The Uses and Benefits of Diosmin

Updated January 28, 2018
Oranges
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Although oranges, lemons, and other citrus fruit are known to be an excellent source of vitamin C, these fruit also contain diosmin, a little-known flavonoid compound found to possess antioxidant and anti-inflammatory properties. 

Diosmin is often referred to as a phlebotonic, a class of therapeutic agents used to improve the health of veins. It's also said to enhance the health of other types of blood vessels.

First used therapeutically in the 1960s, diosmin is widely available in dietary supplement form. In many cases, diosmin is taken in combination with hesperidin, another citrus fruit flavonoid. A supplement known as "micronized purified flavonoid fraction", or MPFF, is a combination of diosmin with hesperidin, typically in a 9:1 ratio. Diosmin can also be produced by extracting hesperidin from citrus rinds and modifying its components.

Uses for Diosmin

Diosmin is sometimes used as a remedy for the following health concerns:

In addition, diosmin is said to stimulate circulation, protect liver health, and reduce post-surgery swelling.

The Benefits of Diosmin

A number of studies suggest that diosmin may help with certain health conditions. Here's a look at some key findings on diosmin and its potential health benefits:

Chronic Venous Disease

Chronic venous disease refers to conditions that affect the veins of the legs. For instance, chronic venous insuffiency is a condition in which the veins do not effectively return blood from the legs to the heart, and is associated with varicose veins, ankle swelling, and nighttime leg cramping.

Diosmin and hesperidin may help to treat chronic venous disease, according to a study published in the journal Phlebology. The study included 136 people with chronic venous disease. After treatment with micronized diosmin and hesperidin (or other treatments or a placebo), reductions in fluid volume in the leg were more frequent in those taking diosmin and hesperidin.

Hemorrhoids

Several studies indicate that diosmin and other flavonoids may be beneficial in the treatment of hemorrhoids. For instance, a study published in Techniques in Coloproctology evaluated the effectiveness of diosmin, hesperidin, and troxerutin in people with acute hemorrhoids. After 12 days of treatment, pain, bleeding, and the proportion of people who reported persisting swelling and thrombosis decreased significantly in those taking the flavonoid mixture.

Side Effects and Safety

Diosmin may trigger a number of side effects including diarrhea, headache, and stomach pain. In one case report, diosmin was associated with elevated creatine phosphokinase levels and serum lactic dehydrogenase.

Diosmin may interact with medications, such as the antihistamine fexofenadine, the anti-epileptic drug carbamazepine, and anticoagulant medication (sometimes known as "blood thinners").

It should also be noted that self-treating any condition with diosmin and avoiding or delaying standard care may have serious consequences.

Where To Find It

Diosmin supplements are sold in many natural-foods stores and drugstores. You can also purchase diosmin online.

The Takeaway

Due to the limited research, it's too soon to recommend diosmin supplements for any condition. If you're still considering using diosmin, make sure to consult your healthcare provider first.

Sources:

Belczak SQ, Sincos IR, Campos W, et al. Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial. Phlebology. 2014 Aug;29(7):454-60.

Giannini I, Amato A, Basso L, et al. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloproctol. 2015 Jun;19(6):339-45.

Disclaimer: The information contained on this site is intended for educational purposes only and is not a substitute for advice, diagnosis or treatment by a licensed physician. It is not meant to cover all possible precautions, drug interactions, circumstances or adverse effects. You should seek prompt medical care for any health issues and consult your doctor before using alternative medicine or making a change to your regimen.