Holistic Health Herbal Medicine The Health Benefits of Comfrey Cream By Cathy Wong facebook twitter Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Learn about our editorial process Cathy Wong Medically reviewed by Medically reviewed by Meredith Bull, ND on July 16, 2020 facebook linkedin Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles, California. Learn about our Medical Review Board Meredith Bull, ND on July 16, 2020 Print Verywell / Anastasia Tretiak Comfrey cream is a natural substance made from Symphytum officinale, an herb in the borage family. Also known as comfrey ointment, salve, or gel, it's said to reduce inflammation and alleviate pain when applied to the skin. Proponents claim that comfrey cream can treat a variety of health conditions and injuries. Comfrey cream contains several substances thought to possess beneficial properties, including anti-inflammatory compounds and allantoin, a substance thought to speed up wound healing by stimulating the growth of new cells. Uses Comfrey cream is typically used as a topical herbal remedy for painful muscle and joint conditions, such as low back pain, osteoarthritis, and sprains. It's also used in alternative medicine for the following problems: Bruises Fractures Gout Rheumatoid arthritis Sprains and strains Wounds Health Benefits Here's a look at some key findings on the potential health benefits of comfrey cream: Back Pain Comfrey cream could help ease back pain, suggests a 2010 study from the British Journal of Sports Medicine. The study included 120 patients with acute upper or lower back pain, each of whom was treated with comfrey ointment or a placebo for five days. Study results revealed that pain intensity decreased an average of 95.2 percent in the group given comfrey ointment (compared to 37.8 percent in the placebo group). Osteoarthritis Comfrey cream may help treat osteoarthritis of the knee, according to a Cochrane review of topical herbal therapies. This review included only one study of 220 people with osteoarthritis of the knee were assigned to three weeks of treatment with either comfrey ointment or a placebo. By the study's end, those who used the comfrey ointment had experienced a significantly greater improvement in pain, mobility, and quality of life (compared to members of the placebo group). Additionally, a 2011 study published in the Journal of Chiropractic Medicine found that comfrey ointment was superior to a placebo in relieving pain and stiffness and enhancing physical functioning. The study involved 43 patients with knee osteoarthritis and a six-week treatment period. However, a later study published in Osteoarthritis Cartilage in 2012 found some evidence that a topical comfrey cream containing comfrey extract reduced pain, but had no effect on markers of inflammation or cartilage breakdown over 12 weeks of treatment. Ankle Sprains Several studies show that comfrey cream may be helpful in the treatment of ankle sprains. Possible Side Effects Comfrey contains pyrrolizidine alkaloids, substances that can cause liver damage, cancer, and even death, so it should be never be taken by mouth. The Food and Drug Administration (FDA) has banned oral comfrey products. Since these toxic substances can be absorbed through the skin, there's concern about the safety of comfrey cream applied to the skin. It's typically only used in small amounts for a very short period of time. Experts suggest not using comfrey cream for longer than 10 days in a row and no longer than four to six weeks in a year as a general guideline, but it also depends on factors like skin thickness. If you're considering using the cream, consult your healthcare provider first to weigh the pros and cons and to use it only under his or her supervision. Never apply comfrey cream to broken skin or open wounds. Don't take it If you have liver disease, cancer, or are taking any medication that affects the liver. Children, elderly people, and pregnant or nursing women shouldn't use comfrey in any form. Verywell / Anastasia Tretiak Dosage and Preparation There is no daily recommended allowance for comfrey, which is sold in creams, ointments, gels, and salves. The following applications have been used in research: Back pain: An ointment containing 35 percent comfrey root extract, with or without 1.2 percent methyl nicotinate, applied three times a day for five days. Osteoarthritis: A specific ointment containing 35 percent comfrey root extract, with or without tannic acid, aloe vera gel, eucalyptus oil, and frankincense oil, applied to the knee three times a day for three to six weeks. For sprains: An ointment containing 35 percent comfrey extract applied to ankle sprains four times daily for eight days. What to Look For For topical comfrey cream, look for products labeled as free of pyrrolizidine alkaloids. When selecting a brand of supplements, look for products that have been certified by Consumer Labs, The U.S. Pharmacopeial Convention, or NSF International. Other Questions My doctor said I shouldn't use comfrey cream. What other alternatives are there for my back pain? The number one cause of disability worldwide, back pain is often treated with medication such as over-the-counter pain relievers. Other alternative therapies may help to ease the pain. Undergoing massage or taking up yoga may help alleviate pain and help people with back or joint problems function more easily. There's also some evidence that topical capsaicin cream may help to temporarily relieve pain. A Word From Verywell While studies suggest that comfrey cream may offer some pain-relieving benefits, large-scale clinical trials are needed to confirm these effects. Given the safety concerns, it should only be used under the supervision of your healthcare provider. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Salehi B, Sharopov F, Boyunegmez Tumer T, et al. Symphytum species: A comprehensive review on chemical composition, food applications and phytopharmacology. Molecules. 2019;24(12):2272. doi:10.3390/molecules24122272 Staiger, C. Comfrey root: from tradition to modern clinical trials. Wien Med Wochenschr. 2013;163:58–64 (2013) doi:10.1007/s10354-012-0162-4 Giannetti BM, Staiger C, Bulitta M, Predel HG. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo-controlled, multicentre trial. Br J Sports Med. 2010;44(9):637-41. doi:10.1136/bjsm.2009.058677 Cameron M, Chrubasik S. Topical herbal therapies for treating osteoarthritis. Cochrane Database Syst Rev. 2013;5(5):CD010538. doi:10.1002/14651858.CD010538 Smith DB, Jacobson BH. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. J Chiropr Med. 2011;10(3):147-56. doi:10.1016/j.jcm.2011.01.003 Laslett LL, Quinn SJ, Darian-Smith E, et al. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial. Osteoarthritis Cartilage. 2012;20(11):1209-16. doi:10.1016/j.joca.2012.07.019 Staiger C. Comfrey: A clinical overview. Phytother Res. 2012;26(10):1441–1448. doi:10.1002/ptr.4612 Gagnier JJ, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB. Herbal medicine for low back pain: A Cochrane review. Spine (Phila Pa 1976). 2016 Jan;41(2):116-33. doi:10.1097/01.brs.0000249525.70011.fe