augmentin ES) is also available to help treat resistant Streptococcus pneumononiae infections.



Omnicef (cefdinir) is a broad spectrum third-generation cephalosporin that is commonly used to treat sinus infections, ear infections, and pneumonia. Cefdinir is not usually considered to be a first-line treatment. In general, cefdinir is a little more expensive than some other antibiotics.



A first-generation cephalosporin, Keflex (cephalexin) is an antibiotic used to treat a range of bacterial infections, including strep throat, pneumonia, skin infections (cellulitis and impetigo), and bone and joint infections. It is available as an inexpensive generic.



Fluticasone is a steroid that is the main ingredient in many different medications, including Flonase nasal spray (generic), Flovent MDI, Cutivate cream and ointment (generic), and Veramyst nasal spray.

Depending on the formulation, it can be used to treat kids with conditions like eczema, allergies, and asthma. Generic fluticasone propionate nasal spray is now available over-the-counter and is one of the less expensive prescription nasal allergy medications.


Prednisolone Sodium Phosphate

Available in both a 25 milligram/5 milliliter and 15 milligram/5 milliliter syrup, prednisolone is a liquid steroid that is commonly used to treat asthma flare-ups, poison ivy reactions, croup, and other corticosteroid-responsive disorders.



Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat fever, pain, and inflammation in children. Although available over-the-counter (Motrin and Advil), there are also prescription-strength formulations of ibuprofen.


Singulair (Montelukast Sodium)

Singulair (montelukast sodium) is a leukotriene receptor antagonist and is approved to prevent and treat asthma, prevent exercise-induced asthma, and relieve symptoms of seasonal allergic rhinitis and perennial allergic rhinitis. It is available as a generic.



Bactrim or Septra (trimethoprim/sulfamethoxazole) is an older antibiotic that is most commonly used to treat urinary tract infections, except when resistance might be a problem.

It is also used to treat community-acquired methicillin-resistant staph aureus infections (MRSA), though clindamycin may be a more effective option for children.


Tylenol #3

Tylenol #3 (codeine phosphate/acetaminophen) a narcotic pain reliever with Tylenol (acetaminophen). The FDA warns that codeine should only be used when the benefits will outweigh the risks, which can include unusual sleepiness, confusion, shallow breathing, and other signs of morphine overdose.



Under the brand names of Vicodin, Lortab, and Norco, hydrocodone bitartrate/acetaminophen is a narcotic pain reliever with Tylenol (acetaminophen). It is more potent than codeine.



Bactroban (mupirocin) is a topical antibiotic that is often prescribed to treat bacterial skin infections, such as impetigo. Although both mupirocin cream and ointment are both available as generics, mupirocin ointment is considerably less expensive than the cream.



Most parents are familiar with Nystatin, an antifungal medication that is used to treat yeast infections, including thrush and candidal diaper rashes.



Methylphenidate is the generic name for a class of stimulants that are used to treat children with attention deficit hyperactivity disorder (ADHD), and which include Ritalin, Concerta, Daytrana, Methylin, and Metadate. Prices for methylphenidate products can vary.


Cough and Cold Combination

Dextromethorphan/phenylephrine/chlorpheniramine is a combination cough and cold medication, with a cough suppressant, decongestant, and an antihistamine.

While this seems like a popular combination cold medicine, it is important to remember that experts warn against using these types of cough and cold medicines in children under age 4 to 6 years.

Many also warn against using such combination medicines in general, instead recommending that you use cold medicines that target your child's symptoms in age-appropriate formulations. For example, don't use a combination cough and cold syrup if your child just needs a decongestant.



Mometasone is the active ingredient in Nasonex nasal spray, Elocon cream and ointment (generic), and the Asmanex Twisthaler. It is a corticosteroid used for allergy symptoms.



Another steroid, triamcinolone is the active ingredient in Nasacort AQ nasal spray and triamcinolone acetonide cream and ointment. Triamcinolone acetonide cream (TAC) is one of the least-expensive medications to treat eczema flares and other skin rashes.  Nasacort nasal spray is available as a generic and is now over-the-counter.



Prednisone is used to treat a number of corticosteroid-responsive disorders in children. It is commonly used in small dosages for short periods of time to treat asthma flares, poison ivy reactions, and croup.


Sodium Fluoride

For children who don't have access to fluoridated tap water, fluoride supplements can be an important way to keep their teeth healthy and prevent dental caries.


Multivitamins With Fluoride

In addition to fluoride supplements, when necessary, children can take a multivitamin with fluoride. In addition to fluoride, these usually include vitamin A, D, and C, and sometimes iron.



Adderall and Adderall XR are the brand names for this class of stimulants that are used to treat ADHD. Generic versions of intermediate release Adderall and extended-release Adderall XR are available.



Hydrocortisone is a low-potency topical steroid that is available as an ointment, cream, lotion, gel, and in other forms.



Budesonide is a steroid that is available as Pulmicort Respules (generic), Pulmicort Flexhaler, and Rhinocort nasal spray. Rhinocort nasal spray is available over-the-counter.



Ciprodex is the brand name for this combination of an antibiotic with a steroid that is often used to treat swimmer's ear and middle ear infections in kids with a perforated ​eardrum or ear tubes. There is no generic version of Ciprodex, but the manufacturer does offer a Ciprodex instant rebate.



Available as suppositories, tablets, and as a syrup, Phenergan (promethazine) can be used to prevent and control nausea and vomiting.

Warnings that Phenergan "may cause breathing to slow or stop, and may cause death in children," should be limiting its use now, especially as more pediatricians prescribe Zofran instead.



Prednisolone is a liquid steroid that is commonly used to treat asthma flare-ups, poison ivy reactions, croup, and other corticosteroid-responsive disorders.



Also simply called A/B otic drops, these analgesic ear drops can help relieve the pain and discomfort that can accompany an ear infection.

Not FDA-Approved

Unfortunately, most A/B otic drops were not FDA approved and the FDA announced enforcement actions against manufacturers in 2015.

According to the FDA, "The unapproved prescription ear drops contain active ingredients such as benzocaine and hydrocortisone​ and have not been evaluated by the FDA for safety, effectiveness, and quality. The labels on these products do not disclose that they lack FDA approval, and health care professionals may not be aware of their unapproved status."



Vyvanse (lisdexamfetamine) is the brand name of this class of stimulant that is used to treat ADHD. It is not available as a generic. You can get a Vyvanse coupon.

Frequently Asked Questions

  • How are standard dosages calculated for children's medication?

    The dosage of most pediatric medications is based on body weight. However, some experts argue other factors should be considered, including how a given medication works in the body and certain developmental factors. Some medications should be given to children in adult doses, such as vaccines and antidotes.

  • Can I put my child's medicine in a drink so they'll take it?

    You can, but don't mix it with so much fluid your child won't be able to finish the whole thing. Hiding it in food may be safer: Put the medicine on a spoon and then cover it with pudding or something else your child likes. Also, don't crush pills or open capsules unless the directions or your doctor say it's ok.

  • What should I do if my child spits out their medicine or throws it up?

    Call your child's doctor to find out if a repeat dose will be safe. Some drugs may cause side effects if even a little extra gets into a child's system.

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10 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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